scholarly journals The role of Dkk1 in bone mass regulation: Correlating serum Dkk1 expression with bone mineral density

2010 ◽  
Vol 29 (3) ◽  
pp. 414-418 ◽  
Author(s):  
Joseph S. Butler ◽  
David W. Murray ◽  
Conor J. Hurson ◽  
Julie O'Brien ◽  
Peter P. Doran ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral ◽  
Mineral Density ◽  
Dkk1 Expression ◽  
Bone Mass Regulation

scholarly journals A COMPARATIVE CLINICAL STUDY OF PANCHTIKTA KSHEERA BASTI AND ASTHI SANDHANIYA DRAVYA SIDDH KSHEERA BASTI IN ASTHI KSHAYA (OSTEOPOROSIS)

2020 ◽  
Vol p5 (01) ◽  
pp. 2554-2562
Author(s):  
Sunita Bola ◽  
Mahesh Kumar Sharma ◽  
Gyan Prakash Sharma
Keyword(s):  
Bone Mineral Density ◽  
Clinical Study ◽  
Bone Mass ◽  
Bone Mineral ◽  
Mineral Density ◽  
Treat Ment ◽  
Bone Mineral Density Test ◽  
Comparative Clinical Study ◽  
The One

According to Ayurveda, diseases occur due to Dhatuvaishamyta & Dhatusamya maintains regularity. The Ashti Dhathu is the one consecrated with the role of Shareera Dharana among the Saptha Dhathus. As-thikshaya is the condition in which there is Kshaya of Asthi Dhatu. Asthi Kshaya may be compared to Os-teoporosis, in which there is a decrease in bone mass leading to bone brittleness and fractures. Asthi Kshaya is one of Dhatu Kshaya. Due to Dhatu Kshaya there will be Vata Prakopa hence in the treatment decreased Vata Dosha along with nourishing Asthi Dhatu essential. Basti is considered as the best Treat-ment for the Vata Dosha and Asthi Ashrita Vyadhi and is known as Ardhachikitsa in Ayurveda. Ksheera Basti nourished the Asthi Dhatu and pacified there its Asharya Vata Dosha. Aim & Objective- To assess the efficacy of Panchtikta Ksheera Basti and Asthi Sandhaniya Dravya Siddh Ksheera Basti in the man-agement of Osteoporosis. Material and Methods- Present study was undertaken on 30 patients of Osteo-porosis. Patients diagnosed Osteoporotic by Bone Mineral Density test, were randomly divided into two Groups, A and B consisting of 10 patients each. Conclusion- The study shows that the Panchtikta Ksheera Basti and Asthi Sandhaniya Dravya Siddh Ksheera Basti are very effective in the management of Osteopo-rosis.

scholarly journals A COMPARATIVE CLINICAL STUDY OF PANCHTIKTA KSHEERA BASTI AND ASTHI SANDHANIYA DRAVYA SIDDH KSHEERA BASTI IN ASTHI KSHAYA (OSTEOPOROSIS)

2020 ◽  
Vol 08 (11) ◽  
pp. 4995-5003
Author(s):  
Sunita Bola ◽  
Mahesh Kumar Sharma ◽  
Gyan Prakash Sharma
Keyword(s):  
Bone Mineral Density ◽  
Clinical Study ◽  
Bone Mass ◽  
Bone Mineral ◽  
Mineral Density ◽  
Treat Ment ◽  
Bone Mineral Density Test ◽  
Comparative Clinical Study ◽  
The One

According to Ayurveda, diseases occur due to Dhatuvaishamyta & Dhatusamya maintains regularity. The Ashti Dhathu is the one consecrated with the role of Shareera Dharana among the Saptha Dhathus. As-thikshaya is the condition in which there is Kshaya of Asthi Dhatu. Asthi Kshaya may be compared to Os-teoporosis, in which there is a decrease in bone mass leading to bone brittleness and fractures. Asthi Kshaya is one of Dhatu Kshaya. Due to Dhatu Kshaya there will be Vata Prakopa hence in the treatment decreased Vata Dosha along with nourishing Asthi Dhatu essential. Basti is considered as the best Treat-ment for the Vata Dosha and Asthi Ashrita Vyadhi and is known as Ardhachikitsa in Ayurveda. Ksheera Basti nourished the Asthi Dhatu and pacified there its Asharya Vata Dosha. Aim & Objective-To assess the efficacy of Panchtikta Ksheera Basti and Asthi Sandhaniya Dravya Siddh Ksheera Basti in the man-agement of Osteoporosis. Material and Methods- present study was undertaken on 30 patients of Osteo-porosis. Patients diagnosed Osteoporotic by Bone Mineral Density test, were randomly divided into two Groups, A and B consisting of 10 patients each. Conclusion-The study shows that the Panchtikta Ksheera Basti and Asthi Sandhaniya Dravya Siddh Ksheera Basti are very effective in the management of Osteopo-rosis.

