scholarly journals Bioluminescence‐driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model

2018 ◽  
Vol 98 (3) ◽  
pp. 458-468 ◽  
Author(s):  
Jessica R. Zenchak ◽  
Brandon Palmateer ◽  
Nicolai Dorka ◽  
Tariq M. Brown ◽  
Lina‐Marie Wagner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Motor Deficits ◽  
Neural Precursor

Transplantation of expanded neural precursor cells from the developing pig ventral mesencephalon in a rat model of Parkinson's disease

2003 ◽  
Vol 151 (2) ◽  
pp. 204-217 ◽  
Author(s):  
Richard J. E. Armstrong ◽  
Pamela Tyers ◽  
Meena Jain ◽  
Andrew Richards ◽  
Stephen B. Dunnett ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Ventral Mesencephalon

scholarly journals Dual Effects of Human Placenta-Derived Neural Cells on Neuroprotection and the Inhibition of Neuroinflammation in a Rodent Model of Parkinson’s Disease

2018 ◽  
Vol 27 (5) ◽  
pp. 814-830 ◽  
Author(s):  
Han Wool Kim ◽  
Hyun-Seob Lee ◽  
Jun Mo Kang ◽  
Sang-Hun Bae ◽  
Chul Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Human Placenta ◽  
Precursor Cells ◽  
Rodent Model ◽  
Neural Precursor Cells ◽  
Substantia Nigra Pars Compacta ◽  
Neural Precursor ◽  
Age Related ◽  
Therapeutic Mechanisms

Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease in the elderly and the patients suffer from uncontrolled movement disorders due to loss of dopaminergic (DA) neurons on substantia nigra pars compacta (SNpc). We previously reported that transplantation of human fetal midbrain-derived neural precursor cells restored the functional deficits of a 6-hydroxy dopamine (6-OHDA)-treated rodent model of PD but its low viability and ethical issues still remain to be solved. Albeit immune privilege and neural differentiation potentials suggest mesenchymal stem cells (MSCs) from various tissues including human placenta MSCs (hpMSCs) for an alternative source, our understanding of their therapeutic mechanisms is still limited. To expand our knowledge on the MSC-mediated PD treatment, we here investigated the therapeutic mechanism of hpMSCs and hpMSC-derived neural phenotype cells (hpNPCs) using a PD rat model. Whereas both hpMSCs and hpNPCs protected DA neurons in the SNpc at comparable levels, the hpNPC transplantation into 6-OHDA treated rats exhibited longer lasting recovery in motor deficits than either the saline or the hpMSC treated rats. The injected hpNPCs induced delta-like ligand (DLL)1 and neurotrophic factors, and influenced environments prone to neuroprotection. Compared with hpMSCs, co-cultured hpNPCs more efficiently protected primary neural precursor cells from midbrain against 6-OHDA as well as induced their differentiation into DA neurons. Further experiments with conditioned media from hpNPCs revealed that the secreted factors from hpNPCs modulated immune responses and neural protection. Taken together, both DLL1-mediated contact signals and paracrine factors play critical roles in hpNPC-mediated improvement. First showing here that hpMSCs and their neural derivative hpNPCs were able to restore the PD-associated deficits via dual mechanisms, neuroprotection and immunosuppression, this study expanded our knowledge of therapeutic mechanisms in PD and other age-related diseases.

The Potential for Circuit Reconstruction by Expanded Neural Precursor Cells Explored through Porcine Xenografts in a Rat Model of Parkinson's Disease

2002 ◽  
Vol 175 (1) ◽  
pp. 98-111 ◽  
Author(s):  
Richard J.E. Armstrong ◽  
Carrie B. Hurelbrink ◽  
Pam Tyers ◽  
Emma L. Ratcliffe ◽  
Andrew Richards ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

scholarly journals Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation

2019 ◽  
Vol 41 ◽  
pp. 101617 ◽  
Author(s):  
Dominique Leitner ◽  
Mahesh Ramamoorthy ◽  
Marion Dejosez ◽  
Thomas P. Zwaka
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Motor Deficits
Sign in / Sign up

Export Citation Format

Share Document