scholarly journals An optimized dosing regimen of cimaglermin (neuregulin 1β3, glial growth factor 2) enhances molecular markers of neuroplasticity and functional recovery after permanent ischemic stroke in rats

2015 ◽  
Vol 94 (3) ◽  
pp. 253-265 ◽  
Author(s):  
Jennifer F. Iaci ◽  
Tom J. Parry ◽  
Zhihong Huang ◽  
Elias Pavlopoulos ◽  
Seth P. Finklestein ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Molecular Markers ◽  
Growth Factor ◽  
Functional Recovery ◽  
Dosing Regimen ◽  
Glial Growth Factor

Glial growth factor 2 promotes functional recovery with treatment initiated up to 7 days after permanent focal ischemic stroke

2010 ◽  
Vol 59 (7-8) ◽  
pp. 640-649 ◽  
Author(s):  
Jennifer F. Iaci ◽  
Anindita Ganguly ◽  
Seth P. Finklestein ◽  
Tom J. Parry ◽  
JingMei Ren ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Functional Recovery ◽  
Glial Growth Factor

Recombinant human glial growth factor 2 (rhGGF 2) improves functional recovery of crushed peripheral nerve (a double-blind study)

1998 ◽  
Vol 33 (4) ◽  
pp. 341-351 ◽  
Author(s):  
Long-En Chen ◽  
Kang Liu ◽  
Anthony V. Seaber ◽  
Subbarao Katragadda ◽  
Cassandra Kirk ◽  
...  
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Functional Recovery ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Glial Growth Factor

scholarly journals Association Between Levels of Serum Insulin-like Growth Factor I and Functional Recovery, Mortality, and Recurrent Stroke at a 7-year Follow-up

2019 ◽  
Vol 128 (05) ◽  
pp. 303-310 ◽  
Author(s):  
N. David Åberg ◽  
Daniel Åberg ◽  
Cecilia Lagging ◽  
Lukas Holmegaard ◽  
Petra Redfors ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Functional Recovery ◽  
Recurrent Stroke ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Post Stroke ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Abstract Background The association of serum insulin-like growth factor I (s-IGF-I) with favorable outcome after ischemic stroke (IS) beyond 2 years is unknown. We investigated whether the levels of s-IGF-I 3 months post-stroke were associated with functional recovery up to 7 years after IS, considering also mortality and recurrent strokes. Methods Patients (N=324; 65% males; mean age, 55 years) with s-IGF-I levels assessed 3 months after the index IS were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). The modified Rankin Scale (mRS) was used to evaluate outcomes at 3 months, 2 and 7 years after IS, and recovery was defined as an improvement, no change, or deterioration in the shifts of mRS score. Baseline stroke severity was determined using the National Institutes of Health Stroke Scale (NIHSS). Results The mRS score distributions were better in the above-median s-IGF-I group (>146.7 ng/ml). The s-IGF-I level was not associated with recurrent stroke (N=79) or death (N=44), although it correlated with recovery (r=0.12, P=0.035). In the regression analysis, s-IGF-I associated with recovery between 3 months and 7 years (but not between 2 and 7 years). The associations did not withstand adjustment for age and sex. For comparison, the corresponding associations between 3 months and 2 years withstood all adjustments. Conclusion The association for s-IGF-I with long-term post-stroke recovery persists after 7 years, which is also reflected in the mRS score distributions at all time-points. The effects are however modest, and not driven by mortality or recurrent stroke.

Insulin Growth Factor-I Promotes Functional Recovery After a Focal Lesion in the Dentate Gyrus

2012 ◽  
Vol 11 (7) ◽  
pp. 818-828 ◽  
Author(s):  
Adhemar Liquitaya-Montiel ◽  
Andrea Aguilar-Arredondo ◽  
Clorinda Arias ◽  
Angelica Zepeda
Keyword(s):  
Growth Factor ◽  
Dentate Gyrus ◽  
Functional Recovery ◽  
Focal Lesion ◽  
Insulin Growth Factor ◽  
Factor I ◽  
Growth Factor I

Role of S100β Glial Protein as a Serological Marker for Analysis of Acute Ischemic Stroke

