scholarly journals Age‐dependent effects of dopamine receptor inactivation on cocaine‐induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity

2019 ◽  
Author(s):  
Cynthia A. Crawford ◽  
Angie Teran ◽  
Goretti I. Ramirez ◽  
Caitlin G. Katz ◽  
Alena Mohd‐Yusof ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
D2 Receptor ◽  
Male Rats ◽  
Receptor Supersensitivity ◽  
Age Dependent ◽  
Receptor Inactivation

scholarly journals Behavioral effects of dopamine receptor inactivation during the adolescent period: age-dependent changes in dorsal striatal D2High receptors

2013 ◽  
Vol 231 (8) ◽  
pp. 1637-1647 ◽  
Author(s):  
Sanders A. McDougall ◽  
Joseph M. Valentine ◽  
Ashley E. Gonzalez ◽  
Danielle E. Humphrey ◽  
Crystal B. Widarma ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Behavioral Effects ◽  
Age Dependent ◽  
Receptor Inactivation ◽  
Adolescent Period

scholarly journals Behavioral effects of dopamine receptor inactivation in the caudate-putamen of preweanling rats: role of the D2 receptor

2013 ◽  
Vol 231 (4) ◽  
pp. 651-662 ◽  
Author(s):  
Taleen Der-Ghazarian ◽  
Crystal B. Widarma ◽  
Arnold Gutierrez ◽  
Leslie R. Amodeo ◽  
Joseph M. Valentine ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
D2 Receptor ◽  
Behavioral Effects ◽  
Caudate Putamen ◽  
Receptor Inactivation

Inhibition of Muscimol on Morphine-Induced Hyperactivity, Reverse Tolerance and Postsynaptic Dopamine Receptor Supersensitivity

Pharmacology ◽  
2002 ◽  
Vol 65 (4) ◽  
pp. 204-209 ◽  
Author(s):  
In-Seup Yoon ◽  
Hack-Seang Kim ◽  
Jin-Tae Hong ◽  
Myung-Koo Lee ◽  
Ki-Wan Oh
Keyword(s):  
Dopamine Receptor ◽  
Receptor Supersensitivity ◽  
Dopamine Receptor Supersensitivity ◽  
Reverse Tolerance

Spermatotoxic effects of carbaryl in rats

1996 ◽  
Vol 15 (9) ◽  
pp. 736-738 ◽  
Author(s):  
N. Pant ◽  
R. Shankar ◽  
SP Srivastava
Keyword(s):  
Sperm Motility ◽  
Sperm Count ◽  
Young Male ◽  
Male Rats ◽  
Epididymal Sperm ◽  
Abnormal Morphology ◽  
Age Dependent ◽  
Effect Level

The spermatotoxic effect of carbaryl in adult and young male rats has been examined. Carbaryl 50 and 100 mg/kg b.wt. Male fed 5 d/week for 60 days, caused dose and age- dependent decline in epididymal sperm count and sperm motility, an increase in sperm with abnormal morphology. The dose of 25 mg/kg/d was a 'No observed effect level' for the indices studied. Young animals in comparison to adults exhibited pronounced spermatotoxic effects.

scholarly journals Haloperidol ameliorates androgen-induced behavioral deficits in developing male rats

2018 ◽  
Vol 237 (2) ◽  
pp. 193-205 ◽  
Author(s):  
Chunxiao Qi ◽  
Xiaoming Ji ◽  
Guoliang Zhang ◽  
Yunxiao Kang ◽  
Yuanxiang Huang ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Motor Behavior ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Neuropsychiatric Disorders ◽  
Male Rats ◽  
Neural Basis ◽  
Childhood Onset ◽  
Early Postnatal Development ◽  
Androgen Exposure

The purpose of present study was to infer the potential effects of testosterone increase in some male-based childhood-onset neuropsychiatric disorders, such as Tourette syndrome. Thus, the influence of early postnatal androgen exposure upon the neurobehaviors and its possible neural basis were investigated in the study. Male pup rats received consecutive 14-day testosterone propionate (TP) subcutaneous injection from postnatal day (PND) 7. The TP treatment produced the hyperactive motor behavior and grooming behavior as well as the increased levels of dopamine, tyrosine hydroxylase and dopamine transporter in the mesodopaminergic system and the elevated levels of serotonin in the nucleus accumbens, without affecting the levels of glutamate, γ-aminobutyric acid, norepinephrine and histamine in the caudate putamen and nucleus accumbens of PND21 and PND49 rats. Dopamine D2 receptor antagonist haloperidol was administered to the early postnatal TP-exposed PND21 and PND49 male rats 30 min prior to open field test. Haloperidol significantly ameliorated the motor behavioral and grooming behavioral defects induced by early postnatal TP exposure. The results demonstrated that early postnatal androgen exposure significantly disturbed the brain activity of developing male rats via enhancing the mesodopaminergic activity. It was suggested that abnormal increments of testosterone levels during the early postnatal development might be a potential risk factor for the incidence of some male-based childhood-onset neuropsychiatric disorders by affecting the mesodopaminergic system.

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