Increased PO glycoprotein gene expression in primary and transfected rat Schwann cells after treatment with axolemma-enriched fraction

1993 ◽  
Vol 35 (1) ◽  
pp. 38-45 ◽  
Author(s):  
R. M. Knight ◽  
L. H. Fossom ◽  
T. J. Neuberger ◽  
B. L. Attema ◽  
G. Tennekoon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Schwann Cells ◽  
Glycoprotein Gene

Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function

Development ◽  
1998 ◽  
Vol 125 (18) ◽  
pp. 3709-3718 ◽  
Author(s):  
M. Knipper ◽  
C. Bandtlow ◽  
L. Gestwa ◽  
I. Kopschall ◽  
K. Rohbock ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Schwann Cells ◽  
Nerve Conduction ◽  
Time Course ◽  
Hormone Receptors ◽  
Marker Gene ◽  
Cranial Nerves ◽  
Proteolipid Protein ◽  
Viiith Nerve

All cranial nerves, as well as the VIIIth nerve which invades the cochlea, have a proximal end in which myelin is formed by Schwann cells and a distal end which is surrounded by oligodendrocytes. The question which arises in this context is whether peripheral and central parts of these nerves myelinate simultaneously or subsequently and whether the myelination of either of the parts occurs simultaneously at the onset of the cochlea function and under the control of neuronal activity. In the present paper, we examined the relative time course of the myelinogenesis of the distal part of the VIIIth nerve by analyzing the expression of peripheral protein P0, proteolipid protein and myelin basic protein. To our surprise, we observed that the expression of myelin markers in the peripheral and central part of the intradural part of the VIIIth nerve started simultaneously, from postnatal day 2 onwards, long before the onset of cochlea function. The expression rapidly achieved saturation levels on the approach to postnatal day 12, the day on which the cochlea function commenced. Because of its importance for the neuronal and morphological maturation of the cochlea during this time, an additional role of thyroid hormone in cochlear myelinogenesis was considered. Indeed, it transpires that this hormone ensures the rapid accomplishment of glial gene expression, not only in the central but also in the peripheral part of the cochlea. Furthermore, an analysis of the thyroid hormone receptors, TRaplha and TRbeta, indicates that TRbeta is necessary for myelinogenesis of the VIIIth nerve. Rapid thyroid hormone-dependent saturation of myelin marker gene expression in Schwann cells and oligodendrocytes of the VIIIth nerve may guarantee nerve conduction and synchronized impulse transmission at the onset of hearing. The thyroid hormone-dependent commencement of nerve conduction is discussed in connection with the patterning refinement of central auditory pathways and the acquisition of deafness.

Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells

2006 ◽  
Vol 11 (2) ◽  
pp. 111-118 ◽  
Author(s):  
Valerio Magnaghi ◽  
Sergio Veiga ◽  
Marinella Ballabio ◽  
Lucas C. Gonzalez ◽  
Luis M. Garcia-Segura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Schwann Cells ◽  
Myelin Proteins

Expression of a retroposon-like sequence upstream of the putative Trypanosoma brucei variant surface glycoprotein gene expression site promoter

1993 ◽  
Vol 13 (11) ◽  
pp. 7036-7044
Author(s):  
M J Lodes ◽  
B L Smiley ◽  
A W Stadnyk ◽  
J L Bennett ◽  
P J Myler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Trypanosoma Brucei ◽  
Copy Number ◽  
Surface Glycoprotein ◽  
Variant Surface Glycoprotein ◽  
Putative Promoter ◽  
Glycoprotein Gene ◽  
Active Expression ◽  
Expression Site ◽  
Total Copy Number

We have cloned the region spanning the putative promoter from two variant surface glycoprotein gene expression sites that are at each end of chromosome M4 of Trypanosoma brucei IsTat 7. Both expression sites contain a retroposon-like sequence (ESR) pseudogene whose 3' end is approximately 30 bp upstream of the putative expression site promoter. The ESRs from both expression sites share considerable sequence homology and are related to LINE-like elements, especially the T. brucei ingi retroposon. Other ESRs are located on large, but not intermediate or mini-, chromosomes in the IsTaR 1 serodeme, and the total copy number is 10 to 20, similar to that estimated for variant surface glycoprotein expression sites. No DNA rearrangements in the vicinity of the ESR and putative expression site promoter were detected following antigenic switches in the IsTaR 1 serodeme. ESR transcripts are present in bloodstream, but not procyclic, forms. Variation in transcript size and sequence between bloodstream variant antigenic types implies that only the ESR from the active expression site is transcribed. This pattern of expression reflects that of sequences downstream of the putative expression site promoter, suggesting that the region of coordinately controlled expression extends upstream of this promoter.

Pregnancy-Specific Glycoprotein Gene Expression and the Induction by 5-Bromo-2'-deoxyuridine

Biochemistry ◽  
1994 ◽  
Vol 33 (23) ◽  
pp. 7260-7266 ◽  
Author(s):  
Chi-Jiunn Pan ◽  
Margaret E. Chamberlin ◽  
Shao-Ming Wu ◽  
Wai-Yee Chan ◽  
Janice Yang Chou
Keyword(s):  
Gene Expression ◽  
Glycoprotein Gene
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