Conflicts of interest in research on antipsychotic treatment of pediatric bipolar disorder, temper dysregulation disorder, and attenuated psychotic symptoms syndrome: Exploring the unholy alliance between big pharma and psychiatry

2011 ◽  
Vol 1 (4) ◽  
pp. 32-49 ◽  
Author(s):  
Brent Dean Robbins ◽  
Meghan Higgins ◽  
Maureen Fisher ◽  
Katie Over
Keyword(s):  
Bipolar Disorder ◽  
Conflicts Of Interest ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
Antipsychotic Treatment ◽  
Interest In Research

Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness

2006 ◽  
Vol 96 (1-2) ◽  
pp. 127-131 ◽  
Author(s):  
Richard Rende ◽  
Boris Birmaher ◽  
David Axelson ◽  
Michael Strober ◽  
Mary Kay Gill ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Psychiatric Illness ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
History Of

scholarly journals Shared And Specific Patterns Of Structural And Functional Thalamo-Frontal Disturbances In Manic And Euthymic Pediatric Bipolar Disorder

2021 ◽  
Author(s):  
Yi-Bing Guo ◽  
Wei-Jia Gao ◽  
Zhi-Liang Long ◽  
Wei-Fang Cao ◽  
Dong Cui ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cortical Thickness ◽  
Vital Role ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
Detailed Knowledge ◽  
Precentral Gyrus ◽  
Treatment Target ◽  
Clinical Indices ◽  
Left Thalamus

Abstract Bipolar disorder (BD) is clinically defined by alternating depressive and manic episodes with a separated period of euthymia. Thalamo-frontal loop plays vital role in psychotic symptoms, altered motor control and executive difficulties in BD. It remains unclear that structural and functional alteration of thalamo-frontal loop among the different mood states in BD, especially in pediatric BD(PBD).Twenty manic PBD(mPBD), 20 euthymic PBD(ePBD) and 19 healthy controls were included in the study. By analyzing the T1 images and fMRI signals, thalamus volume and frontal grey matter cortical thickness were tested, and functional connectivity(FC) between bilateral thalamus and frontal cortex was calculated. Relationship between clinical indices and thalamo-frontal FC was also evaluated in mPBD and ePBD adolescents.Compared to HCs, the cortical thickness of left MFG, bilateral superior frontal gyrus(SFG) was significantly decreased in both mPBD and ePBD patients, and volume of left thalamus and cortical thickness of right middle frontal gyrus(MFG) significantly decreased in mPBD patients. It was shown that thalamo-frontal hyperconnectivity with MFG in mPBD compared to HCs and ePBD subjects, and thalamo-frontal hypoconnectivity with precentral gyrus/SFG in ePBD subjects compared with that of HCs. In ePBD patients, episode times positively correlated with FC values between thalamus and precentral gyrusThe findings of the present study demonstrate detailed knowledge regarding shared and specific structural and functional disruption in thalamo-frontal loop in mPBD and ePBD subjects. Thalamo-frontal abnormalities reported in adult BD subjects were also observed in adolescent BD patients, and thalamo-frontal dysfunction may be a crucial treatment target in BD.

scholarly journals Shared and specific patterns of structural and functional thalamo-frontal disturbances in manic and euthymic pediatric bipolar disorder

2021 ◽  
Vol 15 (5) ◽  
pp. 2671-2680
Author(s):  
Yi-Bing Guo ◽  
Wei-Jia Gao ◽  
Zhi-Liang Long ◽  
Wei-Fang Cao ◽  
Dong Cui ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cortical Thickness ◽  
Vital Role ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
Detailed Knowledge ◽  
Precentral Gyrus ◽  
Treatment Target ◽  
Clinical Indices ◽  
Left Thalamus

AbstractBipolar disorder (BD) is clinically defined by alternating depressive and manic episodes with a separated period of euthymia. Thalamo-frontal loop plays vital role in psychotic symptoms, altered motor control and executive difficulties in BD. It remains unclear that structural and functional alterations of thalamo-frontal loop among the different mood states in BD, especially in pediatric BD(PBD).Twenty manic PBD (mPBD), 20 euthymic PBD (ePBD) and 19 healthy controls (HCs) were included in the study. By analyzing the T1 images and fMRI signals, thalamus volume and frontal grey matter cortical thickness were tested, and functional connectivity (FC) between bilateral thalamus and frontal cortex was calculated. Relationship between clinical indices and thalamo-frontal FC was also evaluated in mPBD and ePBD adolescents.Compared to HCs, the cortical thickness of left middle frontal gyrus (MFG), bilateral superior frontal gyrus (SFG) was significantly decreased in both mPBD and ePBD patients, and volume of left thalamus and cortical thickness of right MFG significantly decreased in mPBD patients. Compared to that of the HCs and ePBD subjects, thalamo-frontal hyperconnectivity with MFG was found in mPBD, and compared with that of HCs, thalamo-frontal hypoconnectivity with precentral gyrus/SFG was found in ePBD. In ePBD patients, episode times positively correlated with FC values between thalamus and precentral gyrus.The findings of the present study demonstrate detailed knowledge regarding shared and specific structural and functional disruption in thalamo-frontal loop in mPBD and ePBD subjects. Thalamo-frontal abnormalities reported in adult BD subjects were also observed in adolescent BD patients, and thalamo-frontal dysfunction may be a crucial treatment target in BD.

scholarly journals Disrupted brain structural connectivity in Pediatric Bipolar Disorder with psychosis

