Neonatal administration of erythropoietin attenuates cognitive deficits in adult rats following placental insufficiency

2021 ◽  
Author(s):  
Shenandoah Robinson ◽  
Jesse L. Winer ◽  
Yuma Kitase ◽  
Jonathan L. Brigman ◽  
Lauren L. Jantzie
Keyword(s):  
Cognitive Deficits ◽  
Placental Insufficiency ◽  
Adult Rats ◽  
Neonatal Administration

Short-Term Exposure to Enriched Environment in Adult Rats Restores MK-801-Induced Cognitive Deficits and GABAergic Interneuron Immunoreactivity Loss

2017 ◽  
Vol 55 (1) ◽  
pp. 26-41 ◽  
Author(s):  
Ane Murueta-Goyena ◽  
Naiara Ortuzar ◽  
Pascual Ángel Gargiulo ◽  
José Vicente Lafuente ◽  
Harkaitz Bengoetxea
Keyword(s):  
Cognitive Deficits ◽  
Enriched Environment ◽  
Gabaergic Interneuron ◽  
Short Term ◽  
Adult Rats ◽  
Mk 801 ◽  
Short Term Exposure

ULTRAMORPHOMETRIC STUDIES OF THE ADRENAL CORTEX OF ADULT RATS AFTER NEONATAL ADMINISTRATION OF SEX STEROIDS

1976 ◽  
Vol 81 (2) ◽  
pp. 537-547 ◽  
Author(s):  
E. Mäusle ◽  
G. Fickinger
Keyword(s):  
Sex Steroids ◽  
Smooth Endoplasmic Reticulum ◽  
Zona Fasciculata ◽  
Sprague Dawley ◽  
Adult Rats ◽  
Sprague Dawley Rats ◽  
Neonatal Administration ◽  
The Individual ◽  
Increased Activity ◽  
Functional Reaction

ABSTRACT The outer zona fasciculata of 28 Sprague-Dawley rats, 8 weeks old, was studied by means of ultramorphometry. Four males and 4 females each received 1250 μg of testosterone proprionate (TP) or 300 μg oestradiol benzoate (OeB) on the second day of life. Four males and 4 females in oestrus or dioestrus served as controls. The controls showed both sex and cyclic differences: in comparison to the males, females displayed a finely dispersed lipoid pattern; enlargement of the nucleus and an increase in the amount of smooth endoplasmic reticulum (SER) indicated an increased stimulation of the cortex during oestrus. Neonatal administration of TP in females causes a distinct enlargement of cells with an increase in the volumes of nucleus, mitochondria, liposomes, SER and liposomes. The mitochondria and liposomes show a small-dispersed pattern of distribution. All these function-specific morphometric parameters point to an increased activity of the individual cell. The changes are less pronounced after OeB than after TP. In the male, neonatal administration of sex steroids results in an alteration of the sizes of the mitochondria and liposomes. The liposomes are distributed finely dispersed. At the same time there is an increase in the lipoid content. According to these parameters, fasciculata cells fulfil the morphological conditions that are a prerequisite for an elevated functional reaction. This change is more marked following OeB than TP. Sex dimorphism is preserved following neonatal application of sex steroids since the alterations are much more pronounced in females than in males.

scholarly journals Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats

2002 ◽  
Vol 60 (4) ◽  
pp. 928-931 ◽  
Author(s):  
Cristiano Mendes-da-Silva ◽  
Sandra Lopes de Souza ◽  
Jairza Maria Barreto-Medeiros ◽  
Sebastião Rogério de Freitas-Silva ◽  
Daniela Eugênia Costa Antunes ◽  
...  
Keyword(s):  
Forced Swim Test ◽  
Experimental Models ◽  
Control Group ◽  
Adult Rats ◽  
Depressive Behavior ◽  
Swim Test ◽  
Serotonergic Activity ◽  
Forced Swim ◽  
Neonatal Administration ◽  
The Brain

Serotonin plays a role at the pathophysiology of depression in humans and in experimental models. The present study investigated the depressive behavior and the weigh evolution in adult rats (60 days) treated from the 1st to the 21st postnatal day with fluoxetine, a selective serotonin reuptake inhibitor (10 mg/kg, sc, daily). The depressive behavior was induced by the forced swim test (FST). The animals were submitted to two sessions of FST: 1st session for 15 min and the 2nd session 24h later, for 5 min. During the 2nd session the Latency of the Attempt of Escape (LAE) and Behavioral Immobility (BI) were appraised. The Fluoxetine group when compared to the Control group, showed an increase in LAE and a decrease in BI. The neonatal administration of fluoxetine reduced the depressive behavior in adult rats, possibly by increase in the brain serotonergic activity. This alteration can be associated to process of neuroadaptation.

Neonatal administration of N-acetyl-l-aspartyl-l-glutamate induces early neurodegeneration in hippocampus and alters behaviour in young adult rats

2006 ◽  
Vol 48 (6-7) ◽  
pp. 515-522 ◽  
Author(s):  
Věra Bubeníková-Valešová ◽  
Vladimir J. Balcar ◽  
Hana Tejkalová ◽  
Miloš Langmeier ◽  
František Št’astný
Keyword(s):  
Young Adult ◽  
Adult Rats ◽  
Neonatal Administration

scholarly journals Early-Delayed, Radiation-Induced Cognitive Deficits in Adult Rats are Heterogeneous and Age-Dependent

2014 ◽  
Vol 182 (1) ◽  
pp. 60 ◽  
Author(s):  
M. E. Forbes ◽  
M. Paitsel ◽  
J. D. Bourland ◽  
D. R. Riddle
Keyword(s):  
Cognitive Deficits ◽  
Adult Rats ◽  
Age Dependent ◽  
Radiation Induced

scholarly journals A single neonatal administration of soybean oil and/or tamoxifen affects permanently the testis histomorphology in adult rats.

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Alicia González González ◽  
Everardo González Padilla ◽  
Francisco Fierro Fierro ◽  
María de Lourdes Juárez Mosqueda ◽  
Juan José Pérez Rivero ◽  
...  
Keyword(s):  
Soybean Oil ◽  
Adult Rats ◽  
Neonatal Administration

scholarly journals Adolescent Rats Find Repeated Δ9-THC Less Aversive Than Adult Rats but Display Greater Residual Cognitive Deficits and Changes in Hippocampal Protein Expression Following Exposure

2007 ◽  
Vol 33 (5) ◽  
pp. 1113-1126 ◽  
Author(s):  
Heidi R Quinn ◽  
Izuru Matsumoto ◽  
Paul D Callaghan ◽  
Leonora E Long ◽  
Jonathon C Arnold ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cognitive Deficits ◽  
Adult Rats ◽  
Adolescent Rats
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