scholarly journals Enhancing the effects of exfoliated carbon nanofibers using bone morphogenetic protein in a rat spinal fusion model

2018 ◽  
Vol 36 (11) ◽  
pp. 2892-2900
Author(s):  
Naoki Notani ◽  
Masashi Miyazaki ◽  
Masahiro Toyoda ◽  
Shozo Kanezaki ◽  
Toshinobu Ishihara ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Bone Morphogenetic Protein ◽  
Carbon Nanofibers ◽  
Fusion Model ◽  
Morphogenetic Protein

Manipulation of anabolic and catabolic responses with bone morphogenetic protein and zoledronic acid in a rat spinal fusion model

Bone ◽  
2014 ◽  
Vol 58 ◽  
pp. 26-32 ◽  
Author(s):  
Ryuzo Kodera ◽  
Masashi Miyazaki ◽  
Toyomi Yoshiiwa ◽  
Masanori Kawano ◽  
Nobuhiro Kaku ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Spinal Fusion ◽  
Bone Morphogenetic Protein ◽  
Fusion Model ◽  
Morphogenetic Protein

scholarly journals Engineered bridge protein with dual affinity for bone morphogenetic protein-2 and collagen enhances bone regeneration for spinal fusion

2021 ◽  
Vol 7 (24) ◽  
pp. eabh4302
Author(s):  
Priscilla S. Briquez ◽  
Hsiu-Ming Tsai ◽  
Elyse A. Watkins ◽  
Jeffrey A. Hubbell
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Spinal Fusion ◽  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
High Dose ◽  
Fusion Model ◽  
Safety Issues ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein

The revolutionizing efficacy of recombinant human bone morphogenetic protein (rhBMP-2) for clinical spinal fusion is hindered by safety issues associated with the high dose required. However, it continues to be widely used, for example, in InFUSE Bone Graft (Medtronic). Here, we developed a translational protein engineering–based approach to reduce the dose and thereby improve the safety of rhBMP-2 delivered in a collagen sponge, as in InFUSE Bone Graft. We engineered a bridge protein with high affinity for rhBMP-2 and collagen that can be simply added to the product’s formulation, demonstrating improved efficacy at low dose of rhBMP-2 in two mouse models of bone regeneration, including a newly developed spinal fusion model. Moreover, the bridge protein can control the retention of rhBMP-2 from endogenous collagenous extracellular matrix of tissue. Our approach may be generalizable to other growth factors and collagen-based materials, for use in many other applications in regenerative medicine.

Sign in / Sign up

Export Citation Format

Share Document