Growth factor regulation of intracellular pH homeostasis under hypoxic conditions in isolated equine articular chondrocytes

2012 ◽  
Vol 31 (2) ◽  
pp. 197-203 ◽  
Author(s):  
Peter I. Milner ◽  
Hannah C. Smith ◽  
Rebecca Robinson ◽  
Robert J. Wilkins ◽  
John S. Gibson
Keyword(s):  
Growth Factor ◽  
Intracellular Ph ◽  
Articular Chondrocytes ◽  
Ph Homeostasis ◽  
Hypoxic Conditions ◽  
Growth Factor Regulation

scholarly journals Growth Factor Regulation of Growth Factors in Articular Chondrocytes

2009 ◽  
Vol 284 (11) ◽  
pp. 6697-6704 ◽  
Author(s):  
Shuiliang Shi ◽  
Scott Mercer ◽  
George J. Eckert ◽  
Stephen B. Trippel
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Articular Chondrocytes ◽  
Regulation Of Growth ◽  
Growth Factor Regulation

scholarly journals Role of Sox9 in Growth Factor Regulation of Articular Chondrocytes

2015 ◽  
Vol 116 (7) ◽  
pp. 1391-1400 ◽  
Author(s):  
Shuiliang Shi ◽  
Congrong Wang ◽  
Anthony J. Acton ◽  
George J. Eckert ◽  
Stephen B. Trippel
Keyword(s):  
Growth Factor ◽  
Articular Chondrocytes ◽  
Growth Factor Regulation

scholarly journals Endogenous versus exogenous growth factor regulation of articular chondrocytes

2013 ◽  
Vol 32 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Shuiliang Shi ◽  
Albert G. Chan ◽  
Scott Mercer ◽  
George J. Eckert ◽  
Stephen B. Trippel
Keyword(s):  
Growth Factor ◽  
Articular Chondrocytes ◽  
Exogenous Growth ◽  
Growth Factor Regulation

scholarly journals Growth factor regulation of the promoter for calcyclin, a growth-regulated gene.

1988 ◽  
Vol 263 (10) ◽  
pp. 4758-4763
Author(s):  
F Ghezzo ◽  
E Lauret ◽  
S Ferrari ◽  
R Baserga
Keyword(s):  
Growth Factor ◽  
Growth Factor Regulation

scholarly journals Molecular and Cellular Effects of Chemical Chaperone—TUDCA on ER-Stressed NHAC-kn Human Articular Chondrocytes Cultured in Normoxic and Hypoxic Conditions

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 878
Author(s):  
Magdalena Kusaczuk ◽  
Monika Naumowicz ◽  
Rafał Krętowski ◽  
Bartosz Cukierman ◽  
Marzanna Cechowska-Pasko
Keyword(s):  
Er Stress ◽  
Articular Chondrocytes ◽  
Potential Candidate ◽  
Chemical Chaperone ◽  
Cellular Effects ◽  
Chop Expression ◽  
Hypoxic Conditions ◽  
Stressed Cells ◽  
Apoptotic Activity ◽  
Potential Therapeutics

Osteoarthritis (OA) is considered one of the most common arthritic diseases characterized by progressive degradation and abnormal remodeling of articular cartilage. Potential therapeutics for OA aim at restoring proper chondrocyte functioning and inhibiting apoptosis. Previous studies have demonstrated that tauroursodeoxycholic acid (TUDCA) showed anti-inflammatory and anti-apoptotic activity in many models of various diseases, acting mainly via alleviation of endoplasmic reticulum (ER) stress. However, little is known about cytoprotective effects of TUDCA on chondrocyte cells. The present study was designed to evaluate potential effects of TUDCA on interleukin-1β (IL-1β) and tunicamycin (TNC)-stimulated NHAC-kn chondrocytes cultured in normoxic and hypoxic conditions. Our results showed that TUDCA alleviated ER stress in TNC-treated chondrocytes, as demonstrated by reduced CHOP expression; however, it was not effective enough to prevent apoptosis of NHAC-kn cells in either normoxia nor hypoxia. However, co-treatment with TUDCA alleviated inflammatory response induced by IL-1β, as shown by down regulation of Il-1β, Il-6, Il-8 and Cox2, and increased the expression of antioxidant enzyme Sod2. Additionally, TUDCA enhanced Col IIα expression in IL-1β- and TNC-stimulated cells, but only in normoxic conditions. Altogether, these results suggest that although TUDCA may display chondoprotective potential in ER-stressed cells, further analyses are still necessary to fully confirm its possible recommendation as potential candidate in OA therapy.

scholarly journals Growth Factor Regulation of Prostaglandin-Endoperoxide Synthase 2 (Ptgs2) Expression in Colonic Mesenchymal Stem Cells

2009 ◽  
Vol 285 (7) ◽  
pp. 5026-5039 ◽  
Author(s):  
Monica R. Walker ◽  
Sarah L. Brown ◽  
Terrence E. Riehl ◽  
William F. Stenson ◽  
Thaddeus S. Stappenbeck
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Prostaglandin Endoperoxide ◽  
Prostaglandin Endoperoxide Synthase ◽  
Growth Factor Regulation
Sign in / Sign up

Export Citation Format

Share Document