Increased volume and collagen crosslinks drive soft tissue contribution to post‐traumatic elbow contracture in an animal model

2020 ◽  
Author(s):  
Chelsey L. Dunham ◽  
Heiko Steenbock ◽  
Jürgen Brinckmann ◽  
Alex J. Reiter ◽  
Ryan M. Castile ◽  
...  
Keyword(s):  
Animal Model ◽  
Soft Tissue ◽  
Collagen Crosslinks ◽  
Post Traumatic ◽  
Elbow Contracture

scholarly journals Pronation–Supination Motion Is Altered in a Rat Model of Post-Traumatic Elbow Contracture

2017 ◽  
Vol 139 (7) ◽  
Author(s):  
Chelsey L. Dunham ◽  
Ryan M. Castile ◽  
Aaron M. Chamberlain ◽  
Leesa M. Galatz ◽  
Spencer P. Lake
Keyword(s):  
Animal Model ◽  
Soft Tissues ◽  
Lateral Collateral Ligament ◽  
Human Condition ◽  
Joint Contracture ◽  
Elbow Injury ◽  
Flexion Extension ◽  
Post Traumatic ◽  
Elbow Contracture ◽  
Anterior Capsulotomy

The elbow joint is highly susceptible to joint contracture, and treating elbow contracture is a challenging clinical problem. Previously, we established an animal model to study elbow contracture that exhibited features similar to the human condition including persistent decreased range of motion (ROM) in flexion–extension and increased capsule thickness/adhesions. The objective of this study was to mechanically quantify pronation–supination in different injury models to determine if significant differences compared to control or contralateral persist long-term in our animal elbow contracture model. After surgically inducing soft tissue damage in the elbow, Injury I (anterior capsulotomy) and Injury II (anterior capsulotomy with lateral collateral ligament transection), limbs were immobilized for 6 weeks (immobilization (IM)). Animals were evaluated after the IM period or following an additional 6 weeks of free mobilization (FM). Total ROM for pronation–supination was significantly decreased compared to the uninjured contralateral limb for both IM and FM, although not different from control limbs. Specifically, for both IM and FM, total ROM for Injury I and Injury II was significantly decreased by ∼20% compared to contralateral. Correlations of measurements from flexion–extension and pronation–supination divulged that FM did not affect these motions in the same way, demonstrating that joint motions need to be studied/treated separately. Overall, injured limbs exhibited persistent motion loss in pronation–supination when comparing side-to-side differences, similar to human post-traumatic joint contracture. Future work will use this animal model to study how elbow periarticular soft tissues contribute to contracture.

scholarly journals Rotator Cuff Tendinosis in an Animal Model: The Role of Extrinsic and Overuse Factors

2000 ◽  
Author(s):  
S. Thomopoulos ◽  
A. Esmail ◽  
J. D. Williamson ◽  
C. L. Flanagan ◽  
J. P. Iannotti ◽  
...  
Keyword(s):  
Animal Model ◽  
Soft Tissue ◽  
Rotator Cuff ◽  
Musculoskeletal System ◽  
Soft Tissue Injuries ◽  
Rotator Cuff Disease ◽  
Extrinsic Compression ◽  
In Vivo Animal Model

Abstract One of the most common soft tissue injuries of the musculoskeletal system is injury to the rotator cuff tendons of the shoulder. These injuries are commonly attributed to factors such as overuse activity and extrinsic compression. Previous studies on the rotator cuff have been based on surgical reconstructive or clinical retrospective standpoints and were not designed to test hypotheses related to the causes of rotator cuff tendinosis. Our previous study has identified the rat as an appropriate in vivo animal model in which to study rotator cuff disease based on anatomic and functional similarities [1]. The current study uses this animal model to study the roles of extrinsic compression, overuse, and overuse combined with extrinsic compression, on the development of rotator cuff tendinosis. It was hypothesized that a single injury factor would be insufficient to create persistent tendinosis and a combination of injury factors would be necessary.

scholarly journals Post-traumatic posterior heel soft tissue defect reconstruction

2005 ◽  
Vol 38 (2) ◽  
pp. 138
Author(s):  
UH Vyas ◽  
MP Suri ◽  
AG Patel ◽  
HJ Vora ◽  
SC Raibagkar ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Defect ◽  
Tissue Defect ◽  
Defect Reconstruction ◽  
Post Traumatic

scholarly journals Post-traumatic osteoarthritis (PTOA) animal model to understand pathophysiology of osteoarthritis

2019 ◽  
Vol 7 (S3) ◽  
pp. S81-S81
Author(s):  
Quante Singleton ◽  
Santul Bapat ◽  
Sadanand Fulzele
Keyword(s):  
Animal Model ◽  
Post Traumatic

Effects of monopolar radiofrequency treatment over soft-tissue fillers in an animal model: Part 1

2005 ◽  
Vol 37 (5) ◽  
pp. 356-365 ◽  
Author(s):  
Laura J. England ◽  
Mei-Heng Tan ◽  
Peter R. Shumaker ◽  
Barbara M. Egbert ◽  
Kim Pittelko ◽  
...  
Keyword(s):  
Animal Model ◽  
Soft Tissue ◽  
Radiofrequency Treatment

scholarly journals Post-traumatic posterior heel soft tissue defect reconstruction

2005 ◽  
Vol 38 (02) ◽  
pp. 138-143
Author(s):  
M P Suri ◽  
A G Patel ◽  
H J Vora ◽  
S C Raibagkar ◽  
D R Mehta ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Simple Algorithm ◽  
Soft Tissue Defect ◽  
Defect Size ◽  
Suitable Method ◽  
Soft Tissue Coverage ◽  
Associated Injuries ◽  
Exact Location ◽  
Post Traumatic ◽  
Heel Reconstruction

ABSTRACTWe present a simple algorithm for management of post-traumatic posterior heel defect. We covered these with various flaps depending upon the defect size, its exact location, associated injuries, extent of zone of trauma, and complexity of the defect. The aim was to select the most suitable method for soft tissue coverage for posterior heel reconstruction.

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