Neuronal deficiency of hypoxia‐inducible factor 2α increases hypoxic‐ischemic brain injury in neonatal mice

2021 ◽  
Author(s):  
Dawei Sun ◽  
Fuxin Lu ◽  
Ann Sheldon ◽  
Xiangning Jiang ◽  
Donna M. Ferriero
Keyword(s):  
Brain Injury ◽  
Hypoxia Inducible Factor ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Hypoxic Ischemic Brain Injury

Trace Fear Conditioning Detects Hypoxic-Ischemic Brain Injury in Neonatal Mice

2011 ◽  
Vol 33 (3-4) ◽  
pp. 222-230 ◽  
Author(s):  
Katarina Järlestedt ◽  
Alison L. Atkins ◽  
Henrik Hagberg ◽  
Marcela Pekna ◽  
Carina Mallard
Keyword(s):  
Brain Injury ◽  
Fear Conditioning ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Trace Fear Conditioning ◽  
Hypoxic Ischemic Brain Injury ◽  
Trace Fear

scholarly journals An Isolation Method for Assessment of Brain Mitochondria Function in Neonatal Mice with Hypoxic-Ischemic Brain Injury

2008 ◽  
Vol 30 (5) ◽  
pp. 319-324 ◽  
Author(s):  
Casper S. Caspersen ◽  
Alexander Sosunov ◽  
Irina Utkina-Sosunova ◽  
Veniamin I. Ratner ◽  
Anatoly A. Starkov ◽  
...  
Keyword(s):  
Brain Injury ◽  
Brain Mitochondria ◽  
Ischemic Brain Injury ◽  
Isolation Method ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Hypoxic Ischemic Brain Injury

scholarly journals Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury

2021 ◽  
Vol 148 ◽  
pp. 105200
Author(s):  
Chia-Yi Kuan ◽  
Hong-Ru Chen ◽  
Ning Gao ◽  
Yi-Min Kuo ◽  
Ching-Wen Chen ◽  
...  
Keyword(s):  
Brain Injury ◽  
Hypoxia Inducible Factor ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

Temporal profiles of cerebral blood flow in neonatal mice with hypoxic–ischemic brain injury

2011 ◽  
Vol 71 ◽  
pp. e403
Author(s):  
Makiko Ohshima ◽  
Masahiro Tsuji ◽  
Yukiko Kasahara ◽  
Akihiko Taguchi ◽  
Tomoaki Ikeda
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Hypoxic Ischemic Brain Injury ◽  
Temporal Profiles

Neonatal mice lacking functional Fas death receptors are resistant to hypoxic–ischemic brain injury

2004 ◽  
Vol 17 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Ernest M. Graham ◽  
R.Ann Sheldon ◽  
Debra L. Flock ◽  
Donna M. Ferriero ◽  
Lee J. Martin ◽  
...  
Keyword(s):  
Brain Injury ◽  
Death Receptors ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Hypoxic Ischemic Brain Injury

scholarly journals Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3108
Author(s):  
Mengya Jiao ◽  
Qun Dong ◽  
Yiting Zhang ◽  
Min Lin ◽  
Wan Zhou ◽  
...  
Keyword(s):  
Brain Injury ◽  
Neuronal Damage ◽  
Neuronal Cell ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Lepidium Meyenii ◽  
Neonatal Mice ◽  
Phosphorylated Akt ◽  
Medicinal Properties ◽  
Hypoxic Ischemic Brain Injury

Maca (Lepidium meyenii) has emerged as a popular functional plant food because of its medicinal properties and nutritional value. Macamides, as the exclusively active ingredients found in maca, are a unique series of non-polar, long-chain fatty acid N-benzylamides with multiple bioactivities such as antifatigue characteristics and improving reproductive health. In this study, a new kind of macamide, N-benzyl eicosapentaenamide (NB-EPA), was identified from maca. We further explore its potential neuroprotective role in hypoxic–ischemic brain injury. Our findings indicated that treatment with biosynthesized NB-EPA significantly alleviates the size of cerebral infarction and improves neurobehavioral disorders after hypoxic–ischemic brain damage in neonatal mice. NB-EPA inhibited the apoptosis of neuronal cells after ischemic challenge. NB-EPA improved neuronal cell survival and proliferation through the activation of phosphorylated AKT signaling. Of note, the protective property of NB-EPA against ischemic neuronal damage was dependent on suppression of the p53–PUMA pathway. Taken together, these findings suggest that NB-EPA may represent a new neuroprotectant for newborns with hypoxic–ischemic encephalopathy.

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