scholarly journals Toll-like receptors and aseptic loosening of hip endoprosthesis-a potential to respond against danger signals?

2009 ◽  
Vol 28 (2) ◽  
pp. 184-190 ◽  
Author(s):  
Tuomas Lähdeoja ◽  
Jukka Pajarinen ◽  
Vesa-Petteri Kouri ◽  
Tarvo Sillat ◽  
Jari Salo ◽  
...  
Keyword(s):  
Aseptic Loosening ◽  
Toll Like Receptors ◽  
Hip Endoprosthesis ◽  
Danger Signals

scholarly journals Revisiting Platelets and Toll-Like Receptors (TLRs): At the Interface of Vascular Immunity and Thrombosis

2020 ◽  
Vol 21 (17) ◽  
pp. 6150 ◽  
Author(s):  
Kathryn Hally ◽  
Sebastien Fauteux-Daniel ◽  
Hind Hamzeh-Cognasse ◽  
Peter Larsen ◽  
Fabrice Cognasse
Keyword(s):  
Platelet Function ◽  
Immune Modulation ◽  
Human Platelets ◽  
Toll Like Receptors ◽  
Methodological Issues ◽  
Vascular Integrity ◽  
Danger Signals ◽  
Research Questions ◽  
Molecular Patterns ◽  
Damage Associated Molecular Patterns

While platelet function has traditionally been described in the context of maintaining vascular integrity, recent evidence suggests that platelets can modulate inflammation in a much more sophisticated and nuanced manner than previously thought. Some aspects of this expanded repertoire of platelet function are mediated via expression of Toll-like receptors (TLRs). TLRs are a family of pattern recognition receptors that recognize pathogen-associated and damage-associated molecular patterns. Activation of these receptors is crucial for orchestrating and sustaining the inflammatory response to both types of danger signals. The TLR family consists of 10 known receptors, and there is at least some evidence that each of these are expressed on or within human platelets. This review presents the literature on TLR-mediated platelet activation for each of these receptors, and the existing understanding of platelet-TLR immune modulation. This review also highlights unresolved methodological issues that potentially contribute to some of the discrepancies within the literature, and we also suggest several recommendations to overcome these issues. Current understanding of TLR-mediated platelet responses in influenza, sepsis, transfusion-related injury and cardiovascular disease are discussed, and key outstanding research questions are highlighted. In summary, we provide a resource—a “researcher’s toolkit”—for undertaking further research in the field of platelet-TLR biology.

scholarly journals Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
John Evankovich ◽  
Timothy Billiar ◽  
Allan Tsung
Keyword(s):  
Tissue Injury ◽  
Ischemia Reperfusion ◽  
Innate Immune ◽  
Toll Like Receptors ◽  
Hepatic Ischemia ◽  
Danger Signals ◽  
The Family ◽  
Hepatic Ischemia Reperfusion ◽  
Molecular Patterns ◽  
Damage Associated Molecular Patterns

The family of Toll-like receptors (TLRs) function as pattern-recognition receptors (PRRs) that respond to a myriad of highly conserved ligands. These substrates include pathogen-associated molecular patterns (PAMPs) for the recognition of invading pathogens, as well as damage-associated molecular patterns (DAMPs) for the recognition of endogenous tissue injury. While the functions of TLRs are diverse, they have received much attention for their roles in ischemia/reperfusion (I/R) injury of the liver and other organs. The TLRs play central roles in sensing tissue damage and activating the innate immune system following I/R. Engagement of TLRs by endogenous DAMPs activates proinflammatory signaling pathways leading to the production of cytokines, chemokines and further release of endogenous danger signals. This paper focuses on the most recent findings regarding TLR family members in hepatic I/R injury and transplantation.

Toll like receptors 2 and 4 are upregulated during intestinal inflammation

2001 ◽  
Vol 120 (5) ◽  
pp. A182-A183
Author(s):  
M HAUSMANN ◽  
S MESTERMANN ◽  
T SPOETTI ◽  
J SCHOELMERICH ◽  
T ANDUS ◽  
...  
Keyword(s):  
Intestinal Inflammation ◽  
Toll Like Receptors

Arthroscopic Glenoid Removal for Aseptic Loosening in Total Shoulder Arthroplasty

2020 ◽  
Author(s):  
Robert L. Brochin ◽  
Ryley K. Zastrow ◽  
Akshar V. Patel ◽  
Bradford O. Parsons ◽  
Evan L. Flatow ◽  
...  
Keyword(s):  
Aseptic Loosening ◽  
Shoulder Arthroplasty ◽  
Total Shoulder Arthroplasty

Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
M Hardtke-Wolenski ◽  
K Fischer ◽  
F Noyan ◽  
J Schlue ◽  
CS Falk ◽  
...  
Keyword(s):  
T Cells ◽  
Autoimmune Hepatitis ◽  
Genetic Predisposition ◽  
Cd4 T Cells ◽  
Danger Signals
Sign in / Sign up

Export Citation Format

Share Document