130: Role of Calcium Intake on Bone Mineral Density in Rostate Cancer Patients Under Androgen Deprivation Therapy

2006 ◽  
Vol 175 (4S) ◽  
pp. 41-42
Author(s):  
Anna Orsola ◽  
Jacques Planas ◽  
Carlos Salvador ◽  
José M. Abascal ◽  
Enrique Trilla ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Bone Mineral ◽  
Calcium Intake ◽  
Androgen Deprivation ◽  
Mineral Density ◽  
Rostate Cancer

scholarly journals The Association between Bone Mineral Density and Periodontal Disease in Middle-Aged Adults

2021 ◽  
Vol 18 (6) ◽  
pp. 3321
Author(s):  
Hsin-Hua Chou ◽  
Sao-Lun Lu ◽  
Sen-Te Wang ◽  
Ting-Hsuan Huang ◽  
Sam Li-Sheng Chen
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mass ◽  
Periodontal Disease ◽  
Bone Mineral ◽  
Intervention Program ◽  
Past History ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Periodontal Index

The association between osteoporosis and periodontal disease (PD) has been revealed by previous studies, but there have been few studies on the association in younger adults. We enrolled a total of 7298 adults aged 40 to 44 who underwent PD screening between 2003 and 2008. Data on quantitative ultrasound for the measurement of bone mineral density (BMD) were collected for the diagnostic criteria of osteopenia and osteoporosis. The Community Periodontal Index (CPI) was measured for defining PD. A multiple logistic regression model was used to assess the effect of low bone mass on the risk of PD. Of 7298 enrollees, 31% had periodontal pockets >3 mm, 36.2% had osteopenia, and 2.1% had osteoporosis. The 39.8% of PD prevalence was high in adults with osteoporosis, followed by 33.3% in osteopenia. A negative association was found between BMD and CPI value (p < 0.0001). Low bone mass was associated with the risk of PD (adjusted OR: 1.13; 95% CI:1.02–1.26) after adjusting the confounding factors, including age, gender, education level, overweight, smoking status, past history of osteoporosis, and diabetes mellitus. An association between BMD and PD among young adults was found. An intervention program for the prevention of PD and osteoporosis could be considered starting in young adults.

The Effect of Hormonal Oral Contraception on Acquisition of Peak Bone Mineral Density of Adolescents and Young Women

2012 ◽  
Vol 25 (3) ◽  
pp. 331-340 ◽  
Author(s):  
Susan Ziglar ◽  
Tracy S. Hunter
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral ◽  
Young Women ◽  
Bone Mineralization ◽  
Critical Time ◽  
Health Concern ◽  
Mineral Density ◽  
Peak Bone Mineral Density ◽  
Bone Mass Accrual

Maximizing bone mass in youth is touted as the best strategy to offset the natural losses of aging and the menopausal transition. Not achieving maximum peak bone mineral density (BMD) is an independent risk factor for osteoporosis and thus a public health concern. Adolescence is a critical time of bone mineralization mediated by endogenous estradiol. Research has shown that the highest velocity of bone mass accrual occurs 1 year before menarche and after the first 3 years. Low-peak attainment of BMD in young women is associated with contributing factors such as diets low in calcium, eating disorders, lack of exercise, smoking, and low estrogen states. Oral contraceptives (OCs) suppress endogenous estradiol production by suppressing the hypothalamic–pituitary–ovarian axis. Thus, OCs, by replacing endogenous estradiol with ethinyl estradiol (EE), establish and maintain new hormone levels. The early initiation and the use of very low dose of EE raises the possibility that bone mass accrual at a critical time of bone mineralization in young women or adolescents may be jeopardized. This review examines the studies of BMD in adolescents and young women that use combination hormonal contraception. Some studies had inherent limitations, such as small trial, poor control of confounders, failure to exclude women with prior use of hormonal contraceptives, or prior pregnancy from control groups. The vast majority of reviewed studies showed OCs containing 20 to 30 µg of EE interfere with acquisition of peak BMD. Limited numbers of studies examine the effects of OCs containing 35 µg on adolescents and young adults. Additionally, studies are needed evaluating the progestin component of OCs as their differing androgenic properties may affect bone mineralization as well.

