scholarly journals Effect of interface mechanical discontinuities on scaffold‐cartilage integration

2019 ◽  
Vol 37 (4) ◽  
pp. 845-854 ◽  
Author(s):  
Supansa Yodmuang ◽  
Hongqiang Guo ◽  
Caroline Brial ◽  
Russell F. Warren ◽  
Peter A. Torzilli ◽  
...  
Keyword(s):  
Cartilage Integration

Tissue Engineered Cartilage Integration to Live and Devitalized Cartilage: A Study by Reflectance Mode Confocal Microscopy and Standard Histology

2006 ◽  
Vol 47 (4) ◽  
pp. 190-199 ◽  
Author(s):  
Giuseppe M. Peretti ◽  
Vanessa Campo-Ruiz ◽  
Salvador Gonzalez ◽  
Mark A. Randolph ◽  
Jian Wei Xu ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Engineered Cartilage ◽  
Cartilage Integration

Catechol-modified poly(oxazoline)s with tunable degradability facilitate cell invasion and lateral cartilage integration

2019 ◽  
Vol 80 ◽  
pp. 757-769 ◽  
Author(s):  
Oliver Berberich ◽  
Julia Blöhbaum ◽  
Stefanie Hölscher-Doht ◽  
Rainer H. Meffert ◽  
Jörg Teßmar ◽  
...  
Keyword(s):  
Cell Invasion ◽  
Lateral Cartilage ◽  
Cartilage Integration

A Collagen Fiber Membrane Aided Chondroprotective-Based Strategy for Enhancing Integration of Regenerative Neo-Cartilage

2020 ◽  
Vol 16 (5) ◽  
pp. 672-688
Author(s):  
Wenyu Yang ◽  
Ziqiang Wang ◽  
Fuchong Du ◽  
Yiting Cao ◽  
Bo Du ◽  
...  
Keyword(s):  
Growth Factor ◽  
Delivery System ◽  
Subchondral Bone ◽  
Targeted Delivery ◽  
Collagen Fiber ◽  
New Technologies ◽  
Fiber Membrane ◽  
The Impact ◽  
Cartilage Integration ◽  
Host Tissues

The lack of neo-cartilage integration with host tissues is a great challenge for the clinical translation of new technologies for the repair of articular cartilage (AC) defect. Recently, we developed a promising double-layered collagen-based system for targeted delivery of fibroblast growth factor 2 (FGF2) to the subchondral bone for AC repair. The system effectively promoted the regeneration of both cartilage and subchondral bone. However, neo-cartilage integration was unsatisfactory, which might be due to the presence of a zone of cell death (ZCD) in the cartilage induced by injury. Here, we hypothesized that maintaining cell viability in the region surrounding the defect and decreasing the size of ZCD by using chondroprotective agents such as insulin-like growth factor-1 (IGF-1), might be an effective strategy to improve neo-cartilage integration. A targeted delivery system for IGF-1 to cartilage based on the FGF2 delivery system was formulated to weaken the impact on the effects of FGF2. The two growth factors were incorporated into the different layers of the membrane without interdiffusion. Due to the different densities of collagen fibers in the different layers, the in vitro and in vivo assays demonstrated that both proteins were released via unidirectional diffusion without mixing or lateral diffusion. Particularly, the released IGF-1 increased the viability of chondrocytes, decreased the ZCD size, and enhanced the integration of regenerative neo-cartilage with host tissues, without any undesirable effects on the FGF2mediated regeneration of cartilage and subchondral bone. Taken together, our findings demonstrate that the collagen fiber membrane-aided chondroprotective-based strategy is an effective way to improve neo-cartilage integration.

Continuous Low-Intensity Ultrasound Promotes Native-to-Native Cartilage Integration

2019 ◽  
Vol 25 (21-22) ◽  
pp. 1538-1549 ◽  
Author(s):  
Neety Sahu ◽  
April Miller ◽  
Hendrik J. Viljoen ◽  
Anuradha Subramanian
Keyword(s):  
Low Intensity ◽  
Native Cartilage ◽  
Low Intensity Ultrasound ◽  
Cartilage Integration

scholarly journals Polymeric mesh and insulin‐like growth factor 1 delivery enhance cell homing and graft−cartilage integration

2019 ◽  
Vol 1442 (1) ◽  
pp. 138-152 ◽  
Author(s):  
Margaret K. Boushell ◽  
Christopher Z. Mosher ◽  
Gurbani K. Suri ◽  
Stephen B. Doty ◽  
Eric J. Strauss ◽  
...  
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Cell Homing ◽  
Cartilage Integration

scholarly journals Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration

2021 ◽  
Vol 6 (1) ◽  
pp. 6
Author(s):  
Graziana Monaco ◽  
Alicia J. El Haj ◽  
Mauro Alini ◽  
Martin J. Stoddart
Keyword(s):  
Articular Cartilage ◽  
Chondrogenic Differentiation ◽  
Ex Vivo ◽  
Cartilage Regeneration ◽  
Therapeutic Interventions ◽  
Surrounding Tissue ◽  
Self Healing ◽  
Culture Models ◽  
Articular Cartilage Injury ◽  
Cartilage Integration

Articular cartilage injury and repair is an issue of growing importance. Although common, defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity, which is largely due to its avascular nature. There is a critical need to better study and understand cellular healing mechanisms to achieve more effective therapies for cartilage regeneration. This article aims to describe the key features of cartilage which is being modelled using tissue engineered cartilage constructs and ex vivo systems. These models have been used to investigate chondrogenic differentiation and to study the mechanisms of cartilage integration into the surrounding tissue. The review highlights the key regeneration principles of articular cartilage repair in healthy and diseased joints. Using co-culture models and novel bioreactor designs, the basis of regeneration is aligned with recent efforts for optimal therapeutic interventions.

Steroid hormones strongly support bovine articular cartilage integration in the absence of interleukin-1β

2006 ◽  
Vol 54 (12) ◽  
pp. 3890-3897 ◽  
Author(s):  
Carsten Englert ◽  
Torsten Blunk ◽  
Johann Fierlbeck ◽  
Julia Kaiser ◽  
Wolfgang Stosiek ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Steroid Hormones ◽  
Interleukin 1Β ◽  
Bovine Articular Cartilage ◽  
Cartilage Integration

scholarly journals The Role of Platelet-Rich Plasma in Promoting Cartilage Integration and Chondrocyte Migration

2017 ◽  
Vol 5 (7_suppl6) ◽  
pp. 2325967117S0022 ◽  
Author(s):  
Corey Sermer ◽  
Rita Kandel ◽  
Jesse Anderson ◽  
Mark Hurtig ◽  
John S. Theodoropoulos
Keyword(s):  
Platelet Rich Plasma ◽  
Chondrocyte Migration ◽  
Cartilage Integration
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