scholarly journals Characterization of persistent atrial fibrillation with non‐contact charge density mapping and relationship to voltage

2021 ◽  
Author(s):  
Justin M. S. Lee ◽  
Thomas A. Nelson ◽  
Richard H. Clayton ◽  
Nicholas F. Kelland
Keyword(s):  
Atrial Fibrillation ◽  
Charge Density ◽  
Persistent Atrial Fibrillation ◽  
Density Mapping ◽  
Contact Charge Density

scholarly journals Diverse activation patterns during persistent atrial fibrillation by noncontact charge‐density mapping of human atrium

2020 ◽  
Vol 36 (4) ◽  
pp. 692-702 ◽  
Author(s):  
Rui Shi ◽  
Zhong Chen ◽  
Charlie Butcher ◽  
Junaid AB Zaman ◽  
Vennela Boyalla ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Charge Density ◽  
Persistent Atrial Fibrillation ◽  
Human Atrium ◽  
Activation Patterns ◽  
Density Mapping

Application of recurrence plot analysis to characterise whole chamber propagation of atrial fibrillation

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
M Pope ◽  
P Kuklik ◽  
A Briosa E Gala ◽  
M Leo ◽  
J Paisey ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Charge Density ◽  
De Novo ◽  
Inverse Correlation ◽  
Right Atrial ◽  
Research Centre ◽  
Activation Patterns ◽  
Density Mapping ◽  
Distance Matrices

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Oxford Biomedical Research Centre Introduction Non-contact charge density mapping allows visualisation of whole chamber propagation during atrial fibrillation (AF). The identification of regions with repetitive or, conversely, more complex patterns of wavefront propagation may provide clues to mechanisms responsible for AF maintenance and lead to improved outcomes from catheter ablation. Our novel mapping approach based on signal recurrence plots has never been applied to whole chamber, bi-atrial recording of atrial fibrillation. Purpose To apply recurrence analysis to characterise whole chamber bi-atrial AF propagation. Methods Non-contact dipole signals from left and right atrial maps were obtained during simultaneous bi-atrial charge density mapping of AF. Signals were converted to phase and mean phase coherence calculated for the generation of recurrence distance matrices for the whole chamber and each anatomical region (6x LA and 4x RA) over the 30-second recording duration, where a value of 1 (purple, see figure panel A) represents uniform repetitive conduction, and 0 (red), irregular, non-repetitive activity. Whole chamber and regional mean recurrence values were calculated and correlated with the frequency of wavefronts of localised irregular activation patterns. Results Maps were obtained prior to ablation in 21 patients (5 paroxysmal (pAF), 16 persistent AF (persAF)) undergoing de-novo catheter ablation procedures. Whole chamber recurrence was higher in patients with pAF (0.40 ± 0.08) than persAF (0.34 ± 0.05), p < 0.0005. There was an inverse correlation between regional recurrence values and the number of localised irregular activations detected (-0.7021, p < 0.0005, figure panel B) with the lateral LA and anterior RA demonstrating the highest recurrence values in each chamber (figure panel C). Conclusion Use of recurrence distance matrices characterises global AF propagation phenotypes. Regional values are inversely correlated with the frequency of localised irregular activation patterns identified demonstrating an anatomic dependence in the level of AF propagation complexity, greatest in the anterior LA and septal RA. Comparison of strategies targeting regions with maximal vs. minimal values during catheter ablation may define an optimal approach to treatment of persistent AF. Abstract Figure. Recurrence abstract figure

scholarly journals Identification and Characterization of Sites Where Persistent Atrial Fibrillation Is Terminated by Localized Ablation

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Junaid A.B. Zaman ◽  
William H. Sauer ◽  
Mahmood I. Alhusseini ◽  
Tina Baykaner ◽  
Ryan T. Borne ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Persistent Atrial Fibrillation ◽  
Identification And Characterization

scholarly journals A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

2021 ◽  
Vol 12 ◽  
Author(s):  
S. Pagani ◽  
L. Dede' ◽  
A. Frontera ◽  
M. Salvador ◽  
L. R. Limite ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Electrophysiology ◽  
Computational Study ◽  
Pulmonary Veins ◽  
Coupled System ◽  
Density Mapping ◽  
Slow Conduction ◽  
Conduction Velocities ◽  
Ectopic Beats

In the context of cardiac electrophysiology, we propose a novel computational approach to highlight and explain the long-debated mechanisms behind atrial fibrillation (AF) and to reliably numerically predict its induction and sustainment. A key role is played, in this respect, by a new way of setting a parametrization of electrophysiological mathematical models based on conduction velocities; these latter are estimated from high-density mapping data, which provide a detailed characterization of patients' electrophysiological substrate during sinus rhythm. We integrate numerically approximated conduction velocities into a mathematical model consisting of a coupled system of partial and ordinary differential equations, formed by the monodomain equation and the Courtemanche-Ramirez-Nattel model. Our new model parametrization is then adopted to predict the formation and self-sustainment of localized reentries characterizing atrial fibrillation, by numerically simulating the onset of ectopic beats from the pulmonary veins. We investigate the paroxysmal and the persistent form of AF starting from electro-anatomical maps of two patients. The model's response to stimulation shows how substrate characteristics play a key role in inducing and sustaining these arrhythmias. Localized reentries are less frequent and less stable in case of paroxysmal AF, while they tend to anchor themselves in areas affected by severe slow conduction in case of persistent AF.

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