Safety of, and biological and functional response to, a novel metallic implant for the management of focal full-thickness cartilage defects: Preliminary assessment in an animal model out to 1 year

2006 ◽  
Vol 24 (5) ◽  
pp. 1095-1108 ◽  
Author(s):  
Carl A. Kirker-Head ◽  
David C. Van Sickle ◽  
Steve W. Ek ◽  
John C. McCool
Keyword(s):  
Animal Model ◽  
Functional Response ◽  
Cartilage Defects ◽  
Full Thickness ◽  
Preliminary Assessment ◽  
Metallic Implant

scholarly journals Treatment of Full-Thickness Cartilage Defects with Pedunculated and Free Synovial Grafts: A Comparative Study in an Animal Model

2020 ◽  
Vol 54 (5) ◽  
pp. 720-725
Author(s):  
Bahtiyar Haberal ◽  
Orcun Sahin ◽  
Aysen Terzi ◽  
Ekin Kaya Simsek ◽  
Ates Mahmuti ◽  
...  
Keyword(s):  
Animal Model ◽  
Comparative Study ◽  
Cartilage Defects ◽  
Full Thickness

Treatment of full-thickness cartilage defects with pedunculated and free synovial grafts: A comparative study in an animal model

2019 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Bahtiyar Haberal ◽  
Orcun Sahin ◽  
Aysen Terzi ◽  
EkinKaya Simsek ◽  
Ates Mahmuti ◽  
...  
Keyword(s):  
Animal Model ◽  
Comparative Study ◽  
Cartilage Defects ◽  
Full Thickness

scholarly journals Allogeneic Umbilical Cord Blood–Derived Mesenchymal Stem Cell Implantation Versus Microfracture for Large, Full-Thickness Cartilage Defects in Older Patients: A Multicenter Randomized Clinical Trial and Extended 5-Year Clinical Follow-up

2021 ◽  
Vol 9 (1) ◽  
pp. 232596712097305
Author(s):  
Hong-Chul Lim ◽  
Yong-Beom Park ◽  
Chul-Won Ha ◽  
Brian J. Cole ◽  
Beom-Koo Lee ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Adverse Events ◽  
Cartilage Repair ◽  
Older Patients ◽  
Cartilage Defects ◽  
Full Thickness ◽  
Phase 3 ◽  
Randomized Controlled ◽  
Cartilage Restoration

Background: There is currently no optimal method for cartilage restoration in large, full-thickness cartilage defects in older patients. Purpose: To determine whether implantation of a composite of allogeneic umbilical cord blood–derived mesenchymal stem cells and 4% hyaluronate (UCB-MSC-HA) will result in reliable cartilage restoration in patients with large, full-thickness cartilage defects and whether any clinical improvements can be maintained up to 5 years postoperatively. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A randomized controlled phase 3 clinical trial was conducted for 48 weeks, and the participants then underwent extended 5-year observational follow-up. Enrolled were patients with large, full-thickness cartilage defects (International Cartilage Repair Society [ICRS] grade 4) in a single compartment of the knee joint, as confirmed by arthroscopy. The defect was treated either with UCB-MSC-HA implantation through mini-arthrotomy or with microfracture. The primary outcome was proportion of participants who improved by ≥1 grade on the ICRS Macroscopic Cartilage Repair Assessment (blinded evaluation) at 48-week arthroscopy. Secondary outcomes included histologic assessment; changes in pain visual analog scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and International Knee Documentation Committee (IKDC) score from baseline; and adverse events. Results: Among 114 randomized participants (mean age, 55.9 years; 67% female; body mass index, 26.2 kg/m2), 89 completed the phase 3 clinical trial and 73 were enrolled in the 5-year follow-up study. The mean defect size was 4.9 cm2 in the UCB-MSC-HA group and 4.0 cm2 in the microfracture group ( P = .051). At 48 weeks, improvement by ≥1 ICRS grade was seen in 97.7% of the UCB-MSC-HA group versus 71.7% of the microfracture group ( P = .001); the overall histologic assessment score was also superior in the UCB-MSC-HA group ( P = .036). Improvement in VAS pain, WOMAC, and IKDC scores were not significantly different between the groups at 48 weeks, however the clinical results were significantly better in the UCB-MSC-HA group at 3- to 5-year follow-up ( P < .05). There were no differences between the groups in adverse events. Conclusion: In older patients with symptomatic, large, full-thickness cartilage defects with or without osteoarthritis, UCB-MSC-HA implantation resulted in improved cartilage grade at second-look arthroscopy and provided more improvement in pain and function up to 5 years compared with microfracture. Registration: NCT01041001, NCT01626677 (ClinicalTrials.gov identifier).

Cell-free macro-porous fibrin scaffolds for in situ inductive regeneration of full-thickness cartilage defects

2016 ◽  
Vol 4 (25) ◽  
pp. 4410-4419 ◽  
Author(s):  
Yuankun Dai ◽  
Gang Liu ◽  
Lie Ma ◽  
Dongan Wang ◽  
Changyou Gao
Keyword(s):  
Growth Factors ◽  
Cartilage Regeneration ◽  
Cartilage Defects ◽  
Full Thickness ◽  
Fibrin Scaffold

Macro-porous fibrin scaffold was fabricated and used to induce cartilage regenerationin situwithout pre-loaded cells or growth factors.

Repair of Full-Thickness Cartilage Defects in Rabbit Knees With Free Periosteal Graft Preincubated With Transforming Growth Factor

Orthopedics ◽  
2003 ◽  
Vol 26 (4) ◽  
pp. 393-402
Author(s):  
Po-Ching Hseh ◽  
Surin Thanapipatsiri ◽  
Peggy C Anderson ◽  
Gwo-Jaw Wang ◽  
Gary Balian
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Cartilage Defects ◽  
Full Thickness
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