scholarly journals Case series of immunosuppressant drug interactions with flucloxacillin in heart transplant recipients

2019 ◽  
Vol 49 (5) ◽  
pp. 466-470 ◽  
Author(s):  
Rochelle M Gellatly ◽  
Sookyung Yoo ◽  
Peter Bergin ◽  
Angeline Leet
Keyword(s):  
Drug Interactions ◽  
Heart Transplant ◽  
Case Series ◽  
Transplant Recipients ◽  
Immunosuppressant Drug ◽  
Heart Transplant Recipients

scholarly journals Outcomes of COVID-19 infection in heart transplant recipients

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
D Miklin ◽  
A Mantha ◽  
A Wolfson ◽  
A Vaidya ◽  
E Depasquale
Keyword(s):  
Heart Transplant ◽  
Academic Medical Center ◽  
Case Series ◽  
Transplant Recipients ◽  
Transplant Patients ◽  
Increased Risk ◽  
Gi Symptoms ◽  
History Of ◽  
The Mean ◽  
Heart Transplant Recipients

Abstract Background Heart transplant recipients may be at increased risk for infection and adverse outcomes from infection with COVID-19. Management of these patients is complex, with limited data and no standard of care. Purpose We sought to describe the incidence and outcomes of COVID-19 infection in patients with a history of heart transplant. Methods Retrospective review of 235 heart transplant patients at a large academic medical center identified 31 patients with laboratory confirmed COVID-19 infection. Laboratory and clinical data were collected from our institution as well as other local hospitals patients had been treated at. Outcomes were followed from March 15, 2020 to March 15, 2021. All data was deidentified. Results In a cohort of 235 heart transplant patients, 31 patients were identified after testing positive for COVID-19 infection. The mean and median age of patients was 51.9 and 56.0 years respectively. 71% of patients were male and 29% of patients were female. The mean and median time from transplant to diagnosis was 6.54 and 6.50 years. Average ejection fraction prior to infection was 60.4%. Seventeen patients (55%) had atherosclerosis, ten patients (32%) had diabetes, fifteen patients (48%) had hypertension, and twelve patients (39%) had a history of smoking. 84% of patients were on three types of immunosuppression and 16% were on two. Eight patients (26%) were asymptomatic, six patients (19%) had acute hypoxic respiratory failure, and two patients (7%) had GI symptoms. Two patients had evidence of graft injury with mean AlloSure (donor derived cell free DNA) levels of 0.61%. Immunosuppressive regimens were decreased in 32% of patients and COVID-19 directed therapies were given in 32% of patients. The most common treatments were remdesevir (5 patients), steroids (3 patients), and bamlanivimab (2 patients). Thirteen patients (42%) were hospitalized and two patients (7%) died. Conclusions In a single center case series 31 patients were identified with COVID-19 infection. Nearly half of the patients required hospitalization, with one third of patients decreasing their immunosuppressive regimen and 7% mortality. Further investigation is needed to determine long term outcomes and optimal therapeutic regimen for COVID-19 in this unique population. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Coronavirus Disease-2019 in Heart Transplant Recipients in Southeastern Michigan: A Case Series

2020 ◽  
Vol 26 (6) ◽  
pp. 457-461 ◽  
Author(s):  
Scott W. Ketcham ◽  
Sarah K. Adie ◽  
Ashley Malliett ◽  
Ahmad A. Abdul-Aziz ◽  
Abbas Bitar ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Case Series ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

scholarly journals Varying presentations of COVID‐19 in young heart transplant recipients: A case series

2020 ◽  
Vol 24 (8) ◽  
Author(s):  
Hannah Lee ◽  
Benjamin S. Mantell ◽  
Marc E. Richmond ◽  
Sabrina P. Law ◽  
Warren A. Zuckerman ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Case Series ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

scholarly journals Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Vincent Tchana-Sato ◽  
Arnaud Ancion ◽  
Julien Tridetti ◽  
Natzi Sakalihasan ◽  
Marie Pierre Hayette ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Clinical Course ◽  
Case Reports ◽  
Organ Transplant ◽  
Case Series ◽  
Perioperative Period ◽  
Severe Form ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

Abstract Background There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. Case presentation This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplant recipients who tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. Conclusions These two cases illustrate the severity and poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory, and the issue of asymptomatic carriers needs to be addressed.

scholarly journals Clinical course and challenging management of early COVID-19 infection after heart transplantation: Case report of two patients

2020 ◽  
Author(s):  
Vincent Tchana-Sato ◽  
Arnaud Ancion ◽  
Julien Tridetti ◽  
Natzi Sakalihasan ◽  
Marie pierre Hayette ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Clinical Course ◽  
Asymptomatic Carrier ◽  
Case Reports ◽  
Organ Transplant ◽  
Case Series ◽  
Perioperative Period ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

Abstract Background: There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients and especially in heart transplant recipients with only few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. Case presentation: This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplants recipients who were tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease, and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. Conclusions: These two cases illustrate the severity and the poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory and the issue of asymptomatic carrier need to be addressed.

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