scholarly journals High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study

2009 ◽  
Vol 69 (01) ◽  
pp. 163-168 ◽  
Author(s):  
M C Nevitt ◽  
Y Zhang ◽  
M K Javaid ◽  
T Neogi ◽  
J R Curtis ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Joint Space Narrowing ◽  
Weight Bearing ◽  
Joint Space ◽  
Whole Body ◽  
Mineral Density ◽  
Knee Oa ◽  
Increased Risk

Objectives:Previous studies suggest that high systemic bone mineral density (BMD) is associated with incident knee osteoarthritis (OA) defined by osteophytes but not with joint space narrowing (JSN), and are inconsistent regarding BMD and progression of existing OA. The association of BMD with incident and progressive tibiofemoral OA was tested in a large prospective study of men and women aged 50–79 years with or at risk for knee OA.Methods:Baseline and 30-month weight-bearing posteroanterior and lateral knee radiographs were scored for Kellgren-Lawrence (K-L) grade, JSN and osteophytes. Incident OA was defined as the development of K-L grade ⩾2 at follow-up. All knees were classified for increases in grade of JSN and osteophytes from baseline. The association of gender-specific quartiles of baseline BMD with risk of incident and progressive OA was analysed using logistic regression, adjusting for covariates.Results:The mean (SD) age of 1754 subjects was 63.2 (7.8) years and body mass index was 29.9 (5.4) kg/m2. In knees without baseline OA, higher femoral neck and whole body BMD were associated with an increased risk of incident OA and increases in grade of JSN and osteophytes (p<0.01 for trends); adjusted odds were 2.3–2.9-fold greater in the highest compared with the lowest BMD quartiles. In knees with existing OA, progression was not significantly related to BMD.Conclusions:In knees without OA, higher systemic BMD was associated with a greater risk of the onset of JSN and K-L grade ⩾2. The role of systemic BMD in early knee OA pathogenesis warrants further investigation.

Decreased Bone Density in Adolescent Girls With Anorexia Nervosa

PEDIATRICS ◽  
1990 ◽  
Vol 86 (3) ◽  
pp. 440-447 ◽  
Author(s):  
Laura K. Bachrach ◽  
David Guido ◽  
Debra Katzman ◽  
Iris F. Litt ◽  
Robert Marcus
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Anorexia Nervosa ◽  
Bone Density ◽  
Bone Mass ◽  
Body Mass ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Control Subjects

Osteoporosis develops in women with chronic anorexia nervosa. To determine whether bone mass is reduced in younger patients as well, bone density was studied in a group of adolescent patients with anorexia nervosa. With single- and dual-photon absorptiometry, a comparison was made of bone mineral density of midradius, lumbar spine, and whole body in 18 girls (12 to 20 years of age) with anorexia nervosa and 25 healthy control subjects of comparable age. Patients had significantly lower lumbar vertebral bone density than did control subjects (0.830 ± 0.140 vs 1.054 ± 0.139 g/cm2) and significantly lower whole body bone mass (0.700 ± 0.130 vs 0.955 ± 0.130 g/cm2). Midradius bone density was not significantly reduced. Of 18 patients, 12 had bone density greater than 2 standard deviations less than normal values for age. The diagnosis of anorexia nervosa had been made less than 1 year earlier for half of these girls. Body mass index correlated significantly with bone mass in girls who were not anorexic (P &lt; .05, .005, and .0001 for lumbar, radius, and whole body, respectively). Bone mineral correlated significantly with body mass index in patients with anorexia nervosa as well. In addition, age at onset and duration of anorexia nervosa, but not calcium intake, activity level, or duration of amenorrhea correlated significantly with bone mineral density. It was concluded that important deficits of bone mass occur as a frequent and often early complication of anorexia nervosa in adolescence. Whole body is considerably more sensitive than midradius bone density as a measure of cortical bone loss in this illness. Low body mass index is an important predictor of this reduction in bone mass.

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