scholarly journals Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS‐2/8 Chondrosarcoma Cells

2019 ◽  
Vol 38 (5) ◽  
pp. 1045-1051
Author(s):  
William P. Shield ◽  
Ashley Cellini ◽  
Hongying Tian ◽  
Kim Wilson ◽  
Yang Dan ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Selective Agonists

scholarly journals Effect of Specific Retinoic Acid Receptor Agonists on Noise-Induced Hearing Loss

2019 ◽  
Vol 16 (18) ◽  
pp. 3428 ◽  
Author(s):  
Sang Hyun Kwak ◽  
Gi-Sung Nam ◽  
Seong Hoon Bae ◽  
Jinsei Jung
Keyword(s):  
Hearing Loss ◽  
Retinoic Acid ◽  
Noise Exposure ◽  
Retinoic Acid Receptor ◽  
Protective Effects ◽  
Noise Induced Hearing Loss ◽  
Acid Receptor ◽  
Significant Difference ◽  
Brainstem Response ◽  
Selective Agonists

Noise is one of the most common causes of hearing loss in industrial countries. There are many studies about chemical agents to prevent noise-induced hearing loss (NIHL). However, there is no commercially available drug yet. Retinoic acid is an active metabolite of Vitamin A; it has an anti-apoptic role in NIHL. This study aims to verify the differences among selective agonists of retinoic acid receptors (RARs) in NIHL. All-trans retinoic acid (ATRA), AM80 (selective retinoic acid receptor α agonist), AC261066 (Selective retinoic acid receptor β1 agonist), and CD1530 (Selective retinoic acid λ agonist) were injected to 6–7 weeks old CJ5BL/6 mice before noise (110 dB for 3 h) exposure. In the auditory brainstem response test pre-, post 1, 3, and 7 days after noise exposure, not only ATRA but all kinds of selective RAR agonists showed protective effects in hearing threshold and wave I amplitude. Though there was no significant difference in the level of protective effects between agonists, α agonist showed the most prominent effect in preserving hearing function as well as outer hair cells after noise exposure. In conclusion, selective agonists of RAR demonstrate comparable protective effects against NIHL to retinoic acid. Given that these selective RAR agonists have less side effects than retinoic acid, they may be promising potential drugs against NIHL.

scholarly journals Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists

1999 ◽  
Vol 6 (8) ◽  
pp. 519-529 ◽  
Author(s):  
Martine Géhin ◽  
Valérie Vivat ◽  
Jean-Marie Wurtz ◽  
Régine Losson ◽  
Pierre Chambon ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Structural Basis ◽  
Acid Receptor ◽  
Selective Agonists

Contribution of retinoic acid receptor signalling to adrenal cortex morphology and functional zonation through modulation of WNT/[beta]-catenin pathway

2017 ◽  
Author(s):  
Zein Rami El ◽  
Amanda J Rickard ◽  
Golib Dzib Jose Felipe ◽  
Benoit Samson-Couterie ◽  
Angelique Rocha ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Adrenal Cortex ◽  
Retinoic Acid Receptor ◽  
Beta Catenin ◽  
Acid Receptor ◽  
Receptor Signalling
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