scholarly journals Mechanical loading affects the energy metabolism of intervertebral disc cells

2011 ◽  
Vol 29 (11) ◽  
pp. 1634-1641 ◽  
Author(s):  
Hanan N. Fernando ◽  
Jessica Czamanski ◽  
Tai-Yi Yuan ◽  
Weiyong Gu ◽  
Abdi Salahadin ◽  
...  
2000 ◽  
Vol 122 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Anthony E. Baer ◽  
Lori A. Setton

Cells of the intervertebral disc exhibit spatial variations in phenotype and morphology that may be related to differences in their local mechanical environments. In this study, the stresses, strains, and dilatations in and around cells of the intervertebral disc were studied with an analytical model of the cell as a mechanical inclusion embedded in a transversely isotropic matrix. In response to tensile loading of the matrix, the local mechanical environment of the cell differed among the anatomic regions of the disc and was strongly influenced by changes in both matrix anisotropy and parameters of cell geometry. The results of this study suggest that the local cellular mechanical environment may play a role in determining both cell morphology in situ and the inhomogeneous response to mechanical loading observed in cells of the disc. [S0148-0731(00)00603-8]


2013 ◽  
Vol 31 (11) ◽  
pp. 1733-1738 ◽  
Author(s):  
Chong Wang ◽  
Silvia Gonzales ◽  
Howard Levene ◽  
Weiyong Gu ◽  
Chun-Yuh Charles Huang

Author(s):  
Yongren Wu ◽  
John Glaser ◽  
Hai Yao

The intervertebral disc (IVD) is the largest cartilaginous structure in human body that contributes to flexibility and load support in the spine. To accomplish these functions, the disc has a unique architecture consisting of a centrally-located nucleus pulposus (NP) surrounded superiorly and inferiorly by cartilage endplates (CEP) and peripherally by the annulus fibrosus (AF). Disc degeneration is strongly linked to low back pain. Poor nutrient supply has been suggested as a potential mechanism for disc degeneration. Previous theoretical studies have shown that the distributions of nutrients and metabolites (e.g., oxygen, glucose, and lactate) within the IVD depended on tissue diffusivities, nutrient supply, and cellular metabolic rates [1, 2]. Based on a multiphasic mechano-electrochemical finite element model of human IVD [3], our recent theoretical study suggested that the mechanical loading has little effect on small solute transport (e.g., glucose), but significantly affects large solute transport (e.g., growth factor). The objective of this study was to further develop the multiphasic finite element model of IVD by including the cartilage endplate and considering the nutrient consumption of disc cells. Using this model, the effects of endplate and mechanical loading on solute transport in IVD were examined.


2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376587-s-0034-1376587
Author(s):  
N. Chutkan ◽  
R. Sangani ◽  
H. Zhou ◽  
S. Fulzele

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xue Yin ◽  
Aarif Motorwala ◽  
Oraya Vesvoranan ◽  
Howard B. Levene ◽  
Weiyong Gu ◽  
...  

2003 ◽  
Vol 78 (2) ◽  
pp. 109-117 ◽  
Author(s):  
He Gruber ◽  
Ja Ingram ◽  
K Leslie ◽  
Hj Norton ◽  
En Hanley Jr

2007 ◽  
Vol 7 (5) ◽  
pp. 601-608 ◽  
Author(s):  
Andrew J.L. Walsh ◽  
Conor W. O'Neill ◽  
Jeffrey C. Lotz

2009 ◽  
Vol 19 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Thorsten Guehring ◽  
Andreas Nerlich ◽  
Markus Kroeber ◽  
Wiltrud Richter ◽  
Georg W. Omlor

Sign in / Sign up

Export Citation Format

Share Document