scholarly journals Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes

2013 ◽  
Vol 32 (4) ◽  
pp. 573-580 ◽  
Author(s):  
Ying Ju Chen ◽  
Keh Sung Tsai ◽  
Ding Cheng Chan ◽  
Kuo Cheng Lan ◽  
Cheng Feng Chen ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Inflammatory Response ◽  
Natural Product ◽  
Cartilage Matrix ◽  
Low Molecular Weight ◽  
Matrix Degradation ◽  
Osteoarthritis Chondrocytes ◽  
And Cartilage

scholarly journals Silibinin protects against osteoarthritis through inhibiting the inflammatory response and cartilage matrix degradation in vitro and in vivo

Oncotarget ◽  
2017 ◽  
Vol 8 (59) ◽  
pp. 99649-99665 ◽  
Author(s):  
Wenhao Zheng ◽  
Zhenhua Feng ◽  
Yiting Lou ◽  
Chunhui Chen ◽  
Chuanxu Zhang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Cartilage Matrix ◽  
Matrix Degradation ◽  
And Cartilage

Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis

2015 ◽  
Vol 55 (1) ◽  
pp. 315-325 ◽  
Author(s):  
María Angeles Rosillo ◽  
Marina Sánchez-Hidalgo ◽  
Susana Sánchez-Fidalgo ◽  
Marina Aparicio-Soto ◽  
Isabel Villegas ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Cartilage Matrix ◽  
Matrix Degradation ◽  
Collagen Induced Arthritis ◽  
And Cartilage

scholarly journals Location of 64K collagen producer chondrocytes in developing chicken embryo tibiae.

1984 ◽  
Vol 4 (6) ◽  
pp. 1163-1168 ◽  
Author(s):  
O Capasso ◽  
G Tajana ◽  
R Cancedda
Keyword(s):  
Molecular Weight ◽  
Developmental Stage ◽  
Bone Tissue ◽  
Chicken Embryo ◽  
Cartilage Matrix ◽  
Low Molecular Weight ◽  
Specific Developmental Stage ◽  
Cell Biol

The synthesis of a new low-molecular-weight collagen by cultured chicken embryo chondrocytes has been recently demonstrated (Capasso et al., Exp. Cell Res. 142:197-206, 1982; Gibson et al., J. Cell Biol. 93:767-774, 1982; Schmid and Conrad, J. Biol. Chem. 257:12444-12450, 1982). In this paper we report results on the location of chondrocytes synthesizing this new collagen (64K collagen) in the developing chicken embryo. The 64K collagen is synthesized in very large amounts by cells concentrated at the diaphysis of 9-day-old and at the epiphysis of 17-day-old embryo tibiae. These regions are characterized by a remodeling of the cartilage matrix leading to the replacement of the cartilage with bone tissue; therefore, this collagen appears to be a marker of a specific developmental stage of chondrocytes. The origin of cells competent for the synthesis of the 64K collagen is also discussed.

scholarly journals Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis

2014 ◽  
Vol 8 (4) ◽  
pp. 1065-1074 ◽  
Author(s):  
YING XU ◽  
GUO-JING DAI ◽  
QIAN LIU ◽  
ZHEN-LI LIU ◽  
ZHI-QIAN SONG ◽  
...  
Keyword(s):  
Rat Model ◽  
Cartilage Matrix ◽  
Chondrocyte Apoptosis ◽  
Matrix Degradation ◽  
And Cartilage

scholarly journals Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro

2020 ◽  
Vol 21 (3) ◽  
pp. 1036 ◽  
Author(s):  
Jennifer E. Rowley ◽  
Farners Amargant ◽  
Luhan T. Zhou ◽  
Anna Galligos ◽  
Leah E. Simon ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Inflammatory Response ◽  
Granulosa Cell ◽  
Stromal Cells ◽  
Cell Function ◽  
Ovarian Follicles ◽  
Low Molecular Weight ◽  
Reproductive Aging ◽  
Ovarian Stroma

The ovarian stroma, the microenvironment in which female gametes grow and mature, becomes inflamed and fibrotic with age. Hyaluronan is a major component of the ovarian extracellular matrix (ECM), and in other aging tissues, accumulation of low molecular weight (LMW) hyaluronan fragments can drive inflammation. Thus, we hypothesized that LMW hyaluronan fragments contribute to female reproductive aging by stimulating an inflammatory response in the ovarian stroma and impairing gamete quality. To test this hypothesis, isolated mouse ovarian stromal cells or secondary stage ovarian follicles were treated with physiologically relevant (10 or 100 μg/mL) concentrations of 200 kDa LMW hyaluronan. In ovarian stromal cells, acute LMW hyaluronan exposure, at both doses, resulted in the secretion of a predominantly type 2 (Th2) inflammatory cytokine profile as revealed by a cytokine antibody array of conditioned media. Additional qPCR analyses of ovarian stromal cells demonstrated a notable up-regulation of the eotaxin receptor Ccr3 and activation of genes involved in eosinophil recruitment through the IL5-CCR3 signaling pathway. These findings were consistent with an age-dependent increase in ovarian stromal expression of Ccl11, a major CCR3 ligand. When ovarian follicles were cultured in 10 or 100 μg/mL LMW hyaluronan for 12 days, gametes with compromised morphology and impaired meiotic competence were produced. In the 100 μg/mL condition, LMW hyaluronan induced premature meiotic resumption, ultimately leading to in vitro aging of the resulting eggs. Further, follicles cultured in this LMW hyaluronan concentration produced significantly less estradiol, suggesting compromised granulosa cell function. Taken together, these data demonstrate that bioactive LMW hyaluronan fragments may contribute to reproductive aging by driving an inflammatory stromal milieu, potentially through eosinophils, and by directly compromising gamete quality through impaired granulosa cell function.

Low molecular weight chitosan oligosaccharides (LMW-COSs) prevent obesity-related metabolic abnormalities in association with the modification of gut microbiota in high-fat diet (HFD)-fed mice

2020 ◽  
Vol 11 (11) ◽  
pp. 9947-9959
Author(s):  
Ningning He ◽  
Shuo Wang ◽  
Zhiyuan Lv ◽  
Wandong Zhao ◽  
Shangyong Li
Keyword(s):  
Molecular Weight ◽  
Inflammatory Response ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Parameters ◽  
Low Molecular Weight ◽  
Metabolic Abnormalities ◽  
High Fat ◽  
Chitosan Oligosaccharides ◽  
Low Molecular Weight Chitosan

Enzymatic LMW-COSs ameliorate obesity and obesity-related metabolic abnormalities. The overall change in gut microbiota was associated with metabolic parameters and its prebiotic functions by regulating gut microbiota and inflammatory response.

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