Effect of Local Anesthetics on Platelet Physiology and Function

2021 ◽  
Author(s):  
Ryan C. Dregalla ◽  
Yvette Uribe ◽  
Marko Bodor
Keyword(s):  
Local Anesthetics ◽  
And Function ◽  
Platelet Physiology

REMOVED: Characterisation of the Age-Specific Differences in Platelet Physiology and Function

2014 ◽  
Vol 133 ◽  
pp. S91
Author(s):  
C. Yip ◽  
V. Ignjatovic ◽  
C. Attard ◽  
V. Karlaftis ◽  
M. Linden ◽  
...  
Keyword(s):  
And Function ◽  
Platelet Physiology

scholarly journals Effects of Heat on Platelet Structure and Function

Blood ◽  
1968 ◽  
Vol 32 (2) ◽  
pp. 324-335 ◽  
Author(s):  
JAMES G. WHITE
Keyword(s):  
Platelet Function ◽  
Microscopic Observation ◽  
Electron Microscopic Observation ◽  
Structure And Function ◽  
Electron Microscopic ◽  
Destructive Effect ◽  
And Function ◽  
Platelet Structure ◽  
Platelet Physiology

Abstract The destructive effect of heat on platelet function was established by early investigators. Warming platelets to temperatures above 42 C. was found to destroy their clot-retracting capacity. In the present study, electron microscopic observation has been correlated with tests of platelet function to determine the basis of the damaging effect of heat on platelet physiology. Platelets exposed to temperatures above 42 C. for brief periods lose their discoid shape and become irregularly swollen. The granules of heated platelets are transported to the cell centers where they fuse together. Heat-altered platelets do not aggregate in response to ADP or thrombin and will not retract clots.

Removal notice to “Characterisation of the Age-Specific Differences in Platelet Physiology and Function” [Thromb. Res. 133 (2014) S91]

2015 ◽  
Vol 136 (5) ◽  
pp. 1045
Author(s):  
C. Yip ◽  
V. Ignjatovic ◽  
C. Attard ◽  
V. Karlaftis ◽  
M. Linden ◽  
...  
Keyword(s):  
And Function ◽  
Platelet Physiology

MicroRNAs in Platelet Physiology and Function

2016 ◽  
Vol 42 (03) ◽  
pp. 215-222 ◽  
Author(s):  
Cory Lindsay ◽  
Leonard Edelstein
Keyword(s):  
And Function ◽  
Platelet Physiology

Conformation of Ribosomes from Escherichia Coli

1974 ◽  
Vol 32 ◽  
pp. 210-211
Author(s):  
M. Boublik ◽  
W. Hellmann ◽  
F. Jenkins
Keyword(s):  
Binding Sites ◽  
Ribosomal Proteins ◽  
Fluorescent Dyes ◽  
Protein Biosynthesis ◽  
Three Dimensional ◽  
Spatial Arrangement ◽  
Dimensional Structure ◽  
Complete Understanding ◽  
And Function

The present knowledge of the three-dimensional structure of ribosomes is far too limited to enable a complete understanding of the various roles which ribosomes play in protein biosynthesis. The spatial arrangement of proteins and ribonuclec acids in ribosomes can be analysed in many ways. Determination of binding sites for individual proteins on ribonuclec acid and locations of the mutual positions of proteins on the ribosome using labeling with fluorescent dyes, cross-linking reagents, neutron-diffraction or antibodies against ribosomal proteins seem to be most successful approaches. Structure and function of ribosomes can be correlated be depleting the complete ribosomes of some proteins to the functionally inactive core and by subsequent partial reconstitution in order to regain active ribosomal particles.

