scholarly journals Selective and non-selective cyclooxygenase inhibitors delay stress fracture healing in the rat ulna

2012 ◽  
Vol 31 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Lisa J. Kidd ◽  
Nick R. Cowling ◽  
Andy C. Wu ◽  
Wendy L. Kelly ◽  
Mark R. Forwood
Keyword(s):  
Fracture Healing ◽  
Stress Fracture ◽  
Cyclooxygenase Inhibitors

Do Capactively Coupled Electric Fields Accelerate Tibial Stress Fracture Healing

2005 ◽  
Author(s):  
Andrew R. Hoffman ◽  
Belinda Beck ◽  
Gordon Matheson ◽  
Gabrielle Bergman
Keyword(s):  
Fracture Healing ◽  
Electric Fields ◽  
Stress Fracture ◽  
Tibial Stress Fracture

scholarly journals Teriparatide and stress fracture healing in young adults (RETURN – Research on Efficacy of Teriparatide Use in the Return of recruits to Normal duty): study protocol for a randomised controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alexander T. Carswell ◽  
Katharine G. Eastman ◽  
Anna Casey ◽  
Matthew Hammond ◽  
Lee Shepstone ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Stress Fracture ◽  
Standard Care ◽  
Military Training ◽  
Physical Rehabilitation ◽  
Lower Body ◽  
Link Type ◽  
Radiological Healing ◽  
Randomised Controlled ◽  
Army Recruits

Abstract Background Stress fractures are a common and potentially debilitating overuse injury to bone and occur frequently among military recruits and athletes. Recovery from a lower body stress fracture typically requires several weeks of physical rehabilitation. Teriparatide, a recombinant form of the bioactive portion of parathyroid hormone (1–34 amino acids), is used to treat osteoporosis, prevent osteoporotic fractures, and enhance fracture healing due to its net anabolic effect on bone. The study aim is to investigate the effect of teriparatide on stress fracture healing in young, otherwise healthy adults undergoing military training. Methods In a two-arm, parallel, prospective, randomised controlled, intention-to-treat trial, Army recruits (n = 136 men and women, 18–40 years) with a magnetic resonance imaging (MRI) diagnosed lower body stress fracture (pelvic girdle, sacrum, coccyx, or lower limb) will be randomised to receive either usual Army standard care, or teriparatide and usual Army standard care. Teriparatide will be self-administered by subcutaneous injections (20 μg/day) for 16 weeks, continuing to 24 weeks where a fracture remains unhealed at week 16. The primary outcome will be the improvement in radiological healing by two grades or more, or reduction to grade zero, 8 weeks after randomisation, assessed using Fredericson grading of MRI by radiologists blind to the randomisation. Secondary outcomes will be time to radiological healing, assessed by MRI at 8, 10, 12, 14, 16, 20 and 24 weeks, until healed; time to clinical healing, assessed using a clinical severity score of injury signs and symptoms; time to discharge from Army physical rehabilitation; pain, assessed by visual analogue scale; health-related quality of life, using the Short Form (36) Health Survey; and adverse events. Exploratory outcomes will include blood and urine biochemistry; bone density and morphology assessed using dual-energy X-ray absorptiometry, peripheral quantitative computed tomography (pQCT), and high-resolution pQCT; physical activity measured using accelerometers; and long-term future fracture rate. Discussion This study will evaluate whether teriparatide, in addition to standard care, is more effective for stress fracture healing than standard care alone in Army recruits who have sustained a lower body stress fracture. Trial registration ClinicalTrials.govNCT04196855. Registered on 12 December 2019.

Emerging Options for Biologic Enhancement of Stress Fracture Healing in Athletes

2020 ◽  
Vol 28 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Timothy L. Miller ◽  
Christopher C. Kaeding ◽  
Scott A. Rodeo
Keyword(s):  
Fracture Healing ◽  
Stress Fracture

scholarly journals Do Capacitively Coupled Electric Fields Accelerate Tibial Stress Fracture Healing?

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S70-S71
Author(s):  
Belinda R. Beck ◽  
Gordon Matheson ◽  
Gabrielle Bergman ◽  
Andrew Hoffman ◽  
Tracey Norling ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Electric Fields ◽  
Stress Fracture ◽  
Capacitively Coupled ◽  
Tibial Stress Fracture

Do Capacity Coupled Electric Fields Accelerate Tibial Stress Fracture Healing?

2004 ◽  
Author(s):  
Andrew Hoffman ◽  
◽  
Belinda Beck ◽  
Gordon Matheson ◽  
Gabrielle Bergman
Keyword(s):  
Fracture Healing ◽  
Electric Fields ◽  
Stress Fracture ◽  
Tibial Stress Fracture

Various Modalities to Hasten Stress Fracture Healing

2011 ◽  
pp. 859-861 ◽  
Author(s):  
Iftach Hetsroni ◽  
Gideon Mann
Keyword(s):  
Fracture Healing ◽  
Stress Fracture

Do Capacity Coupled Electric Fields Accelerate Tibial Stress Fracture Healing

2006 ◽  
Author(s):  
Andrew R. Hoffman ◽  
Belinda Beck ◽  
Gordon Matheson ◽  
Gabrielle Bergman
Keyword(s):  
Fracture Healing ◽  
Electric Fields ◽  
Stress Fracture ◽  
Tibial Stress Fracture
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