Cost‐effectiveness of ethanol lock prophylaxis to prevent central line‐associated bloodstream infections in children with intestinal failure in the United States

2021 ◽  
Author(s):  
Vikram Kalathur Raghu ◽  
Ethan A. Mezoff ◽  
Conrad R. Cole ◽  
Jeffrey A. Rudolph ◽  
Kenneth J. Smith
Keyword(s):  
United States ◽  
Cost Effectiveness ◽  
Intestinal Failure ◽  
Bloodstream Infections ◽  
The United States ◽  
Central Line ◽  
Ethanol Lock

Efficacy in the Reduction of Central Line-Associated Bloodstream Infection in a Patient With Intestinal Failure: An Ethanol Lock Pediatric Case Study

2014 ◽  
Vol 19 (4) ◽  
pp. 217-220 ◽  
Author(s):  
Stephanie Pitts ◽  
Dale Bergamo ◽  
Carlos Cartaya ◽  
Beth Gore
Keyword(s):  
Bloodstream Infection ◽  
Intestinal Failure ◽  
Bloodstream Infections ◽  
Central Line ◽  
Central Venous ◽  
Pediatric Case ◽  
Time Period ◽  
Lock Therapy ◽  
Ethanol Lock

Abstract Intestinal failure and the subsequent reliance on parentral nutrition through central venous catheters increases the likelihood of a central line-associated bloodstream infection. Antimicrobial lock solutions such as ethanol lock therapy are providing promising evidence of the ability to reduce central line-associated bloodstream infection. This case study reviews the use of ethanol lock therapy for a pediatric patient who experienced 0 central line-associated bloodstream infections during the 2-year time period covered by this report.

Preventing Peripheral Intravenous Line Infections: Recommendations for Healthcare Facilities

2009 ◽  
Vol 14 (4) ◽  
pp. 187-190 ◽  
Author(s):  
Nancy Moureau
Keyword(s):  
United States ◽  
Bloodstream Infections ◽  
Venous Catheter ◽  
The United States ◽  
Central Line ◽  
Intravenous Catheter ◽  
Central Lines ◽  
Healthcare Facilities ◽  
Peripheral Intravenous Catheter ◽  
Intravascular Devices

Intravascular catheters are indispensable tools in acute care, but with the benefits come the risk of local or systemic Healthcare Acquired Infections (HAIs). In fact, more than 250,000–500,000 intravascular-related bloodstream infections occur in the United States each year with resulting mortality rates of 12%–25%. (Maki, Kluger & Crnich, 2006; CDC, 2002). While bloodstream infections related to the use of peripheral lines may not occur as often as they do with central lines, they do occur. Although most studies focus on central catheter-related bloodstream infections due to their greater documented prevalence and severity, some studies have evaluated the prevalence of peripheral intravenous catheter-associated bloodstream infections. In 2006 Maki reviewed 200 studies that prospectively examined the risk of Bloodstream Infections (BSIs) associated with intravascular devices over a forty year period. The infection rate with peripheral intravenous catheters was 0.5 per 1000 catheter days. Though the frequency of peripheral intravenous catheter-associated infections is lower than with other intravascular devices, absolute numbers of patients affected can be significant with more than 330 million peripheral catheters sold each year in the United States (Millennium Research Group, 2006). Some doctors are stressing the need to use a peripheral line versus early placement of a central line with the rationale to reduce infection rates. Multiple national and international guidelines advocate a number of simple, yet highly effective procedures to reduce risk of central venous catheter infections. Some of these same guidelines should be applied as standards for peripheral catheters. By standardizing protocols across all types of catheter insertions, safety is ensured in reducing infections and ultimately improving patient care.

scholarly journals National Estimates of Central Line–Associated Bloodstream Infections in Critical Care Patients

2013 ◽  
Vol 34 (6) ◽  
pp. 547-554 ◽  
Author(s):  
Matthew E. Wise ◽  
R. Douglas Scott ◽  
James M. Baggs ◽  
Jonathan R. Edwards ◽  
Katherine D. Ellingson ◽  
...  
Keyword(s):  
United States ◽  
Critical Care ◽  
Bloodstream Infections ◽  
The United States ◽  
Central Line ◽  
Teaching Hospitals ◽  
Annual Number ◽  
Network Systems ◽  
Substantial Progress ◽  
Critical Care Patients

Objective.Recent studies have demonstrated that central line-associated bloodstream infections (CLABSIs) are preventable through implementation of evidence-based prevention practices. Hospitals have reported CLABSI data to the Centers for Disease Control and Prevention (CDC) since the 1970s, providing an opportunity to characterize the national impact of CLABSIs over time. Our objective was to describe changes in the annual number of CLABSIs in critical care patients in the United States.Design.Monte Carlo simulation.Setting.US acute care hospitals.Patients.Nonneonatal critical care patients.Methods.We obtained administrative data on patient-days for nearly all US hospitals and applied CLABSI rates from the National Nosocomial Infections Surveillance and the National Healthcare Safety Network systems to estimate the annual number of CLABSIs in critical care patients nationally during the period 1990–2010 and the number of CLABSIs prevented since 1990.Results.We estimated that there were between 462,000 and 636,000 CLABSIs in nonneonatal critical care patients in the United States during 1990–2010. CLABSI rate reductions led to between 104,000 and 198,000 fewer CLABSIs than would have occurred if rates had remained unchanged since 1990. There were 15,000 hospital-onset CLABSIs in nonneonatal critical care patients in 2010; 70% occurred in medium and large teaching hospitals.Conclusions.Substantial progress has been made in reducing the occurrence of CLABSIs in US critical care patients over the past 2 decades. The concentration of critical care CLABSIs in medium and large teaching hospitals suggests that a targeted approach may be warranted to continue achieving reductions in critical care CLABSIs nationally.

Cost-Effectiveness of Inhaled Nitric Oxide in the Treatment of Neonatal Respiratory Failure in the United States

PEDIATRICS ◽  
2003 ◽  
Vol 112 (6) ◽  
pp. 1351-1360 ◽  
Author(s):  
D. C. Angus ◽  
G. Clermont ◽  
R. S. Watson ◽  
W. T. Linde-Zwirble ◽  
R. H. Clark ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
United States ◽  
Cost Effectiveness ◽  
Respiratory Failure ◽  
The United States ◽  
Inhaled Nitric Oxide

scholarly journals Cost-effectiveness for KTE-X19 CAR T therapy for adult patients with relapsed/refractory mantle cell lymphoma in the United States

2021 ◽  
Vol 24 (1) ◽  
pp. 421-431
Author(s):  
Claire L. Simons ◽  
Daniel Malone ◽  
Michael Wang ◽  
Gregory A. Maglinte ◽  
Tim Inocencio ◽  
...  
Keyword(s):  
United States ◽  
Cost Effectiveness ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
The United States ◽  
Adult Patients ◽  
Car T ◽  
Mantle Cell
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