<p>This study explores the main drivers of heat wave (HW) events in central Chile using state-of-the-art reanalysis data (ERA5) and observations during the extended austral summer season (November to March) for the period 1979-2018. Frequency and intensity aspects of the HW events are considered using the total number of HW events per season and the amplitude, respectively. We first contrast ERA5 with several surface meteorological stations in central Chile to evaluate its ability to capture daily maximum temperature variability and the HW events. We then use synoptic- and large-scale fields and teleconnection patterns to address the most favorable conditions of the HW events from a climatological perspective, as well as for the extreme January 2017 HW event that swept central Chile with temperature records and wildfires. ERA5 tends to capture temperature extremes and the HW events at the inland stations; on the contrary, it has difficulties in capturing the maximum temperature variability at the coastal stations, which is plausible given the complex terrain features and confined coastal climate zone (only ~7% of all grid boxes within central Chile). The HW composite based on ERA5 reveals a mid-level trough-ridge dipole pattern exhibiting a blocking anticyclone on the surface over a large part of southwest South America. Relatively dry and warm easterly flow appears to accompany the anomalous warming in a large part of central Chile. The temporal evolution of the HW events yields a wave-like propagation pattern and enhancement of trough-ridge pattern along the South Pacific. This meridional dipole pattern is found to be largely associated with the Pacific South American pattern. In addition, the Madden-Julian Oscillation (MJO) appears to be a key component of the HW events in central Chile. In particular, while active MJO phases 2 and 7 promote sub-seasonal patterns that favor the South Pacific dipole mode, synoptic anomalies can superimpose on them and favor the formation of a migrating anticyclone over central-southern Chile and coastal lows over central Chile. Agreeing with the climatological findings, the extreme January 2017 HW analysis suggests that an eastward migratory mid-latitude trough-ridge pattern associated with the MJO phase 2 was at work. We highlight that, in addition to large- and synoptic-scale features, sub-synoptic processes such as coastal lows can have an important role in shaping the HW events and can lead to amplification of temperature extremes during the HW events.</p>