2021 ◽  
pp. 251660852110112
Author(s):  
Kiran Buddharaju ◽  
Mahendra Javali ◽  
Anish Mehta ◽  
R Srinivasa ◽  
Purushottam Acharya
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Functional Recovery ◽  
Protein Level ◽  
Serological Marker ◽  
Protein Levels ◽  
S100β Protein ◽  
Asymptomatic Volunteers ◽  
Scale Scores

Background: Stroke is a major cause of neurological disability, which can be often predicted with serological markers. Glial-derived S100β protein is a potential biomarker for cerebral ischemia and may be helpful in predicting the severity, outcome, and recovery of stroke. Aim: This study aimed to study the role of S100β glial protein as a serological marker in predicting the severity of acute ischemic stroke (AIS), outcome, and functional recovery after 1 month. Methods: A hospital-based prospective case control study included 43 consecutive patients, >18 years old, who were admitted with acute middle cerebral artery (MCA) territory infarcts within 72 h of onset of neurological deficits. Control group comprised of 43 age-matched asymptomatic volunteers. Independent t-test and chi square test were used to compare the means and evaluate the association between protein level and various parameters. P ≤ .05 was statistically significant. Results: S100β protein level in AIS patients was significantly higher compared to controls ( P < .05). Elevated serum S100β protein level was found to be associated with larger infarct volumes, higher National Institute Health Stroke Scale scores, and higher modified Rankin Scale scores at admission ( P < .05). Patients with higher S100β protein levels at admission had poor recovery at 1 month compared to patients having normal S100β protein levels. Conclusion: S100β protein levels at admission after an acute MCA territory infarct may be used as a reliable serological tool in predicting the severity, outcome, and functional recovery in stroke.

Insulin-Like Growth Factor I Accelerates Functional Recovery from Achilles Tendon Injury in a Rat Model

1999 ◽  
Vol 27 (3) ◽  
pp. 363-369 ◽  
Author(s):  
Christopher A. Kurtz ◽  
Thomas G. Loebig ◽  
Donald D. Anderson ◽  
Patrick J. DeMeo ◽  
Phil G. Campbell
Keyword(s):  
Growth Factor ◽  
Achilles Tendon ◽  
Functional Recovery ◽  
Rat Model ◽  
Tendon Injury ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Impact of Post-Stroke Recanalization on General and Upper Limb Functioning: A Prospective, Observational Study

2021 ◽  
Vol 13 (1) ◽  
pp. 46-58
Author(s):  
João Paulo Branco ◽  
Filipa Rocha ◽  
João Sargento-Freitas ◽  
Gustavo C. Santo ◽  
António Freire ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Observational Study ◽  
Acute Ischemic Stroke ◽  
Upper Limb ◽  
Functional Recovery ◽  
Prospective Observational Study ◽  
Positive Impact ◽  
Rehabilitation Program ◽  
Patient Functioning ◽  
The Impact

The objective of this study is to assess the impact of recanalization (spontaneous and therapeutic) on upper limb functioning and general patient functioning after stroke. This is a prospective, observational study of patients hospitalized due to acute ischemic stroke in the territory of the middle cerebral artery (n = 98). Patients completed a comprehensive rehabilitation program and were followed-up for 24 weeks. The impact of recanalization on patient functioning was evaluated using the modified Rankin Scale (mRS) and Stroke Upper Limb Capacity Scale (SULCS). General and upper limb functioning improved markedly in the first three weeks after stroke. Age, gender, and National Institutes of Health Stroke Scale (NIHSS) score at admission were associated with general and upper limb functioning at 12 weeks. Successful recanalization was associated with better functioning. Among patients who underwent therapeutic recanalization, NIHSS scores ≥16.5 indicate lower general functioning at 12 weeks (sensibility = 72.4%; specificity = 78.6%) and NIHSS scores ≥13.5 indicate no hand functioning at 12 weeks (sensibility = 83.8%; specificity = 76.5%). Recanalization, either spontaneous or therapeutic, has a positive impact on patient functioning after acute ischemic stroke. Functional recovery occurs mostly within the first 12 weeks after stroke, with greater functional gains among patients with successful recanalization. Higher NIHSS scores at admission are associated with worse functional recovery.

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