Three-dimensional imaging and analysis of human cartilage degeneration using Optical Coherence Tomography

2015 ◽  
Vol 33 (5) ◽  
pp. 651-659 ◽  
Author(s):  
Sven Nebelung ◽  
Nicolai Brill ◽  
Ulrich Marx ◽  
Valentin Quack ◽  
Markus Tingart ◽  
...  
2019 ◽  
Vol 39 (1) ◽  
pp. 0117001 ◽  
Author(s):  
侯方 Hou Fang ◽  
杨子晗 Yang Zihan ◽  
谷文青 Gu Wenqing ◽  
于洋 Yu Yang ◽  
赵敬柱 Zhao Jingzhu ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Junyoung Kim ◽  
Sunwon Kim ◽  
Joon Woo Song ◽  
Hyun Jung Kim ◽  
Min Woo Lee ◽  
...  

2010 ◽  
Vol 18 (3) ◽  
pp. 2782 ◽  
Author(s):  
Sergio Ortiz ◽  
Damian Siedlecki ◽  
Ireneusz Grulkowski ◽  
Laura Remon ◽  
Daniel Pascual ◽  
...  

2003 ◽  
Vol 11 (21) ◽  
pp. 2753 ◽  
Author(s):  
Christoph K. Hitzenberger ◽  
Peter Trost ◽  
Pak-Wai Lo ◽  
Qienyuan Zhou

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Florence de Bont ◽  
Nicolai Brill ◽  
Robert Schmitt ◽  
Markus Tingart ◽  
Björn Rath ◽  
...  

Posttraumatic osteoarthritis constitutes a major cause of disability in our increasingly elderly population. Unfortunately, current imaging modalities are too insensitive to detect early degenerative changes of this disease. Optical coherence tomography (OCT) is a promising nondestructive imaging technique that allows surface and subsurface imaging of cartilage, at near-histological resolution, and is principally applicablein vivoduring arthroscopy. Thirty-four macroscopically normal human cartilage-bone samples obtained from total joint replacements were subjected to standardized single impactsin vitro(range: 0.25 J to 0.98 J). 3D OCT measurements of impact area and adjacent tissue were performed prior to impaction, directly after impaction, and 1, 4, and 8 days later. OCT images were assessed qualitatively (DJD classification) and quantitatively using established parameters (OII, Optical Irregularity Index; OHI, Optical Homogeneity Index; OAI, Optical Attenuation Index) and compared to corresponding histological sections. WhileOAIandOHIscores were not significantly changed in response to low- or moderate-impact energies, high-impact energies significantly increased mean DJD grades (histology and OCT) andOIIscores. In conclusion, OCT-based parameterization and quantification are able to reliably detect loss of cartilage surface integrity after high-energy traumatic insults and hold potential to be used for clinical screening of early osteoarthritis.


2006 ◽  
Vol 11 (3) ◽  
pp. 034001 ◽  
Author(s):  
Chuanwu Xi ◽  
Daniel Marks ◽  
Simon Schlachter ◽  
Wei Luo ◽  
Stephen A. Boppart

Sign in / Sign up

Export Citation Format

Share Document