Sex and estrous‐phase dependent alterations in depression‐like behavior following mild traumatic brain injury in adolescent rats

2021 ◽  
Author(s):  
Laura L. Giacometti ◽  
Jimmy W. Huh ◽  
Ramesh Raghupathi
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Adolescent Rats

scholarly journals Sex matters: repetitive mild traumatic brain injury in adolescent rats

2017 ◽  
Vol 4 (9) ◽  
pp. 640-654 ◽  
Author(s):  
David K. Wright ◽  
Terence J. O'Brien ◽  
Sandy R. Shultz ◽  
Richelle Mychasiuk
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Adolescent Rats

A Bump on the Head or Late to Bed: Behavioral and Pathophysiological Effects of Sleep Deprivation after Repetitive Mild Traumatic Brain Injury in Adolescent Rats

2018 ◽  
Vol 35 (16) ◽  
pp. 1895-1905 ◽  
Author(s):  
Sabrina Salberg ◽  
Jennaya Christensen ◽  
Glenn R. Yamakawa ◽  
Connor Lengkeek ◽  
Haris Malik ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Sleep Deprivation ◽  
Mild Traumatic Brain Injury ◽  
Adolescent Rats

The behavioural and pathophysiological effects of the ketogenic diet on mild traumatic brain injury in adolescent rats

2019 ◽  
Vol 376 ◽  
pp. 112225 ◽  
Author(s):  
Sabrina Salberg ◽  
Himanthri Weerwardhena ◽  
Reid Collins ◽  
Raylene A. Reimer ◽  
Richelle Mychasiuk
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Ketogenic Diet ◽  
Mild Traumatic Brain Injury ◽  
Adolescent Rats

scholarly journals Examining the Effects of Anabolic–Androgenic Steroids on Repetitive Mild Traumatic Brain Injury (RmTBI) Outcomes in Adolescent Rats

2020 ◽  
Vol 10 (5) ◽  
pp. 258
Author(s):  
Jason Tabor ◽  
David. K. Wright ◽  
Jennaya Christensen ◽  
Akram Zamani ◽  
Reid Collins ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mrna Expression ◽  
Mild Traumatic Brain Injury ◽  
Stress Responses ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Adolescent Rats ◽  
Behavioural Test ◽  
Androgenic Steroids

Background: Repetitive mild traumatic brain injury (RmTBI) is increasingly common in adolescents. Anabolic–androgenic steroid (AAS) consumption among younger professional athletes is a significant risk factor for impaired neurodevelopment. Given the increased rates and overlapping symptomology of RmTBI and AAS use, we sought to investigate the behavioural and neuropathological outcomes associated with the AAS Metandienone (Met) and RmTBI on rats. Methods: Rats received either Met or placebo and were then administered RmTBIs or sham injuries, followed by a behavioural test battery. Post-mortem MRI was conducted to examine markers of brain integrity and qRT-PCR assessed mRNA expression of markers for neurodevelopment, neuroinflammation, stress responses, and repair processes. Results: Although AAS and RmTBI did not produce cumulative deficits, AAS use was associated with detrimental outcomes including changes to depression, aggression, and memory; prefrontal cortex (PFC) atrophy and amygdala (AMYG) enlargement; damaged white matter integrity in the corpus callosum; and altered mRNA expression in the PFC and AMYG. RmTBI affected general activity and contributed to PFC atrophy. Conclusions: Findings corroborate previous results indicating that RmTBI negatively impacts neurodevelopment but also demonstrates that AAS results in significant neuropathological insult to the developing brain.

scholarly journals Behavioral and pathophysiological outcomes associated with caffeine consumption and repetitive mild traumatic brain injury (RmTBI) in adolescent rats

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187218 ◽  
Author(s):  
Glenn R. Yamakawa ◽  
Connor Lengkeek ◽  
Sabrina Salberg ◽  
Simon C. Spanswick ◽  
Richelle Mychasiuk
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Caffeine Consumption ◽  
Adolescent Rats

scholarly journals Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

2018 ◽  
Vol 5 (12) ◽  
pp. 1588-1598 ◽  
Author(s):  
Ryan C. Wortman ◽  
Alicia Meconi ◽  
Katie J. Neale ◽  
Rhys D. Brady ◽  
Stuart J. McDonald ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Diffusion Mri ◽  
Adolescent Rats

scholarly journals Repeat Mild Traumatic Brain Injury in Adolescent Rats Increases Subsequent β-Amyloid Pathogenesis

2018 ◽  
Vol 35 (1) ◽  
pp. 94-104 ◽  
Author(s):  
Daya A. Grant ◽  
Rebecka Serpa ◽  
Cameron R. Moattari ◽  
Ari Brown ◽  
Tiffany Greco ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Adolescent Rats ◽  
Β Amyloid
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