scholarly journals RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro

2015 ◽  
Vol 93 (8) ◽  
pp. Spc1-Spc1
Author(s):  
Chiara Soldati ◽  
Pasquale Caramanica ◽  
Matthew J. Burney ◽  
Camilla Toselli ◽  
Angela Bithell ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Progenitor Cells ◽  
Subventricular Zone ◽  
Adult Mouse ◽  
Neural Stem Progenitor Cells

RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro

2015 ◽  
Vol 93 (8) ◽  
pp. 1203-1214 ◽  
Author(s):  
Chiara Soldati ◽  
Pasquale Caramanica ◽  
Matthew J. Burney ◽  
Camilla Toselli ◽  
Angela Bithell ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Progenitor Cells ◽  
Subventricular Zone ◽  
Adult Mouse ◽  
Neural Stem Progenitor Cells

scholarly journals Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor.

1995 ◽  
Vol 15 (6) ◽  
pp. 3147-3153 ◽  
Author(s):  
G A Blobel ◽  
C A Sieff ◽  
S H Orkin
Keyword(s):  
Bone Marrow ◽  
Estrogen Receptor ◽  
Transcription Factor ◽  
Progenitor Cells ◽  
Erythroid Cell ◽  
High Dose ◽  
Dependent Manner ◽  
Erythroid Progenitor ◽  
Erythroid Progenitor Cells

High-dose estrogen administration induces anemia in mammals. In chickens, estrogens stimulate outgrowth of bone marrow-derived erythroid progenitor cells and delay their maturation. This delay is associated with down-regulation of many erythroid cell-specific genes, including alpha- and beta-globin, band 3, band 4.1, and the erythroid cell-specific histone H5. We show here that estrogens also reduce the number of erythroid progenitor cells in primary human bone marrow cultures. To address potential mechanisms by which estrogens suppress erythropoiesis, we have examined their effects on GATA-1, an erythroid transcription factor that participates in the regulation of the majority of erythroid cell-specific genes and is necessary for full maturation of erythrocytes. We demonstrate that the transcriptional activity of GATA-1 is strongly repressed by the estrogen receptor (ER) in a ligand-dependent manner and that this repression is reversible in the presence of 4-hydroxytamoxifen. ER-mediated repression of GATA-1 activity occurs on an artificial promoter containing a single GATA-binding site, as well as in the context of an intact promoter which is normally regulated by GATA-1. GATA-1 and ER bind to each other in vitro in the absence of DNA. In coimmunoprecipitation experiments using transfected COS cells, GATA-1 and ER associate in a ligand-dependent manner. Mapping experiments indicate that GATA-1 and the ER form at least two contacts, which involve the finger region and the N-terminal activation domain of GATA-1. We speculate that estrogens exert effects on erythropoiesis by modulating GATA-1 activity through protein-protein interaction with the ER. Interference with GATA-binding proteins may be one mechanism by which steroid hormones modulate cellular differentiation.

Reactive astrogliosis induces astrocytic differentiation of adult neural stem/progenitor cells in vitro

2006 ◽  
Vol 84 (7) ◽  
pp. 1415-1424 ◽  
Author(s):  
J. Faijerson ◽  
R.B. Tinsley ◽  
K. Apricó ◽  
A. Thorsell ◽  
C. Nodin ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Reactive Astrogliosis ◽  
Astrocytic Differentiation ◽  
Neural Stem Progenitor Cells

Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination

1999 ◽  
Vol 11 (12) ◽  
pp. 4357-4366 ◽  
Author(s):  
Brahim Nait-Oumesmar ◽  
Laurence Decker ◽  
François Lachapelle ◽  
Virginia Avellana-Adalid ◽  
Corinne Bachelin ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Subventricular Zone ◽  
Adult Mouse

scholarly journals Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone

2020 ◽  
Vol 15 (10) ◽  
pp. 1773 ◽  
Author(s):  
Giuseppe Lupo ◽  
Giancarlo Poiana ◽  
Roberta Gioia ◽  
Serena Sineri ◽  
Silvia Cardarelli ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Progenitor Cells ◽  
Subventricular Zone ◽  
Neural Stem Progenitor Cells

scholarly journals proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro

2013 ◽  
Vol 11 (2) ◽  
pp. 874-887 ◽  
Author(s):  
Jingjing Guo ◽  
Jianing Wang ◽  
Chunrong Liang ◽  
Jun Yan ◽  
Yeran Wang ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Stem Progenitor Cells

Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1

Blood ◽  
2000 ◽  
Vol 95 (7) ◽  
pp. 2198-2203 ◽  
Author(s):  
Liquan Gao ◽  
Ilaria Bellantuono ◽  
Annika Elsässer ◽  
Stephen B. Marley ◽  
Myrtle Y. Gordon ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chronic Myeloid Leukemia ◽  
T Lymphocytes ◽  
Progenitor Cells ◽  
Cytotoxic T Lymphocytes ◽  
Colony Formation ◽  
Myeloid Leukemia ◽  
Leukemia Cell

Abstract Hematologic malignancies such as acute and chronic myeloid leukemia are characterized by the malignant transformation of immature CD34+ progenitor cells. Transformation is associated with elevated expression of the Wilm's tumor gene encoded transcription factor (WT1). Here we demonstrate that WT1 can serve as a target for cytotoxic T lymphocytes (CTL) with exquisite specificity for leukemic progenitor cells. HLA-A0201– restricted CTL specific for WT1 kill leukemia cell lines and inhibit colony formation by transformed CD34+ progenitor cells isolated from patients with chronic myeloid leukemia (CML), whereas colony formation by normal CD34+ progenitor cells is unaffected. Thus, the tissue-specific transcription factor WT1 is an ideal target for CTL-mediated purging of leukemic progenitor cells in vitro and for antigen-specific therapy of leukemia and other WT1-expressing malignancies in vivo.

Effects of elevated magnesium and substrate on neuronal numbers and neurite outgrowth of neural stem/progenitor cells in vitro

2014 ◽  
Vol 84 ◽  
pp. 72-78 ◽  
Author(s):  
John J. Vennemeyer ◽  
Tracy Hopkins ◽  
Julia Kuhlmann ◽  
William R. Heineman ◽  
Sarah K. Pixley
Keyword(s):  
Neurite Outgrowth ◽  
Progenitor Cells ◽  
Neural Stem Progenitor Cells
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