The Effect of Oxidized Cholesterol on the Aorta of Rabbits- Scanning Electron Microscopic Observations

1982 ◽  
Vol 40 ◽  
pp. 340-341
Author(s):  
S. K. Pena ◽  
C. B. Taylor ◽  
J. Hill ◽  
J. Safarik
Keyword(s):  
Cholesterol Biosynthesis ◽  
Cholesterol Content ◽  
Arterial Injury ◽  
Electron Microscopic ◽  
Aortic Smooth Muscle ◽  
Oxidized Cholesterol ◽  
Initial Event ◽  
Membrane Structure And Function ◽  
Scanning Electron Microscopic ◽  
And Function

Introduction: Oxidized cholesterol derivatives have been demonstrated in various cell cultures to be very potent inhibitors of 3-hvdroxy-3- methylglutaryl Coenzyme A reductase which is a principle regulator of cholesterol biosynthesis in the cell. The cholesterol content in the cells exposed to oxidized cholesterol was found to be markedly decreased. In aortic smooth muscle cells, the potency of this effect was closely related to the cytotoxicity of each derivative. Furthermore, due to the similarity of their molecular structure to that of cholesterol, these oxidized cholesterol derivatives might insert themselves into the cell membrane, alter membrane structure and function and eventually cause cell death. Arterial injury has been shown to be the initial event of atherosclerosis.

Ultrastructure of developing visual cortical synapses in the cat superior colliculus

1991 ◽  
Vol 49 ◽  
pp. 156-157
Author(s):  
Caroline A. Miller ◽  
Laura L. Bruce
Keyword(s):  
Superior Colliculus ◽  
Phosphate Buffer ◽  
Receptive Fields ◽  
Visual Cortical Area ◽  
Cortical Synapses ◽  
Visual Cortical ◽  
And Function ◽  
Phosphate Buffered Saline ◽  
The Brain ◽  
Cat Superior Colliculus

The first visual cortical axons arrive in the cat superior colliculus by the time of birth. Adultlike receptive fields develop slowly over several weeks following birth. The developing cortical axons go through a sequence of changes before acquiring their adultlike morphology and function. To determine how these axons interact with neurons in the colliculus, cortico-collicular axons were labeled with biocytin (an anterograde neuronal tracer) and studied with electron microscopy.Deeply anesthetized animals received 200-500 nl injections of biocytin (Sigma; 5% in phosphate buffer) in the lateral suprasylvian visual cortical area. After a 24 hr survival time, the animals were deeply anesthetized and perfused with 0.9% phosphate buffered saline followed by fixation with a solution of 1.25% glutaraldehyde and 1.0% paraformaldehyde in 0.1M phosphate buffer. The brain was sectioned transversely on a vibratome at 50 μm. The tissue was processed immediately to visualize the biocytin.

Structural modifications of intercellular junctions.

1978 ◽  
Vol 36 (2) ◽  
pp. 330-331
Author(s):  
J. Metz ◽  
M. Merlo ◽  
W. G. Forssmann
Keyword(s):  
Gap Junctions ◽  
Intercellular Junctions ◽  
Cell Isolation ◽  
Extrahepatic Cholestasis ◽  
Structural Modifications ◽  
Pancreatic Duct Ligation ◽  
Pancreatic Cells ◽  
Duct Ligation ◽  
Thin Sectioning ◽  
And Function

Structure and function of intercellular junctions were studied under the electronmicroscope using conventional thin sectioning and freeze-etch replicas. Alterations of tight and gap junctions were analyzed 1. of exocrine pancreatic cells under cell isolation conditions and pancreatic duct ligation and 2. of hepatocytes during extrahepatic cholestasis.During the different steps of cell isolation of exocrine pancreatic cells, gradual changes of tight and gap junctions were observed. Tight junctions, which formed belt-like structures around the apex of control acinar cells in situ, subsequently diminished, became interrupted and were concentrated into macular areas (Fig. 1). Aggregations of membrane associated particles, which looked similar to gap junctions, were intermixed within tight junctional areas (Fig. 1). These structures continously disappeared in the last stages of the isolation procedure. The intercellular junctions were finally separated without destroying the integrity of the cell membrane, which was confirmed with porcion yellow, lanthanum chloride and horse radish peroxidase.

Sign in / Sign up

Export Citation Format

Share Document