scholarly journals Estimation of the diagnostic accuracy of clinical parameters for monitoring peri-implantitis progression: An experimental canine study

2018 ◽  
Vol 89 (12) ◽  
pp. 1442-1451 ◽  
Author(s):  
Alberto Monje ◽  
Angel Insua ◽  
Mia Rakic ◽  
Jose Nart ◽  
Jose Luis Moyano-Cuevas ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Clinical Parameters ◽  
Experimental Canine ◽  
Canine Study

Patellar Tendon Attachment and Healing to Porous Tantalum: An Experimental Canine Study

2006 ◽  
Vol 21 (2) ◽  
pp. 303 ◽  
Author(s):  
Ari Itala ◽  
John Reach ◽  
Franklin H. Sim ◽  
Kai-Nan An ◽  
David G. Lewallen
Keyword(s):  
Patellar Tendon ◽  
Porous Tantalum ◽  
Experimental Canine ◽  
Canine Study

scholarly journals Incremental benefits of echocardiographic indices over clinical parameters for screening cardiac amyloidosis in patients with left ventricular hypertrophy

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Saito ◽  
Y Nakao ◽  
R Higaki ◽  
Y Yokomoto ◽  
A Ogimoto ◽  
...  
Keyword(s):  
Ejection Fraction ◽  
Diagnostic Accuracy ◽  
Wall Thickness ◽  
Left Atrial ◽  
Cardiac Amyloidosis ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Volume Index ◽  
Clinical Parameters ◽  
Clinical Model

Abstract Background Cardiac amyloidosis (CA), characterized by amyloid protein deposition in the heart, is a treatable disease. Although left ventricular (LV) wall thickness is the most established imaging predictor for CA, several echocardiographic indices including deformation parameters also contribute to the screening of CA. However, it is unclear whether additive values of echocardiographic indices have greater benefit over the conventional clinical predictors for the screening of CA. Therefore, we sought to compare the incremental benefits of echocardiographic indices over the clinical parameters for the screening of CA and externally validate their incremental benefits. Methods We retrospectively studied 295 consecutive patients (median age, 67 years; male, 65%; mean LV wall thickness (MWT), 12 mm) with LV hypertrophy who underwent echocardiography as well as the detailed work-up for myocardium (Biopsy, technetium pyrophosphate scintigraphy (99mTc-PYP) or cardiac magnetic resonance imaging). CA was diagnosed through biopsy or 99mTc-PYP. The clinical model considers patients' age and the low-voltage in electrocardiography in reference to previous studies. Continuous echocardiographic variables were represented in binary through generally accepted external cutoff points. The incremental benefits of the echocardiography findings over the clinical model were assessed using with the help of both receiver-operated characteristic curve analysis and comparison of area under the curves. Furthermore, these incremental benefits were validated in the external validation sample (median age, 70 years; male, 69%; MWT, 12 mm). Results Among the enrolled patients, CA was observed in 18% of cases. Table presents the results of this study. Of the echocardiographic parameters, relative apical sparing pattern (RASP) was the greatest contributor for improvement of diagnostic accuracy of the clinical model. The next greatest contributor was LV wall thickness, followed by left atrial reservoir strain (LAS), E/e', left atrial volume index, ejection fraction strain ratio, and pericardial effusion, respectively. Similarly, RASP, LV wall thickness, global longitudinal strain, ejection fraction, LAS, and granular sparkling showed significant incremental benefit in the validation cohort. Only mean wall thickness, LV wall thickness, LAS, E/e' and RASP consistently improved the diagnostic accuracy of the clinical model. Conclusion During the screening process, adding LV wall thickness, LAS, and RASP to the clinical parameters may be useful for the accurate diagnosis of CA in patients with LV hypertrophy. Figure 1 Funding Acknowledgement Type of funding source: None

scholarly journals Left atrial appendage amputation using a modified appendage clip: an experimental canine study

2020 ◽  
Vol 133 (21) ◽  
pp. 2644-2646
Author(s):  
Shuo Zhang ◽  
Hong-Xin Li ◽  
Fang-Li Sun ◽  
Zhen-Wei Guo ◽  
Mei Zhu ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
Experimental Canine ◽  
Canine Study

scholarly journals Limited Predictive Value of Serum Inflammatory Markers for Diagnosing Fracture-Related Infections: results of a large retrospective multicenter cohort study

2018 ◽  
Vol 3 (3) ◽  
pp. 130-137 ◽  
Author(s):  
Paul Bosch ◽  
Janna van den ◽  
Joost D.J. Plate ◽  
Frank F.A. IJpma ◽  
R. Marijn Houwert ◽  
...  
Keyword(s):  
Cohort Study ◽  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Inflammatory Markers ◽  
Diagnostic Performance ◽  
Added Value ◽  
Clinical Parameters ◽  
Discriminative Performance ◽  
The Individual ◽  
Serum Inflammatory Markers

Abstract. Introduction: Diagnosing Fracture-Related Infections (FRI) based on clinical symptoms alone can be challenging and additional diagnostic tools such as serum inflammatory markers are often utilized. The aims of this study were 1) to determine the individual diagnostic performance of three commonly used serum inflammatory markers: C-Reactive Protein (CRP), Leukocyte Count (LC) and Erythrocyte Sedimentation Rate (ESR), and 2) to determine the diagnostic performance of a combination of these markers, and the additional value of including clinical parameters predictive of FRI.Methods: This cohort study included patients who presented with a suspected FRI at two participating level I academic trauma centers between February 1st 2009 and December 31st 2017. The parameters CRP, LC and ESR, determined at diagnostic work-up of the suspected FRI, were retrieved from hospital records. The gold standard for diagnosing or ruling out FRI was defined as: positive microbiology results of surgically obtained tissue samples, or absence of FRI at a clinical follow-up of at least six months. The diagnostic accuracy of the individual serum inflammatory markers was assessed. Analyses were done with both dichotomized values using hospital thresholds as well as with continuous values. Multivariable logistic regression analyses were performed to obtain the discriminative performance (Area Under the Receiver Operating Characteristic, AUROC) of (1) the combined inflammatory markers, and (2) the added value of these markers to clinical parameters.Results: A total of 168 patients met the inclusion criteria and were included for analysis. CRP had a 38% sensitivity, 34% specificity, 42% positive predictive value (PPV) and 78% negative predictive value (NPV). For LC this was 39%, 74%, 46% and 67% and for ESR 62%, 64%, 45% and 76% respectively. The diagnostic accuracy was 52%, 61% and 80% respectively. The AUROC was 0.64 for CRP, 0.60 for LC and 0.58 for ESR. The AUROC of the combined inflammatory markers was 0.63. Serum inflammatory markers combined with clinical parameters resulted in AUROC of 0.66 as opposed to 0.62 for clinical parameters alone.Conclusion: The added value of CRP, LC and ESR for diagnosing FRI is limited. Clinicians should be cautious when interpreting the results of these tests in patients with suspected FRI.

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