scholarly journals The involvement of ADAMTS-5 genetic polymorphisms in predisposition and diffusion tensor imaging alterations of lumbar disc degeneration

2014 ◽  
Vol 32 (5) ◽  
pp. 686-694 ◽  
Author(s):  
Nan Wu ◽  
Jun Chen ◽  
Hao Liu ◽  
Luo Zhao ◽  
Sen Liu ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Genetic Polymorphisms ◽  
Disc Degeneration ◽  
Diffusion Tensor ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
And Diffusion

scholarly journals Diffusion-Weighted Imaging and Diffusion Tensor Imaging of Asymptomatic Lumbar Disc Herniation

2000 ◽  
Vol 40 (1.2) ◽  
pp. 197-203
Author(s):  
Toshinori Sakai ◽  
Ryo Miyagi ◽  
Eiko Yamabe ◽  
Yasunari Fujinaga ◽  
Nitin N. Bhatia ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Diffusion Weighted Imaging ◽  
Diffusion Tensor ◽  
Lumbar Disc ◽  
Diffusion Weighted ◽  
And Diffusion

scholarly journals Diffusion-Weighted Imaging and Diffusion Tensor Imaging of Asymptomatic Lumbar Disc Herniation

2014 ◽  
Vol 61 (1.2) ◽  
pp. 197-203 ◽  
Author(s):  
Toshinori Sakai ◽  
Ryo Miyagi ◽  
Eiko Yamabe ◽  
Yasunari Fujinaga ◽  
Nitin N. Bhatia ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Diffusion Weighted Imaging ◽  
Diffusion Tensor ◽  
Lumbar Disc ◽  
Diffusion Weighted ◽  
And Diffusion

Lumbar Disc Degeneration

1990 ◽  
Vol 31 (6) ◽  
pp. 551-554
Author(s):  
O. Tervonen ◽  
S. Lahde ◽  
J. Rydberg
Keyword(s):  
Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration

INTERVERTEBRAL DISC DEGENERATION LINKED TO STRUCTURAL GENE VARIATIONS

2019 ◽  
Author(s):  
Saeeda Baig
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
English Language ◽  
Tandem Repeats ◽  
Lumbar Disc ◽  
Disease Process ◽  
Nucleotide Polymorphisms ◽  
Structural Protein ◽  
Lumbar Disc Degeneration

During the recent past focus has shifted from identifying intervertebral disc degeneration as being caused by physical exposure and strain to being linked with a variety of genetic variations. The objective of this review is to provide an up to date review of the existing research data regarding the relation of intervertebral disc degeneration to structural protein genes and their polymorphisms and thus help clearly establish further avenues where research into causation and treatment is needed. A comprehensive search using the keywords “Collagen”, “COL”, “Aggrecan”, “AGC”, “IVDD”, “intervertebral disc degeneration”, and “lumbar disc degeneration” from PubMed and Google Scholar, where literature in the English language was selected spanning from 1991 to 2019. There are many genes involved in the production of structural components of an intervertebral disc. The issues in production of these components involve the over-expression or under-expression of their genes, and single nucleotide polymorphisms and variable number of tandem repeats affecting their structures. These structural genes include primarily the collagen and the aggrecan genes. While genetic and environmental factors all come into play with a disease process like disc degeneration, the bulk of research now shows the significantly larger impact of hereditary over exposure. While further research is needed into some of the lesser studied genes linked to IVDD and also the racial variations in genetic makeup, the focus in the near future should be on establishment of genetic testing to identify individuals at greater risk of disease and deliberation regarding the use of gene therapy to prevent disc degeneration.

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