2017 ◽  
Author(s):  
Henrique M. Fernandes ◽  
Joana Cabral ◽  
Tim J. Van Hartevelt ◽  
Louis-David Lord ◽  
Carsten Gleesborg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Network Topology ◽  
Orbitofrontal Cortex ◽  
Emotional Processing ◽  
Brain Connectivity ◽  
Structural Connectivity ◽  
Brain Regions ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
Integrative Processing

AbstractBipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks and limbic brain regions. Studies of patients with pediatric bipolar disorder (PBD) can help elucidate the developmental origins of altered structural connectivity underlying BD and provide novel insights into the aetiology of BD. Here we compare the network properties of whole-brain structural connectomes of PBD patients with psychosis and euthymic matched healthy controls. Our results show widespread changes in the structural connectivity of PBD patients in both cortical and subcortical networks, notably affecting the orbitofrontal cortex, frontal gyrus, amygdala, hippocampus and basal ganglia. Graph theoretical analysis revealed that PBD connectomes have fewer hubs, weaker rich club organization, different modular fingerprint and inter-modular communication, compared to healthy participants. The relationship between network features and neurocognitive and psychotic scores was also assessed. Patients’ IQ and psychotic symptoms significantly correlated with the local efficiency of the orbitofrontal cortex. Our findings reveal that PBD is associated with significant widespread changes in structural network topology, thus strengthening the hypothesis of a reduced capacity for integrative processing of information across brain regions. Localised network changes involve core regions for emotional processing and regulation, as well as memory and executive function, some of which correlate with neurocognitive faculties and symptoms. Together, our findings provide the first comprehensive characterisation of the alterations in local and global structural brain connectivity and network topology, which may contribute to the deficits in cognition and emotion processing and regulation found in PBD.

Conflicts of Interest in Research on Antipsychotic Treatment of Pediatric Psychological Disorders

2011 ◽  
Author(s):  
Brent D. Robbins ◽  
Sharna Olfman ◽  
Katie Over ◽  
Meghan Higgins ◽  
Maureen Fisher
Keyword(s):  
Conflicts Of Interest ◽  
Psychological Disorders ◽  
Antipsychotic Treatment ◽  
Interest In Research

Psychotic symptoms in pediatric bipolar disorder

2004 ◽  
Vol 80 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Mani N. Pavuluri ◽  
Ellen S. Herbener ◽  
John A. Sweeney
Keyword(s):  
Bipolar Disorder ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder

scholarly journals Bipolar Disorder and Multiple Sclerosis: A Case Series

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Youssef Sidhom ◽  
Mouna Ben Djebara ◽  
Yosr Hizem ◽  
Istabrak Abdelkefi ◽  
Imen Kacem ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Bipolar Disorder ◽  
Interferon Beta ◽  
Psychiatric Symptoms ◽  
Treatment Options ◽  
Case Series ◽  
Psychotic Symptoms ◽  
Antipsychotic Treatment ◽  
High Dose ◽  
Psychiatric Disturbance

Background.The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options.Observations.All patients fulfilled the McDonald criteria for MS. Two patients were followed up in psychiatry for manic or depressive symptoms before developing MS. A third patient was diagnosed with MS and developed deferred psychotic symptoms. Some clinical and radiological features are highlighted in our patients: one manic episode induced by high dose corticosteroids and one case of a new orbitofrontal MRI lesion concomitant with the emergence of psychiatric symptoms. All patients needed antipsychotic treatment with almost good tolerance for high dose corticosteroids and interferon beta treatment.Conclusions.MRI lesions suggest the possible implication of local MS-related brain damage in development of pure “psychiatric fits” in MS. Genetic susceptibility is another hypothesis for this association. We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits.

scholarly journals Disrupted brain structural connectivity in Pediatric Bipolar Disorder with psychosis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Henrique M. Fernandes ◽  
Joana Cabral ◽  
Tim J. van Hartevelt ◽  
Louis-David Lord ◽  
Carsten Gleesborg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Network Topology ◽  
Orbitofrontal Cortex ◽  
Emotional Processing ◽  
Brain Connectivity ◽  
Structural Connectivity ◽  
Brain Regions ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
Integrative Processing

Abstract Bipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks and limbic brain regions. Studies of patients with pediatric bipolar disorder (PBD) can help elucidate the developmental origins of altered structural connectivity underlying BD and provide novel insights into the aetiology of BD. Here we compare the network properties of whole-brain structural connectomes of euthymic PBD patients with psychosis, a variant of PBD, and matched healthy controls. Our results show widespread changes in the structural connectivity of PBD patients with psychosis in both cortical and subcortical networks, notably affecting the orbitofrontal cortex, frontal gyrus, amygdala, hippocampus and basal ganglia. Graph theoretical analysis revealed that PBD connectomes have fewer hubs, weaker rich club organization, different modular fingerprint and inter-modular communication, compared to healthy participants. The relationship between network features and neurocognitive and psychotic scores was also assessed, revealing trends of association between patients’ IQ and affective psychotic symptoms with the local efficiency of the orbitofrontal cortex. Our findings reveal that PBD with psychosis is associated with significant widespread changes in structural network topology, thus strengthening the hypothesis of a reduced capacity for integrative processing of information across brain regions. Localised network changes involve core regions for emotional processing and regulation, as well as memory and executive function, some of which show trends of association with neurocognitive faculties and symptoms. Together, our findings provide the first comprehensive characterisation of the alterations in local and global structural brain connectivity and network topology, which may contribute to the deficits in cognition and emotion processing and regulation found in PBD.

Sign in / Sign up

Export Citation Format

Share Document