Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders

2021 ◽  
Author(s):  
Cynthia J. M. Kane ◽  
James C. Douglas ◽  
Tonya Rafferty ◽  
Jennifer W. Johnson ◽  
Victoria M. Niedzwiedz‐Massey ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fetal Alcohol Spectrum Disorders ◽  
Fetal Alcohol ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

Maternal Oral Intake Mouse Model for Fetal Alcohol Spectrum Disorders: Ocular Defects as a Measure of Effect

2006 ◽  
Vol 30 (10) ◽  
pp. 1791-1798 ◽  
Author(s):  
Scott E. Parnell ◽  
Deborah B. Dehart ◽  
Tiffany A. Wills ◽  
Shao-yu Chen ◽  
Clyde W. Hodge ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fetal Alcohol Spectrum Disorders ◽  
Oral Intake ◽  
Fetal Alcohol ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

Ethanol Effects on Cerebellar Myelination in a Postnatal Mouse Model of Fetal Alcohol Spectrum Disorders

Alcohol ◽  
2021 ◽  
Author(s):  
Victoria M. Niedzwiedz-Massey ◽  
James C. Douglas ◽  
Tonya Rafferty ◽  
Cynthia J.M. Kane ◽  
Paul D. Drew
Keyword(s):  
Mouse Model ◽  
Fetal Alcohol Spectrum Disorders ◽  
Fetal Alcohol ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

scholarly journals Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders

2021 ◽  
pp. 107015
Author(s):  
Victoria M. Niedzwiedz-Massey ◽  
James C. Douglas ◽  
Tonya Rafferty ◽  
Patricia A. Wight ◽  
Cynthia J.M. Kane ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fetal Alcohol Spectrum Disorders ◽  
Fetal Alcohol ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

scholarly journals Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders

2020 ◽  
Vol 23 (4) ◽  
pp. 533-543 ◽  
Author(s):  
Shahid Mohammad ◽  
Stephen J. Page ◽  
Li Wang ◽  
Seiji Ishii ◽  
Peijun Li ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fetal Alcohol Spectrum Disorders ◽  
Fetal Alcohol ◽  
Learning Deficits ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

Coordinated Tcf7l2 regulation in a mouse model implicates Wnt signaling in fetal alcohol spectrum disorders

2019 ◽  
Vol 97 (4) ◽  
pp. 375-379 ◽  
Author(s):  
Eric Chater-Diehl ◽  
Dustin Sokolowski ◽  
Bonnie Alberry ◽  
Shiva M. Singh
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Mouse Model ◽  
Wnt Signaling ◽  
Histone Modifications ◽  
Fetal Alcohol Spectrum Disorders ◽  
Alcohol Exposure ◽  
Fetal Alcohol ◽  
Spectrum Disorders ◽  
Fetal Alcohol Spectrum

Mouse models of fetal alcohol spectrum disorders (FASD) have repeatedly identified genes with long-term changes in expression, DNA methylation, noncoding RNA, and histone modifications in response to neurodevelopmental alcohol exposure. Articulation of FASD is achieved via alcohol’s effect on gene expression, likely involving epigenetic regulation. The list of genes affected is large and heterogeneous, depending on experimental protocol. We present reanalysis and synthesis of results highlighting the Wnt transcription factor 7 like 2 (Tcf7l2) gene as uniquely compatible with hippocampal DNA methylation, histone modifications, and gene expression changes in a coordinated response to neurodevelopmental alcohol exposure. We data-mined the literature for Tcf7l2 alterations in response to prenatal alcohol exposure. Four studies identified changes in brain Tcf7l2 expression in different FASD models. Further, we performed an in silico TCF7L2 binding site analysis for FASD mouse model data sets. Seven of these published gene lists were significantly enriched for TCF7L2 binding, indicating potential functional relationships. Finally, TCF7L2 is involved in regulation of hundreds of genes, with a role in brain development, myelination, and neuronal function. Tcf7l2 may be involved in neurological defects associated with alcohol exposure via dysregulation of many genes through Wnt signaling. Further functional work is warranted to validate this model for FASD.

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