Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials

2021 ◽  
Author(s):  
Sai Varshini Magham ◽  
Praveen Thaggikuppe krishnamurthy ◽  
Neenu Shaji ◽  
Lalithkumar Mani ◽  
Shivaramakrishnan Balasubramanian
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 2 ◽  
Selective Agonists ◽  
Insight Into

P4-311: EVALUATION OF CANNABINOID RECEPTOR 2 PET IMAGING TRACERS IN ALZHEIMER'S DISEASE BRAIN

2006 ◽  
Vol 14 (7S_Part_30) ◽  
pp. P1575-P1575
Author(s):  
Ruiqing Ni ◽  
Ahmed Haider ◽  
Adrianne Herde ◽  
Jan Klohs ◽  
Linjing Mu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pet Imaging ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 2

Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer’s Disease-Like Pathology

2018 ◽  
Vol 64 (2) ◽  
pp. 379-392 ◽  
Author(s):  
Anne-Caroline Schmöle ◽  
Ramona Lundt ◽  
Gregor Toporowski ◽  
Jan N. Hansen ◽  
Eva Beins ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cannabinoid Receptor ◽  
Disease Symptoms ◽  
Cannabinoid Receptor 2

Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model

2015 ◽  
Vol 36 (2) ◽  
pp. 710-719 ◽  
Author(s):  
Anne-Caroline Schmöle ◽  
Ramona Lundt ◽  
Svenja Ternes ◽  
Önder Albayram ◽  
Thomas Ulas ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 2

Voxel-based morphometry (VBM) analysis in Alzheimer's disease an insight into heterogeneity of cerebral atrophy

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S338-S338
Author(s):  
Akihiko Shiino ◽  
Toshiyuki Watanabe ◽  
Ichiro Akiguchi ◽  
Shigehiro Morikawa ◽  
Toshiro Inubushi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Atrophy ◽  
Voxel Based Morphometry ◽  
Insight Into

scholarly journals Continuous and Cyclic Progesterone Differentially Interact with Estradiol in the Regulation of Alzheimer-Like Pathology in Female 3×Transgenic-Alzheimer’s Disease Mice

Endocrinology ◽  
2010 ◽  
Vol 151 (6) ◽  
pp. 2713-2722 ◽  
Author(s):  
Jenna C. Carroll ◽  
Emily R. Rosario ◽  
Angela Villamagna ◽  
Christian J. Pike
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Postmenopausal Women ◽  
Transgenic Mouse Model ◽  
Dependent Behavior ◽  
Potential Efficacy ◽  
Increased Risk ◽  
Neural Interactions ◽  
Β Amyloid ◽  
Insight Into

Depletion of estrogens and progesterone at menopause has been linked to an increased risk for the development of Alzheimer’s disease (AD) in women. A currently controversial literature indicates that although treatment of postmenopausal women with hormone therapy (HT) may reduce the risk of AD, several parameters of HT may limit its potential efficacy and perhaps, even exacerbate AD risk. One such parameter is continuous vs. cyclic delivery of the progestogen component of HT. Recent experimental evidence suggests that continuous progesterone can attenuate neural actions of estradiol (E2). In the present study, we compared the effects of continuous and cyclic progesterone treatment in the presence and absence of E2 in ovariectomized 3×Tg-AD mice, a transgenic mouse model of AD. We found that ovariectomy-induced hormone depletion increases AD-like pathology in female 3×Tg-AD mice, including accumulation of β-amyloid, tau hyperphosphorylation, and impaired hippocampal-dependent behavior. E2 treatment alone prevents the increases in pathology. Continuous progesterone did not affect β-amyloid levels when delivered alone but blocked the Aβ-lowering action of E2. In contrast, cyclic progesterone significantly reduced β-amyloid levels by itself and enhanced rather than inhibited the E2 effects. These results provide new insight into the neural interactions between E2 and progesterone that may prove valuable in optimizing HT regimens in postmenopausal women.

scholarly journals Specks of insight into Alzheimer’s disease

Nature ◽  
2017 ◽  
Vol 552 (7685) ◽  
pp. 342-343 ◽  
Author(s):  
Richard M. Ransohoff
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Insight Into

Mechanistic insight into the role of metformin in Alzheimer's disease

Life Sciences ◽  
2022 ◽  
pp. 120299
Author(s):  
Mehdi Sanati ◽  
Samaneh Aminyavari ◽  
Amir R. Afshari ◽  
Amirhossein Sahebkar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mechanistic Insight ◽  
Insight Into
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