scholarly journals How minimally interrupted direct oral anticoagulants affect intraprocedural anticoagulation during atrial fibrillation ablation? Insights from a Japanese single‐center retrospective study

2019 ◽  
Vol 35 (5) ◽  
pp. 716-724
Author(s):  
Masahiro Mizobuchi ◽  
Atsushi Funatsu ◽  
Tomoko Kobayashi ◽  
Shigeru Nakamura
Keyword(s):  
Atrial Fibrillation ◽  
Retrospective Study ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Atrial Fibrillation Ablation ◽  
Single Center

scholarly journals Left Atrial Appendage Thrombus Prior to Atrial Fibrillation Ablation in the Era of Direct Oral Anticoagulants

2018 ◽  
Vol 82 (11) ◽  
pp. 2715-2721 ◽  
Author(s):  
Masahide Harada ◽  
Masayuki Koshikawa ◽  
Yuji Motoike ◽  
Tomohide Ichikawa ◽  
Kunihiko Sugimoto ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Atrial Fibrillation Ablation ◽  
Atrial Appendage ◽  
Left Atrial Appendage Thrombus

scholarly journals Group-Based Trajectory Modeling A Retrospective Study To Assess Adherence To Direct Oral Anticoagulants or Warfarin Among Atrial Fibrillation Patients and Comorbid Hypertension, Diabetes Mellitus, and Hyperlipidemia: A Retrospective Study.

2022 ◽  
Author(s):  
Anjana Mohan ◽  
Zahra Majd ◽  
Trang Trinh ◽  
Rutugandha Paranjpe ◽  
Susan Abughosh
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Fibrillation ◽  
Retrospective Study ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Primary Objective ◽  
Rapid Decline ◽  
Gradual Decline ◽  
Trajectory Modeling ◽  
Secondary Objective

Abstract Background Poor adherence to oral anticoagulants is a significant problem in atrial fibrillation (AF), especially among patients with comorbid hypertension (HTN), diabetes mellitus (DM), and hyperlipidemia as it increases the risk for cardiac and thromboembolic events. Group-based trajectory modeling (GBTM) has been used to depict longitudinal patterns of adherence. Aim This primary objective was to describe adherence trajectory patterns of direct oral anticoagulants (DOACs) or warfarin among AF patients with HTN, DM, and hyperlipidemia using GBTM. The secondary objective was to report the clinical outcomes and concomitant drug use among DOAC/warfarin cohort Method This retrospective study was conducted among continuously enrolled Medicare Advantage Plan from January 2016-December 2019. AF patients were included in this study if they had comorbid HTN, DM, and hyperlipidemia with at least one pharmacy claim for warfarin/DOAC prescription. Monthly adherence to DOAC/warfarin was measured using proportion of days covered (PDC) and then modeled in a logistic GBTM to describe patterns of adherence. Patient’s demographic, clinical characteristics, and concomitant use of DOACs/warfarin with CYP3A4,P-gp inhibitors were measured and compared across trajectories. Results Among 317 patients, 137 (59.62%) and 79 (24.92%) were DOAC, and warfarin users, respectively. The trajectory model for DOACs included gradual decline in adherence (GD, 40.4%), adherent (38.8%), and rapid decline (RD, 20.8%). The trajectories for warfarin adherence included gradual decline (GD, 18.9%), adherence (59.4%), and gaps in adherence (GA, 21.7%). Conclusion Adherence to oral anticoagulants is suboptimal. Interventions tailored according to past adherence trajectories may be effective in improving patient’s adherence.

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