Unilateral versus bilateral percutaneous kyphoplasty for osteoporotic vertebral compression fractures: A systematic review and meta‐analysis of RCTs

2015 ◽  
Vol 33 (11) ◽  
pp. 1713-1723 ◽  
Author(s):  
Hui Feng ◽  
Peng Huang ◽  
Xuesong Zhang ◽  
Guoquan Zheng ◽  
Yan Wang
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Vertebral Compression Fractures ◽  
Osteoporotic Vertebral Compression Fractures ◽  
Compression Fractures ◽  
Percutaneous Kyphoplasty

scholarly journals Is Unilateral Percutaneous Kyphoplasty Superior to Bilateral Percutaneous Kyphoplasty for Osteoporotic Vertebral Compression Fractures? Evidence from a Systematic Review of Discordant Meta-Analyses

2018 ◽  
Vol 1 (21;1) ◽  
pp. 327-336 ◽  
Author(s):  
Dongling Cai
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Vertebral Compression Fractures ◽  
Osteoporotic Vertebral Compression Fractures ◽  
Decision Algorithm ◽  
Compression Fractures ◽  
Percutaneous Kyphoplasty ◽  
Similar Good ◽  
Meta Analyses

Background: Several meta-analyses have been performed to compare unilateral percutaneous kyphoplasty (PKP) and bilateral PKP in the treatment of osteoporotic vertebral compression fractures (OVCFs), but inconsistencies in the results have led to questions as to which technique is preferable. Objective: This study was designed to clarify the benefits and disadvantages of unilateral PKP versus bilateral PKP as found in numerous discordant meta-analyses and thereby present surgical treatment recommendations for OVCFs considering the current best evidence. Study Design: Systematic review/Meta-analysis. Methods: Meta-analyses on unilateral and bilateral PKP for OVCFs were included by searching Pubmed, Embase, and Cochrane library. Meta-analysis quality was assessed using Oxford Levels of Evidence and Assessment of Multiple Systematic Reviews (AMSTAR). The Jadad decision algorithm was used to identify the best evidence. Results: Eight eligible meta-analyses were included, 7 of which were Level-II evidence and one was Level-III evidence. The AMSTAR scores varied from 7 to 8. The Jadad decision algorithm suggested that the best meta-analysis should be selected depending upon publication characteristics and methodology of primary studies, language restrictions, and whether data analysis was performed on individual patients. The best available evidence indicated that both unilateral and bilateral PKP could receive similar good clinical and radiological outcomes. However, without increasing the risk of complications, unilateral PKP required shorter surgical time and less cement volume, offering better pain relief and quality of life at post-operative short term follow-ups. Limitations: Primary studies had defects in their methodologies. Conclusions: Unilateral PKP appears to be superior to bilateral PKP in the treatment of OVCFs. Key words: Osteoporotic vertebral compression fractures, percutaneous kyphoplasty, meta-analysis

scholarly journals Zoledronic Acid in Osteoporotic Vertebral Compression Fractures Treated With Percutaneous Kyphoplasty: A Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Peng Tian ◽  
Yue Liu ◽  
Zhi-jun Li ◽  
Gui-jun Xu ◽  
Xin-long Ma
Keyword(s):  
Zoledronic Acid ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Vertebral Compression Fractures ◽  
Vertebral Augmentation ◽  
Osteoporotic Vertebral Compression Fractures ◽  
Compression Fractures ◽  
Percutaneous Kyphoplasty ◽  
Vertebral Body Fractures

Background: We performed a meta-analysis to evaluate the efficacy and safety of zoledronic acid combined with percutaneous kyphoplasty (PKP) in treating osteoporotic vertebral compression fractures (OVCFs).Methods: Eligible scientific articles published prior to July 2020 were retrieved from the PubMed, Springer, ScienceDirect, and Cochrane Library databases. The statistical analysis was performed with RevMan 5.1.Results: Three randomized controlled trials (RCTs) and 2 non-RCTs met the inclusion criteria. The present meta-analysis revealed that zoledronic acid combined with PKP is associated with a higher BMD, a better quality of life, less severe low back pain, and fewer additional vertebral body fractures than is percutaneous vertebral augmentation alone.Conclusions: Compared with PKP only, zoledronic acid combined with percutaneous vertebral augmentation is beneficial for OVCFs.

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