MuRF1 Deficiency Prevents Age‐Related Fat Weight Gain, Possibly Through Accumulation of PDK4 in Skeletal Muscle Mitochondria in Older Mice

2021 ◽  
Author(s):  
Kosuke Sugiura ◽  
Katsuya Hirasaka ◽  
Tasuku Maeda ◽  
Takayuki Uchida ◽  
Koji Kishimoto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Weight Gain ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria ◽  
Age Related

scholarly journals Age-related changes in skeletal muscle mitochondria: the role of exercise

2016 ◽  
Vol 5 (3) ◽  
pp. 182-186 ◽  
Author(s):  
Dae Yun Seo ◽  
Sung Ryul Lee ◽  
Nari Kim ◽  
Kyung Soo Ko ◽  
Byoung Doo Rhee ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria ◽  
Age Related ◽  
Age Related Changes

scholarly journals Skeletal Muscle Mitochondria and Aging: A Review

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
Courtney M. Peterson ◽  
Darcy L. Johannsen ◽  
Eric Ravussin
Keyword(s):  
Skeletal Muscle ◽  
Morphological Changes ◽  
Mitochondrial Dynamics ◽  
Mitochondrial Enzymes ◽  
Primary Role ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria ◽  
Age Related ◽  
Induced Apoptosis ◽  
Effects Of Aging

Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines in skeletal muscle mitochondria are thought to play a primary role in this process. Mitochondria are the major producers of reactive oxygen species, which damage DNA, proteins, and lipids if not rapidly quenched. Animal and human studies typically show that skeletal muscle mitochondria are altered with aging, including increased mutations in mitochondrial DNA, decreased activity of some mitochondrial enzymes, altered respiration with reduced maximal capacity at least in sedentary individuals, and reduced total mitochondrial content with increased morphological changes. However, there has been much controversy over measurements of mitochondrial energy production, which may largely be explained by differences in approach and by whether physical activity is controlled for. These changes may in turn alter mitochondrial dynamics, such as fusion and fission rates, and mitochondrially induced apoptosis, which may also lead to net muscle fiber loss and age-related sarcopenia. Fortunately, strategies such as exercise and caloric restriction that reduce oxidative damage also improve mitochondrial function. While these strategies may not completely prevent the primary effects of aging, they may help to attenuate the rate of decline.

Determinants of maximal whole-body fat oxidation in elite cross-country skiers: Role of skeletal muscle mitochondria

2018 ◽  
Vol 28 (12) ◽  
pp. 2494-2504 ◽  
Author(s):  
Sune Dandanell ◽  
Anne-Kristine Meinild-Lundby ◽  
Andreas B. Andersen ◽  
Paul F. Lang ◽  
Laura Oberholzer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Fat ◽  
Fat Oxidation ◽  
Whole Body ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria ◽  
Cross Country

Proton leak induced by reactive oxygen species produced during in vitro anoxia/reoxygenation in rat skeletal muscle mitochondria

2006 ◽  
Vol 38 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Rachel Navet ◽  
Ange Mouithys-Mickalad ◽  
Pierre Douette ◽  
Claudine M. Sluse-Goffart ◽  
Wieslawa Jarmuszkiewicz ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Reactive Oxygen ◽  
Proton Leak ◽  
Oxygen Species ◽  
Rat Skeletal Muscle ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria
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