Binding and lubrication of biomimetic boundary lubricants on articular cartilage

Kirk J. Samaroo; Mingchee Tan; David Putnam; Lawrence J. Bonassar

doi:10.1002/jor.23370

Binding and lubrication of biomimetic boundary lubricants on articular cartilage

Journal of Orthopaedic Research® ◽

10.1002/jor.23370 ◽

2016 ◽

Vol 35 (3) ◽

pp. 548-557 ◽

Cited By ~ 21

Author(s):

Kirk J. Samaroo ◽

Mingchee Tan ◽

David Putnam ◽

Lawrence J. Bonassar

Keyword(s):

Articular Cartilage ◽

Boundary Lubricants

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Normal and Shear Interactions between Hyaluronan–Aggrecan Complexes Mimicking Possible Boundary Lubricants in Articular Cartilage in Synovial Joints

Biomacromolecules ◽

10.1021/bm301283f ◽

2012 ◽

Vol 13 (11) ◽

pp. 3823-3832 ◽

Cited By ~ 44

Author(s):

Jasmine Seror ◽

Yulia Merkher ◽

Nir Kampf ◽

Lisa Collinson ◽

Anthony J. Day ◽

...

Keyword(s):

Articular Cartilage ◽

Synovial Joints ◽

Boundary Lubricants

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Articular Cartilage Proteoglycans As Boundary Lubricants: Structure and Frictional Interaction of Surface-Attached Hyaluronan and Hyaluronan–Aggrecan Complexes

Biomacromolecules ◽

10.1021/bm2004912 ◽

2011 ◽

Vol 12 (10) ◽

pp. 3432-3443 ◽

Cited By ~ 81

Author(s):

Jasmine Seror ◽

Yulia Merkher ◽

Nir Kampf ◽

Lisa Collinson ◽

Anthony J. Day ◽

...

Keyword(s):

Articular Cartilage ◽

Frictional Interaction ◽

Boundary Lubricants ◽

Cartilage Proteoglycans

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The Effect of Total Meniscectomy versus Caudal Pole Hemimeniscectomy on the Stifle Joint of the Sheep

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1632463 ◽

1999 ◽

Vol 12 (02) ◽

pp. 56-63 ◽

Cited By ~ 5

Author(s):

C. R. Bellenger ◽

P. Ghosh ◽

Y. Numata ◽

C. Little ◽

D. S. Simpson

Keyword(s):

Tissue Culture ◽

Articular Cartilage ◽

Fibrous Tissue ◽

Cartilage Degeneration ◽

Medial Compartment ◽

Proteoglycan Synthesis ◽

Stifle Joint ◽

Medial Meniscectomy ◽

Tibial Condyle ◽

Articular Cartilage Degeneration

SummaryTotal medial meniscectomy and caudal pole hemimeniscectomy were performed on the stifle joints of twelve sheep. The two forms of meniscectomy produced a comparable degree of postoperative lameness that resolved within two weeks of the operations. After six months the sheep were euthanatised and the stifle joints examined. Fibrous tissue that replaced the excised meniscus in the total meniscectomy group did not cover as much of the medial tibial condyle as the residual cranial pole and caudal fibrous tissue observed following hemimeniscectomy. The articular cartilage from different regions within the joints was examined for gross and histological evidence of degeneration. Analyses of the articular cartilage for water content, glycosaminoglycan composition and DNA content were performed. The proteoglycan synthesis and release from explanted articular cartilage samples in tissue culture were also measured. There were significant pathological changes in the medial compartment of all meniscectomised joints. The degree of articular cartilage degeneration that was observed following total meniscectomy and caudal pole meniscectomy was similar. Caudal pole hemimeniscectomy, involving transection of the meniscus, causes the same degree of degeneration of the stifle joint that occurs following total meniscectomy.The effect of total medial meniscectomy versus caudal pole hemimeniscectomy on the stifle joint of sheep was studied experimentally. Six months after the operations gross pathology, histopathology, cartilage biochemical analysis and the rate of proteoglycan synthesis in tissue culture were used to compare the articular cartilage harvested from the meniscectomised joints. Degeneration of the articular cartilage from the medial compartment of the joints was present in both of the groups. Caudal pole hemimeniscectomy induces a comparable degree of articular cartilage degeneration to total medial meniscectomy in the sheep stifle joint.

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