MMPs in tissues retrieved during surgery from patients with TMJ disorders relate to pain more than to radiological damage score

2021 ◽  
Author(s):  
Meagan E. Ita ◽  
Prabesh Ghimire ◽  
Eric J. Granquist ◽  
Beth A. Winkelstein
Keyword(s):  
Damage Score ◽  
Radiological Damage

Resistance of cherry varieties to spring return frozes in the conditions of Astrakhan region

2020 ◽  
Author(s):  
A.A. Dronic A.A. ◽  
Keyword(s):  
Weather Conditions ◽  
Damage Score ◽  
The Stability ◽  
Almost All ◽  
Total Damage ◽  
Continental Climate ◽  
Unfavorable Weather

The article presents an assessment of the stability of introduced cherry varieties to spring return frosts in 2020 in the conditions of the sharply continental climate of the Astrakhan region. As a result of unfavorable weather conditions, the total damage score of all varieties was 2-5 points. Almost all the studied varieties showed an insufficient level of resistance to recurrent frosts.

Clinical and radiological outcomes of 5-year drug-free remission-steered treatment in patients with early arthritis: IMPROVED study

2017 ◽  
Vol 77 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Gülşah Akdemir ◽  
Lotte Heimans ◽  
Sytske Anne Bergstra ◽  
Robbert J Goekoop ◽  
Maikel van Oosterhout ◽  
...  
Keyword(s):  
Functional Ability ◽  
Health Assessment ◽  
Joint Damage ◽  
Early Arthritis ◽  
Remission Induction ◽  
Treatment Groups ◽  
Damage Progression ◽  
Normal Functional ◽  
Radiological Damage ◽  
Drug Free

ObjectivesTo determine the 5-year outcomes of early remission induction therapy followed by targeted treatment aimed at drug-free remission (DFR) in patients with early arthritis.MethodsIn 12 hospitals, 610 patients with early (<2 years) rheumatoid arthritis (RA) or undifferentiated arthritis (UA) started on methotrexate (MTX) 25 mg/week and prednisone (60 mg/day tapered to 7.5 mg/day). Patients not in early remission (Disease Activity Score <1.6 after 4 months) were randomised (single blind) to arm 1, adding hydroxychloroquine 400 mg/day and sulfasalazine 2000 mg/day, or arm 2, switching to MTX plus adalimumab 40 mg/2 weeks. Treatment adjustments over time aimed at DFR. Outcomes were remission percentages, functional ability, toxicity and radiological damage progression after 5 years.ResultsAfter 4 months, 387 patients were in early remission, 83 were randomised to arm 1 and 78 to arm 2. After 5 years, 295/610 (48%) patients were in remission, 26% in sustained DFR (SDFR) (≥1 year) (220/387 (57%) remission and 135/387 (35%) SDFR in the early remission group, 50% remission, 11% SDFR in the randomisation arms without differences between the arms). More patients with UA (37% vs 23% RA, p=0.001) and more anticitrullinated protein antibody (ACPA)-negative patients (37% vs 18% ACPA-positive, p<0.001) achieved SDFR.Overall, mean Health Assessment Questionnaire was 0.6 (0.5), and median (IQR) damage progression was 0.5 (0–2.7) Sharp/van der Heijde points, with only five patients showing progression >25 points in 5 years.ConclusionsFive years of DFR-steered treatment in patients with early RA resulted in almost normal functional ability without clinically relevant joint damage across treatment groups. Patients who achieved early remission had the best clinical outcomes. There were no differences between the randomisation arms. SDFR is a realistic treatment goal.

scholarly journals OP0339 Development of a predictive model of radiological damage in patients with rheumatoid arthritis based on artificial intelligence

2018 ◽  
Author(s):  
J.M. Lezcano ◽  
J. Ivorra-Cortes ◽  
R. López Mejías ◽  
J. Martín ◽  
B. Fernandez-Gutiérrez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Artificial Intelligence ◽  
Predictive Model ◽  
Radiological Damage

scholarly journals A global genome damage score predictive of lung cancer patients outcome

Oncogene ◽  
2006 ◽  
Vol 25 (32) ◽  
pp. 4491-4494
Author(s):  
Z Zheng ◽  
A Cantor ◽  
G Bepler
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Damage Score ◽  
Lung Cancer Patients ◽  
Genome Damage

