Biomechanical investigation of two long bone growth modulation techniques by finite element simulations

2017 ◽  
Vol 36 (5) ◽  
pp. 1398-1405 ◽  
Author(s):  
Manuel Schneider ◽  
Jan Buschbaum ◽  
Alexander Joeris ◽  
Oliver Röhrle ◽  
Jonathan Dwyer ◽  
...  
Keyword(s):  
Finite Element ◽  
Bone Growth ◽  
Finite Element Simulations ◽  
Long Bone ◽  
Growth Modulation ◽  
Biomechanical Investigation ◽  
Modulation Techniques

scholarly journals Altered paracrine signaling from the injured knee joint impairs postnatal long bone growth

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Alberto Roselló-Díez ◽  
Daniel Stephen ◽  
Alexandra L Joyner
Keyword(s):  
Knee Joint ◽  
Internal Control ◽  
Bone Growth ◽  
Long Bone ◽  
Paracrine Signaling ◽  
Growth Modulation ◽  
Genetic Mouse Model ◽  
Mesenchyme Cells ◽  
Injured Knee ◽  
The Right

Regulation of organ growth is a poorly understood process. In the long bones, the growth plates (GPs) drive elongation by generating a scaffold progressively replaced by bone. Although studies have focused on intrinsic GP regulation, classic and recent experiments suggest that local signals also modulate GP function. We devised a genetic mouse model to study extrinsic long bone growth modulation, in which injury is specifically induced in the left hindlimb, such that the right hindlimb serves as an internal control. Remarkably, when only mesenchyme cells surrounding postnatal GPs were killed, left bone growth was nevertheless reduced. GP signaling was impaired by altered paracrine signals from the knee joint, including activation of the injury response and, in neonates, dampened IGF1 production. Importantly, only the combined prevention of both responses rescued neonatal growth. Thus, we identified signals from the knee joint that modulate bone growth and could underlie establishment of body proportions.

Thermomechanical finite element simulations of ultrasonically assisted turning

2005 ◽  
Vol 32 (3-4) ◽  
pp. 463-471 ◽  
Author(s):  
A.V. Mitrofanov ◽  
V.I. Babitsky ◽  
V.V. Silberschmidt
Keyword(s):  
Finite Element ◽  
Finite Element Simulations

Mechanical Testing and Finite Element Simulations for the Use of Cellular Metals as Car Seat Components

2012 ◽  
Vol 83 (10) ◽  
pp. 972-980 ◽  
Author(s):  
Srecko Nesic ◽  
Klaus Unruh ◽  
Wilhelm Michels ◽  
Ulrich Krupp
Keyword(s):  
Finite Element ◽  
Mechanical Testing ◽  
Finite Element Simulations ◽  
Car Seat ◽  
Cellular Metals

Identifying and reducing critical lag in finite element simulations

1996 ◽  
Vol 16 (4) ◽  
pp. 67-71 ◽  
Author(s):  
V.E. Taylor ◽  
Jian Chen ◽  
Milana Huang ◽  
T. Canfield ◽  
R. Stevens
Keyword(s):  
Finite Element ◽  
Finite Element Simulations

scholarly journals Characterizing material liberation of multi-material lightweight structures from shredding experiments and finite element simulations

2021 ◽  
Vol 172 ◽  
pp. 107142
Author(s):  
Magdalena Heibeck ◽  
Martin Rudolph ◽  
Niels Modler ◽  
Markus Reuter ◽  
Angelos Filippatos
Keyword(s):  
Finite Element ◽  
Finite Element Simulations ◽  
Lightweight Structures
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