scholarly journals Mechanical loading affects the energy metabolism of intervertebral disc cells

2011 ◽  
Vol 29 (11) ◽  
pp. 1634-1641 ◽  
Author(s):  
Hanan N. Fernando ◽  
Jessica Czamanski ◽  
Tai-Yi Yuan ◽  
Weiyong Gu ◽  
Abdi Salahadin ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Intervertebral Disc ◽  
Mechanical Loading ◽  
Disc Cells

The Micromechanical Environment of Intervertebral Disc Cells: Effect of Matrix Anisotropy and Cell Geometry Predicted by a Linear Model

2000 ◽  
Vol 122 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Anthony E. Baer ◽  
Lori A. Setton
Keyword(s):  
Intervertebral Disc ◽  
Mechanical Loading ◽  
Cell Morphology ◽  
Transversely Isotropic ◽  
Tensile Loading ◽  
Cell Geometry ◽  
Mechanical Environment ◽  
The Matrix ◽  
Disc Cells

Cells of the intervertebral disc exhibit spatial variations in phenotype and morphology that may be related to differences in their local mechanical environments. In this study, the stresses, strains, and dilatations in and around cells of the intervertebral disc were studied with an analytical model of the cell as a mechanical inclusion embedded in a transversely isotropic matrix. In response to tensile loading of the matrix, the local mechanical environment of the cell differed among the anatomic regions of the disc and was strongly influenced by changes in both matrix anisotropy and parameters of cell geometry. The results of this study suggest that the local cellular mechanical environment may play a role in determining both cell morphology in situ and the inhomogeneous response to mechanical loading observed in cells of the disc. [S0148-0731(00)00603-8]

scholarly journals Energy metabolism of intervertebral disc under mechanical loading

2013 ◽  
Vol 31 (11) ◽  
pp. 1733-1738 ◽  
Author(s):  
Chong Wang ◽  
Silvia Gonzales ◽  
Howard Levene ◽  
Weiyong Gu ◽  
Chun-Yuh Charles Huang
Keyword(s):  
Energy Metabolism ◽  
Intervertebral Disc ◽  
Mechanical Loading

Effects of Endplate and Mechanical Loading on Solute Transport in Intervertebral Disc

2008 ◽  
Author(s):  
Yongren Wu ◽  
John Glaser ◽  
Hai Yao
Keyword(s):  
Finite Element ◽  
Intervertebral Disc ◽  
Finite Element Model ◽  
Solute Transport ◽  
Mechanical Loading ◽  
Disc Degeneration ◽  
Element Model ◽  
Nutrient Supply ◽  
Cartilage Endplate ◽  
Disc Cells

The intervertebral disc (IVD) is the largest cartilaginous structure in human body that contributes to flexibility and load support in the spine. To accomplish these functions, the disc has a unique architecture consisting of a centrally-located nucleus pulposus (NP) surrounded superiorly and inferiorly by cartilage endplates (CEP) and peripherally by the annulus fibrosus (AF). Disc degeneration is strongly linked to low back pain. Poor nutrient supply has been suggested as a potential mechanism for disc degeneration. Previous theoretical studies have shown that the distributions of nutrients and metabolites (e.g., oxygen, glucose, and lactate) within the IVD depended on tissue diffusivities, nutrient supply, and cellular metabolic rates [1, 2]. Based on a multiphasic mechano-electrochemical finite element model of human IVD [3], our recent theoretical study suggested that the mechanical loading has little effect on small solute transport (e.g., glucose), but significantly affects large solute transport (e.g., growth factor). The objective of this study was to further develop the multiphasic finite element model of IVD by including the cartilage endplate and considering the nutrient consumption of disc cells. Using this model, the effects of endplate and mechanical loading on solute transport in IVD were examined.

DNA Demethylation Regulates Anabolic and Catabolic Gene Expression in Intervertebral Disc Cells

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376587-s-0034-1376587
Author(s):  
N. Chutkan ◽  
R. Sangani ◽  
H. Zhou ◽  
S. Fulzele
Keyword(s):  
Gene Expression ◽  
Intervertebral Disc ◽  
Dna Demethylation ◽  
Catabolic Gene ◽  
Disc Cells

scholarly journals Effects of Glucose Deprivation on ATP and Proteoglycan Production of Intervertebral Disc Cells under Hypoxia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xue Yin ◽  
Aarif Motorwala ◽  
Oraya Vesvoranan ◽  
Howard B. Levene ◽  
Weiyong Gu ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Glucose Deprivation ◽  
Disc Cells

Cell shape and gene expression in human intervertebral disc cells: in vitro tissue engineering studies

2003 ◽  
Vol 78 (2) ◽  
pp. 109-117 ◽  
Author(s):  
He Gruber ◽  
Ja Ingram ◽  
K Leslie ◽  
Hj Norton ◽  
En Hanley Jr
Keyword(s):  
Gene Expression ◽  
Tissue Engineering ◽  
Intervertebral Disc ◽  
Cell Shape ◽  
Engineering Studies ◽  
Disc Cells

Glucosamine HCl alters production of inflammatory mediators by rat intervertebral disc cells in vitro

2007 ◽  
Vol 7 (5) ◽  
pp. 601-608 ◽  
Author(s):  
Andrew J.L. Walsh ◽  
Conor W. O'Neill ◽  
Jeffrey C. Lotz
Keyword(s):  
Intervertebral Disc ◽  
Inflammatory Mediators ◽  
Disc Cells

scholarly journals Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study

2009 ◽  
Vol 19 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Thorsten Guehring ◽  
Andreas Nerlich ◽  
Markus Kroeber ◽  
Wiltrud Richter ◽  
Georg W. Omlor
Keyword(s):  
Animal Study ◽  
Mechanical Loading ◽  
Experimental Animal ◽  
Disc Cells ◽  
Experimental Animal Study
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