Quantification of antibiosis levels in nine different rice genotypes against Nilaparvata lugens (Homoptera: Delphacidae)

2018 ◽  
Vol 38 (04) ◽  
pp. 330-339
Author(s):  
P. S. Sarao ◽  
J. S. Bentur
Keyword(s):  
Brown Planthopper ◽  
Growth Index ◽  
Resistance Breeding ◽  
Nilaparvata Lugens ◽  
Female Population ◽  
Damage Score ◽  
Survival Percentage ◽  
Honeydew Excretion ◽  
Rice Genotypes ◽  
Better Than

AbstractStudies on different parameters of antibiosis to simultaneously compare diverse genotypes with different resistance levels are lacking. Such studies are necessary to identify the genetic variability among resistant genotypes, which, ultimately, can lead to the identification of resistance genes with diverse mechanisms. The current study was undertaken to quantify antibiosis levels in nine rice genotypes against the brown planthopper (BPH), Nilaparvata lugens (Stål), under glasshouse conditions using nine parameters. Among these genotypes, RP2068-18-3-5 and Ptb33 displayed significantly better performance as compared to other genotypes in most of the parameters studied and did not differ from each other. Rathu Heenati was the best in unfertilised eggs laid and similar to the above two genotypes regarding percent of nymphal survival. All the test genotypes performed significantly better than the susceptible check TN1, though INRC3021 did not differentiate from the former in some tests. The overall damage score was positively and significantly correlated with the amount of honeydew excretion, percent nymphal survival and emergence, the proportion of brachypterous females, female population, and growth index, and were negatively and significantly correlated with percent unfertilised eggs laid and nymphal development period. Regression analysis revealed a significant linear relationship between damage score and nymphal emergence, nymphal survival percentage, and proportion of brachypterous females. RP2068-18-3-5 is the new source of BPH resistance identified through this study, which breeders can further use in resistance breeding.

Natural radioactivity and radiological damage parameters for soil samples from Cekmekoy-İstanbul

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
İskender Akkurt ◽  
Kadir Gunoglu ◽  
Osman Gunay ◽  
Mucize Sarıhan
Keyword(s):  
Natural Radioactivity ◽  
Soil Samples ◽  
Radiological Damage

Role of joint damage, malalignment and inflammation in articular tenderness in rheumatoid arthritis, psoriatic arthritis and osteoarthritis

2021 ◽  
pp. annrheumdis-2020-218744
Author(s):  
Irina Gessl ◽  
Mihaela Popescu ◽  
Victoria Schimpl ◽  
Gabriela Supp ◽  
Thomas Deimel ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Psoriatic Arthritis ◽  
Power Doppler ◽  
Joint Damage ◽  
Joint Space ◽  
Early Arthritis ◽  
Damage Score ◽  
Established Disease ◽  
Active Inflammation

ObjectivesTo determine whether clinical tenderness can be considered a sign of inflammatory joint activity in patients with rheumatoid arthritis (RA), osteoarthritis (OA) or psoriatic arthritis (PsA) and to assess other possible factors associated with tenderness.MethodsPatients diagnosed with RA, PsA and OA underwent clinical and ultrasound examination of wrists and finger joints. Radiographs of the hands were scored for erosions, joint space narrowing (JSN), osteophytes and malalignment. A binary damage score (positive if ≥1 erosion, JSN and/or presence of malalignment) was calculated. Differences in grey scale signs of synovitis and power Doppler (PD) between tender non-swollen (TNS) versus non-tender non-swollen (NTNS) joints were calculated. Disease duration was assessed,<2 years was regarded as early and >5 years as long-standing arthritis.ResultsIn total, 34 patients (9 early and 14 long-standing) from patients with RA, 31 patients (7 early and 15 long-standing) with PsA and 30 with OA were included. We found equal frequencies of PD signal between TNS and NTNS joints in RA (p=0.18), PsA (p=0.59) or OA (p=0.96). However, PD had a significant association with tenderness in early arthritis both in RA (p=0.02) and in PsA (p=0.02). The radiographic damage score showed significant association with tenderness in RA (p<0.01), PsA (p<0.01) and OA (p=0.04).ConclusionTenderness might not always be a sign of active inflammation in RA, PsA and OA. While tenderness in early arthritis may be more related to inflammation, established disease is better explained by joint damage and malalignment.

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