Comparative pharmacokinetics of coumarin anticoagulants L: Physiologic modeling of S-warfarin in rats and pharmacologic target-mediated warfarin disposition in man

2003 ◽  
Vol 92 (5) ◽  
pp. 985-994 ◽  
Author(s):  
Gerhard Levy ◽  
Donald E. Mager ◽  
Wing K. Cheung ◽  
William J. Jusko
Keyword(s):  
Physiologic Modeling

scholarly journals Tracer kinetics and physiologic modeling

1986 ◽  
Vol 7 (9-12) ◽  
pp. 1665-1666
Author(s):  
Kamlesh M. Thakker
Keyword(s):  
Tracer Kinetics ◽  
Physiologic Modeling

scholarly journals Morphometric and Physiologic Modeling Study for Endovascular Occlusion in Pediatric Trauma Patients

ASAIO Journal ◽  
2020 ◽  
Vol 66 (1) ◽  
pp. 97-104 ◽  
Author(s):  
Louis Carrillo ◽  
Max Skibber ◽  
Akshita Kumar ◽  
Mitchell George ◽  
Shahroz Aziz ◽  
...  
Keyword(s):  
Pediatric Trauma ◽  
Trauma Patients ◽  
Endovascular Occlusion ◽  
Physiologic Modeling ◽  
Modeling Study

scholarly journals Comparison of Cerebral Vascular Reactivity Measures Obtained Using Breath-Holding and CO2 Inhalation

2013 ◽  
Vol 33 (7) ◽  
pp. 1066-1074 ◽  
Author(s):  
Felipe B Tancredi ◽  
Richard D Hoge
Keyword(s):  
Arterial Spin Labeling ◽  
Vascular Reactivity ◽  
Automated System ◽  
Breath Holding ◽  
Breath Hold ◽  
Cerebral Vasculature ◽  
Fixed Concentration ◽  
Physiologic Modeling ◽  
End Tidal ◽  
Cerebral Vascular

Stimulation of cerebral vasculature using hypercapnia has been widely used to study cerebral vascular reactivity (CVR), which can be expressed as the quantitative change in cerebral blood flow (CBF) per mm Hg change in end-tidal partial pressure of CO2 (PETCO2). We investigate whether different respiratory manipulations, with arterial spin labeling used to measure CBF, lead to consistent measures of CVR. The approaches included: (1) an automated system delivering variable concentrations of inspired CO2 for prospective targeting of PETCO2, (2) administration of a fixed concentration of CO2 leading to subject-dependent changes in PETCO2, (3) a breath-hold (BH) paradigm with physiologic modeling of CO2 accumulation, and (4) a maneuver combining breath-hold and hyperventilation. When CVR was expressed as the percent change in CBF per mm Hg change in PETCO2, methods 1 to 3 gave consistent results. The CVR values using method 4 were significantly lower. When CVR was expressed in terms of the absolute change in CBF (mL/100g per minute per mm Hg), greater discrepancies became apparent: methods 2 and 3 gave lower absolute CVR values compared with method 1, and the value obtained with method 4 was dramatically lower. Our findings indicate that care must be taken to ensure that CVR is measured over the linear range of the CBF-CO2 dose-response curve, avoiding hypocapnic conditions.

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