scholarly journals Association of a functional polymorphism in the promoter region of TLR-3 with osteoarthritis: A two-stage case-control study

2012 ◽  
Vol 31 (5) ◽  
pp. 680-685 ◽  
Author(s):  
Hsin-Yi Yang ◽  
Herng-Sheng Lee ◽  
Chian-Her Lee ◽  
Wen-Hui Fang ◽  
Hsiang-Cheng Chen ◽  
...  
Keyword(s):  
Promoter Region ◽  
Case Control Study ◽  
Case Control ◽  
Functional Polymorphism ◽  
Two Stage ◽  
Control Study

scholarly journals A Two-Stage Matched Case–Control Study on Multiple Hypertensive Candidate Genes in Han Chinese

2012 ◽  
Vol 25 (7) ◽  
pp. 804-811 ◽  
Author(s):  
Tai-Yue Kuo ◽  
Mei-Jyh Kang ◽  
Jaw-Wen Chen ◽  
Hung-Yun Ho ◽  
Chih-Tai Ting ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Two Stage ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: A two-stage Spanish case–control study

2009 ◽  
Vol 112 (1) ◽  
pp. 210-214 ◽  
Author(s):  
Ana Vega ◽  
Antonio Salas ◽  
Roger L. Milne ◽  
Begoña Carracedo ◽  
Gloria Ribas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Sporadic Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Candidate Snps ◽  
Two Stage ◽  
Control Study

Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene in alcohol dependence: Family and case control study

2010 ◽  
Vol 1327 ◽  
pp. 103-106 ◽  
Author(s):  
Agnieszka Samochowiec ◽  
Anna Grzywacz ◽  
Leszek Kaczmarek ◽  
Przemyslaw Bienkowski ◽  
Jerzy Samochowiec ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Alcohol Dependence ◽  
Case Control Study ◽  
Case Control ◽  
Matrix Metalloproteinase 9 ◽  
Functional Polymorphism ◽  
Metalloproteinase 9 ◽  
Control Study

scholarly journals Two-stage case–control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk

2009 ◽  
Vol 121 (3) ◽  
pp. 765-769 ◽  
Author(s):  
Chuanzhong Ye ◽  
Alicia Beeghly-Fadiel ◽  
Wei Lu ◽  
Jirong Long ◽  
Xiao Ou Shu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Gene Variants ◽  
Two Stage ◽  
Control Study

scholarly journals Tumor Necrosis Factor Alpha SNP Variant in Promoter Region G308a, cause Preeclampsia during Pregnancy in Pakistani Women, A Case Control Study

2020 ◽  
Vol 7 (4) ◽  
pp. 97-102
Author(s):  
AZIZAH ZIAUDDIN ◽  
SADIA AHMAD ◽  
ASAD IQBAL ◽  
ABDUL MAJID KHAN ◽  
SHAHID MAHMOOD
Keyword(s):  
Promoter Region ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Statistical Tool ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Risk Condition ◽  
Control Study

Preeclampsia (PE) is a very common critical condition during pregnancy. As PE is a high-risk condition during pregnancy, occurring in 25% of all pregnancies, worldwide. In women with PE there is an increase in hypertension and albuminuria. Elevated blood pressure can be life-threatening after 20th week of pregnancy. Single nucleotide variation in gene sequence can be disease causing, among these pathogenic SNPs, a variant in TNF-α, G308A is analyzed in many studies as a causative variant to cause preeclampsia. In this case control study fifty patients and fifty healthy individuals were enrolled for analysis of TNF-α promoter region SNP G308A from Jinnah hospital, Lahore, Pakistan. The genotyping of TNF-α (G308A) rs1800629 polymorphisms was performed by PCR-RFLP method. Data analysis was performed by using SNPStats, statistical tool. The mean age of all patients and controls were calculated, 24.4 ± 6.6 and 25.1 ± 5.3 years, respectively. The frequency of G308A polymorphism was more prevalent in the case group, in association with control group (p<0.001). There was a significant correlation between inflammation promoting genotypes of TNF-α and PE. It can be warily concluded that: TNF- α (G-308A) polymorphism can be reflected as a marker of predisposition to preeclampsia in our population.

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