scholarly journals Lytic lesions in the femoral neck: Importance of location and evaluation of a novel minimally invasive repair technique

2008 ◽  
Vol 26 (8) ◽  
pp. 1127-1132 ◽  
Author(s):  
Tadashi S. Kaneko ◽  
Harry B. Skinner ◽  
Joyce H. Keyak
Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4662-4662
Author(s):  
Akif S. Yavuz ◽  
Nilüfer Alpay ◽  
Öner Dogan ◽  
Nesimi Büyükbabani ◽  
Can Baykal ◽  
...  

Abstract Osteoporosis, osteosclerosis and lytic lesions, have been observed in patients with SM possibly reflecting different amounts of infiltrating mast cells and variation in the active substances they secrete. SM patients may be prone to pathological fractures. In a former study using dual energy X-ray absorptiometry (DXA), it was reported that SM patients with more severe disease had significantly higher bone density at the L1–L4 spine and femoral neck then those patients with less severe disease. We therefore investigated the value of quantitative ultrasound QUS of the calcaneus expressed as the stiffness index in the assessment of BMD in SM patients, as well as BMD of lumbar spine (L1–L4), femoral neck and distal radius using DXA and biochemical markers of bone turnover, plasma tryptase levels and their correlation with the clinical features. Fourteen adult patients (4 females, 10 males, median age 37, and range 23–64) with mastocytosis were included in this study. Overall, nine out of 14 patients had T scores at L1–L4 spine, femoral neck, and distal radius or as calcaneus stiffness less than −1 at least at one site reflecting osteopenia. Three out of 14 patients had T scores showing osteoporosis (T score<-2.5) (Table 1). There was a significant negative correlation between tryptase levels and distal radius T scores and a significant positive correlation between tryptase levels and disease severity as well as between disease severity and pyridinoline, a marker of osteoclastic activity. The distal radius T scores showed a negative correlation with disease severity (p<0.05 by Spearman’s test). DXA is not an appropriate technique to assess osteopenia in SM patients because of osteosclerosis, which occurs more frequently in patients with severe disease. However, this study supports the value of DXA, assessed at distal radius, for showing osteopenia in patients with mastocytosis. To assess the reliability of QUS of the calcaneus in SM patients more cases are needed. The osteoclastic marker pyridinoline is helpful in patients with severe disease activity and sclerotic bone lesions to show bone demineralization. Table 1 L1-L4 spine Femoral neck Distal radius Diagnostic category Tscore<-1 (n) Tscore<-2.5(n) Tscore<-1 (n) Tscore<-2.5(n) Tscore<-1 (n) Tscore<-2.5(n) Calcaneus stiffnessTscore<-1(n) CM: Cutaneous mastocytosis, ISM: Indolent systemic mastocytosis, SSM: Smoldering systemic mastocytosis, ASM: Aggressive systemic mastocytosis, MCL: Mast cell leukemia, ND: not done All (n=14) 6 2 1 0 9 2 7 CM (n=4) 0 0 0 0 1 0 1 ISM (n=6) 5 2 1 0 5 1 5 SSM (n=2) 1 0 0 0 2 1 1 ASM (n=1) 0 0 0 0 0 0 0 MCL (n=1) 0 0 0 0 1 0 ND Table 2 Diagnostic category Disease severity Osteocalcin (3.1–13.7 ng/ml) Bone alkaline phosphatase (Females: 11.6–29.6 U/L, males: 15–41.3 U/L) Deoxypyridinoline (Females: 6–13.5 and males: 5–11 pmol/μmol creatinine) Pyridinoline (Females: 25–63 and males: 20–52 pmol/μmol creatinine) Tryptase levels(<13.5 μg/L) Lytic lesions/ Sclerotic lesions All (n=14) - 9±7 51±40 9±3 59±43 89±71 6/3 CM (n=4) 1 8±6 37±16 6±1 19±7 5±2 0/0 ISM (n=6) 2 6±4 40±11 9±4 51±18 109±55 2/0 SSM (n=2) 3 19±12 42±10 12±0 86±3 144±38 2/1 ASM (n=1) 4 2 48 6 114 80 1/1 MCL (n=1) 5 9 185 11 161 200 1/1


2019 ◽  
Vol 27 (1) ◽  
pp. 230949901983241 ◽  
Author(s):  
Mitsuaki Noda ◽  
Masayasu Takahashi ◽  
Koji Nukuto ◽  
Masahiro Fujita ◽  
Issei Shinohara ◽  
...  

2021 ◽  
pp. 1098612X2110107
Author(s):  
Cheol-kyu Han ◽  
Jinsu Kang ◽  
Haebeom Lee ◽  
Namsoo Kim ◽  
Suyoung Heo

Objectives The aim of this study was to describe an alternative landmark for screw insertion into the body of the ilium with bilateral sacroiliac luxation in cats. Methods Seven cat cadavers with artificially induced bilateral sacroiliac luxation were used. The screw insertion point was determined using the caudal iliac crest and cranial acetabular rim. These two points make the first guideline; a second guideline ran perpendicular to the caudal iliac crest point. The screw insertion point was halfway along the second guideline across the ilium body. Surgery was performed in a minimally invasive manner using fluoroscopy. Results Postoperative radiographs and CT were performed. In the postoperative evaluation, the sacroiliac joint reduction percentage was almost 90% and there was no significant difference in pelvic canal diameter ratio before and after surgery. Screw depth/sacral width was >60% in all cadavers. On CT, the angle between the screw and sacrum wing was within the normal range of 96.24° to the left and 98.65° to the right, except in one case. Conclusions and relevance In previous studies, surgical repair was based on having an intact contralateral ilium. However, this method is not applicable to patients with bilateral sacroiliac luxation and is mostly performed using open reduction methods. The screw insertion point suggested in this study offers a potential alternative repair technique for patients with bilateral sacroiliac luxation.


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