scholarly journals Relationship between neural crest cell specification and rare ocular diseases

2018 ◽  
Vol 97 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Monica Akula ◽  
Jeong Won Park ◽  
Judith A. West-Mays
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Ocular Diseases ◽  
Cell Specification ◽  
Crest Cell

Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body

2021 ◽  
Author(s):  
Manuel Rocha ◽  
Elaine Kushkowski ◽  
Ruby Schnirman ◽  
Clare Booth ◽  
Noor Singh ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Specification ◽  
Crest Cell

scholarly journals WNT responsive SUMOylation of ZIC5 exerts multiple effects on transcription to promote murine neural crest cell development

2020 ◽  
Author(s):  
Radiya G. Ali ◽  
Helen M. Bellchambers ◽  
Nicholas Warr ◽  
Jehangir N. Ahmed ◽  
Kristen S. Barratt ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Specification ◽  
Dna Binding Sites ◽  
Repressor Complex ◽  
Neural Plate Border ◽  
Broad Domain ◽  
And Shifts ◽  
Crest Cell

AbstractZinc finger of the cerebellum (Zic) proteins act as classical transcription factors to promote transcription of the Foxd3 gene during neural crest cell specification. Additionally, they can act as co-factors that bind TCF molecules to repress WNT/β-catenin dependent transcription without contacting DNA. Here, we show ZIC activity at the neural plate border is influenced by WNT-dependent SUMOylation. In a high WNT environment, a lysine within the highly conserved ZF-NC domain of ZIC5 is SUMOylated, which decreases formation of the TCF/ZIC co-repressor complex and shifts the balance towards transcription factor function. The modification is critical in vivo, as a ZIC5 SUMO-incompetent mouse strain exhibits neural crest specification defects. This work reveals the function of the ZIC ZF-NC domain, provides in vivo validation of target protein SUMOylation, and demonstrates that WNT/β-catenin signalling directs transcription at non-TCF DNA binding sites. Furthermore, it can explain how WNT signals convert a broad domain of Zic ectodermal expression into a restricted domain of neural crest cell specification.

scholarly journals Hmga2 is required for neural crest cell specification in Xenopus laevis

2016 ◽  
Vol 411 (1) ◽  
pp. 25-37 ◽  
Author(s):  
Simone Macrì ◽  
Luca Simula ◽  
Ilenia Pellarin ◽  
Silvia Pegoraro ◽  
Marco Onorati ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Specification ◽  
Crest Cell

scholarly journals WNT responsive SUMOylation of ZIC5 promotes murine neural crest cell development via multiple effects on transcription

2021 ◽  
Author(s):  
Radiya G. Ali ◽  
Helen M. Bellchambers ◽  
Nicholas Warr ◽  
Jehangir N. Ahmed ◽  
Kristen S. Barratt ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Specification ◽  
Dna Binding Sites ◽  
Repressor Complex ◽  
Neural Plate Border ◽  
Broad Domain ◽  
And Shifts ◽  
Crest Cell

Zinc finger of the cerebellum (Zic) proteins act as classical transcription factors to promote transcription of the Foxd3 gene during neural crest cell specification. Additionally, they can act as co-factors that bind TCF molecules to repress WNT/β-catenin-dependent transcription without contacting DNA. Here, we show ZIC activity at the neural plate border is influenced by WNT-dependent SUMOylation. In a high WNT environment, a lysine within the highly conserved ZF-NC domain of ZIC5 is SUMOylated, which decreases formation of the TCF/ZIC co-repressor complex and shifts the balance towards transcription factor function. The modification is critical in vivo, as a ZIC5 SUMO-incompetent mouse strain exhibits neural crest specification defects. This work reveals the function of the ZIC ZF-NC domain, provides in vivo validation of target protein SUMOylation, and demonstrates that WNT/β-catenin signaling directs transcription at non-TCF DNA binding sites. Furthermore, it can explain how WNT signals convert a broad domain of Zic ectodermal expression into a restricted domain of neural crest cell specification.

scholarly journals Proliferation dynamics associated with cranial neural crest cell migration

2011 ◽  
Vol 356 (1) ◽  
pp. 197
Author(s):  
Dennis A. Ridenour ◽  
Rebecca McLennan ◽  
Jessica M. Teddy ◽  
Katherine W. Prather ◽  
Craig L. Semerad ◽  
...  
Keyword(s):  
Cell Migration ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cell ◽  
Neural Crest Cell Migration ◽  
Crest Cell
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