Effect of Interferons on P‐Glycoprotein‐Mediated Rhodamine‐123 Efflux in Cultured Rat Hepatocytes

2002 ◽  
Vol 91 (10) ◽  
pp. 2110-2115 ◽  
Author(s):  
Yukiko Akazawa ◽  
Hiroko Kawaguchi ◽  
Maki Funahashi ◽  
Yoshihiko Watanabe ◽  
Kiyoshi Yamaoka ◽  
...  
Keyword(s):  
Rat Hepatocytes ◽  
Rhodamine 123 ◽  
P Glycoprotein ◽  
Cultured Rat Hepatocytes

Use of rhodamine 123 to assess P-glycoprotein activity in cultured rat hepatocytes

1991 ◽  
Vol 27 ◽  
pp. S44
Author(s):  
A. Paolicchi ◽  
E. Santoni-Rugiu ◽  
R. Tongiani ◽  
F. Cervelli ◽  
E. Chieli
Keyword(s):  
Rat Hepatocytes ◽  
Rhodamine 123 ◽  
P Glycoprotein ◽  
Cultured Rat Hepatocytes

Assessment of P-glycoprotein-dependent drug transport in isolated rat hepatocytes using rhodamine 123

1993 ◽  
Vol 9 (3) ◽  
pp. 235-241 ◽  
Author(s):  
E. Chieli ◽  
E. Santoni Rugiu ◽  
F. Cervelli ◽  
A. Paolicchi ◽  
R. Tongiani
Keyword(s):  
Drug Transport ◽  
Rat Hepatocytes ◽  
Rhodamine 123 ◽  
Isolated Rat Hepatocytes ◽  
P Glycoprotein ◽  
Isolated Rat

Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes

Life Sciences ◽  
1995 ◽  
Vol 57 (19) ◽  
pp. 1741-1751 ◽  
Author(s):  
Elisabetta Chieli ◽  
Nadia Romiti ◽  
Fabrizio Cervelli ◽  
Roberto Tongiani
Keyword(s):  
Rat Hepatocytes ◽  
P Glycoprotein ◽  
Cultured Rat Hepatocytes

In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves

2017 ◽  
Vol 32 (4) ◽  
Author(s):  
Carlos L. Pérez ◽  
Maria T. Donato ◽  
Ivones Hernández ◽  
Miriam T. Paz Lopes ◽  
Evangelina Marrero ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interaction ◽  
Cell Viability ◽  
Aqueous Extract ◽  
Rat Hepatocytes ◽  
Mtt Test ◽  
P Glycoprotein ◽  
Cultured Rat Hepatocytes ◽  
Cyp 1A2

AbstractBackground:The aqueous extract of theMethods:Considering the herb–drug interaction, the aim of this study was to evaluate the potential effects of theResults:The extract did not decrease the cell viability after being assayed by the MTT test at up to 1500 μg/mL for 72 h. The exposure of the cultured rat hepatocytes to the product (up to 250 μg/mL) for 48 h increased the activities of CYP-1A2, 2C9, and 2E1 by 1.46-, 1.60-, and 1.51-fold, respectively, compared with the controls. The activities of CYP-2B6, 2D6, and 3A4 were not significantly altered, whereas the activity of P-gp decreased by 2- and 4-fold. In addition, the extracts at 100 and 200 μg/mL significantly increased doxorubicin cytotoxicity in these cells 24 h after treatment.Conclusions:The findings indicate that the

Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes

FEBS Letters ◽  
1993 ◽  
Vol 327 (2) ◽  
pp. 189-193 ◽  
Author(s):  
Olivier Fardel ◽  
Valérie Lecureur ◽  
André Guillouzo
Keyword(s):  
Rat Hepatocytes ◽  
P Glycoprotein ◽  
Cultured Rat Hepatocytes

Nutrition and somatomedin. XXVI. Molecular regulation of IGF-I by insulin in cultured rat hepatocytes

Diabetes ◽  
1991 ◽  
Vol 40 (11) ◽  
pp. 1525-1530 ◽  
Author(s):  
L. S. Phillips ◽  
S. Goldstein ◽  
C. I. Pao
Keyword(s):  
Rat Hepatocytes ◽  
Molecular Regulation ◽  
Igf I ◽  
Cultured Rat Hepatocytes
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