Antinociceptive roles of galanin receptor 1 in nucleus accumbens of rats in a model of neuropathic pain

2015 ◽  
Vol 93 (10) ◽  
pp. 1542-1551 ◽  
Author(s):  
Hao Duan ◽  
Ying Zhang ◽  
Xiao-Min Zhang ◽  
Huan-Huan Xu ◽  
Jun Shu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nucleus Accumbens ◽  
Galanin Receptor ◽  
Galanin Receptor 1

scholarly journals Galanin Receptor 1 Plays an Antinociceptive Effect via Inhibiting PKA Activation in the Nucleus Accumbens of Rats With Neuropathic Pain

2019 ◽  
pp. 511-518 ◽  
Author(s):  
Y. ZHANG ◽  
Y. GAO ◽  
C.-Y. LI ◽  
W. DONG ◽  
Y. DONG ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nucleus Accumbens ◽  
Sciatic Nerve ◽  
Antinociceptive Effect ◽  
Underlying Mechanism ◽  
Galanin Receptor ◽  
Nociceptive Information ◽  
The Central Nervous System ◽  
Galanin Receptors ◽  
Galanin Receptor 1

Galanin and galanin receptors (GalRs) have been reported to be involved in the transmission and modulation of nociceptive information in the central nervous system (CNS). However, the underlying mechanism of the antinociception of GalRs in neuropathic pain remains unclear. This study investigated the antinociception induced by galanin receptor 1 (GalR1) via protein kinase A (PKA) signaling pathway in the nucleus accumbens (NAc) of rats with neuropathic pain. A mononeuropathy model was replicated by ligation of the left sciatic nerve, following which the expression of phospho-PKA (p-PKA) in the NAc were markedly up-regulated at 14th and 28th day after ligation of sciatic nerve, and p-PKA expression was down-regulated by intra-NAc injection of GalR1 agonist M617, but the GalR1 antagonist M35 did not have an effect. We also found that M35 in the NAc blocked the M617-induced increase in the hind paw withdrawal latencies (HWLs) of rats with mononeuropathy, but M35 alone had no effect on HWLs, and PKA inhibitor H-89 attenuated the M617-induced an increase in the HWLs. These results suggested that GalR1 induced an antinociception via inhibiting PKA activation, implying that GalR agonists may be potential and potent therapeutic options to treat chronic neuropathic pain.

scholarly journals The activation of galanin receptor 2 plays an antinociceptive effect in nucleus accumbens of rats with neuropathic pain

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Yan Dong ◽  
Chong-Yang Li ◽  
Xiao-Min Zhang ◽  
Ya-Nan Liu ◽  
Shuang Yang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nucleus Accumbens ◽  
Pain Threshold ◽  
Antinociceptive Effect ◽  
Galanin Receptor ◽  
Pain Model ◽  
Withdrawal Threshold ◽  
Neuropathic Pain Model ◽  
Galanin Receptors ◽  
Intact Rats

AbstractOur previous research has shown that galanin plays an antinociceptive effect via binding to galanin receptors (GalRs) in nucleus accumbens (NAc). This study focused on the involvement of GalR2 in galanin-induced antinociceptive effect in NAc of neuropathic pain rats. The chronic constriction injury of sciatic nerve (CCI) was used to mimic neuropathic pain model. The hind paw withdrawal latency (HWL) to thermal stimulation and hind paw withdrawal threshold (HWT) to mechanical stimulation were measured as the indicators of pain threshold. The results showed that 14 and 28 days after CCI, the expression of GalR2 was up-regulated in bilateral NAc of rats, and intra-NAc injection of GalR2 antagonist M871 reversed galanin-induced increases in HWL and HWT of CCI rats. Furthermore, intra-NAc injection of GalR2 agonist M1145 induced increases in HWL and HWT at day 14 and day 28 after CCI, which could also be reversed by M871. Finally, we found that M1145-induced antinociceptive effect in NAc of CCI rats was stronger than that in intact rats. These results imply that the GalR2 is activated in the NAc from day 14 to day 28 after CCI and GalR2 is involved in the galanin-induced antinociceptive effect in NAc of CCI rats.

Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors

Neuroscience ◽  
2003 ◽  
Vol 117 (1) ◽  
pp. 221-227 ◽  
Author(s):  
K.H. Blakeman ◽  
J.-X. Hao ◽  
X.-J. Xu ◽  
A.S. Jacoby ◽  
J. Shine ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Galanin Receptor ◽  
Galanin Receptor 1

Antinociceptive effects induced by intra-lateral habenula complex injection of the galanin receptor 1 agonist M617 in rats

2015 ◽  
Vol 234 (2) ◽  
pp. 493-497
Author(s):  
Li-Bo Fu ◽  
Ying Wang ◽  
Xiao-Xiao Sun ◽  
Xiao-Xia Liu ◽  
Ying Wang ◽  
...  
Keyword(s):  
Galanin Receptor ◽  
Lateral Habenula ◽  
Antinociceptive Effects ◽  
Galanin Receptor 1

Identification of galanin receptor 1 on excitatory motor neurons in the guinea pig ileum

2005 ◽  
Vol 17 (2) ◽  
pp. 273-280 ◽  
Author(s):  
l. anselmi ◽  
e. cervio ◽  
s. guerrini ◽  
r. vicini ◽  
a. agazzi ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Motor Neurons ◽  
Guinea Pig Ileum ◽  
Galanin Receptor ◽  
Galanin Receptor 1

Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization

2010 ◽  
Vol 393 (4) ◽  
pp. 767-772 ◽  
Author(s):  
Dasiel O. Borroto-Escuela ◽  
Manuel Narvaez ◽  
Daniel Marcellino ◽  
Concepción Parrado ◽  
José Angel Narvaez ◽  
...  
Keyword(s):  
Galanin Receptor ◽  
Galanin Receptor 1

Activation of galanin receptor 1 inhibits locus coeruleus neurons via GIRK channels

2018 ◽  
Vol 503 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Yun-Fei Bai ◽  
Hai-Tao Ma ◽  
Li-Na Liu ◽  
Hui Li ◽  
Xiao-Xiao Li ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Galanin Receptor ◽  
Girk Channels ◽  
Galanin Receptor 1

Expression of galanin and galanin receptor-1 in normal bone and during fracture repair in the rat

Bone ◽  
2003 ◽  
Vol 33 (5) ◽  
pp. 788-797 ◽  
Author(s):  
Aaron C McDonald ◽  
John A Schuijers ◽  
Pei-Juan Shen ◽  
Andrew L Gundlach ◽  
Brian L Grills
Keyword(s):  
Fracture Repair ◽  
Galanin Receptor ◽  
Normal Bone ◽  
Galanin Receptor 1
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