Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss

2015 ◽  
Vol 93 (5) ◽  
pp. 788-795 ◽  
Author(s):  
Daisuke Yamashita ◽  
Guang-wei Sun ◽  
Yong Cui ◽  
Shiro Mita ◽  
Naoki Otsuki ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
Neuroprotective Effects ◽  
Sigma 1 Receptor ◽  
Sigma 1

Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity

Neuroreport ◽  
2005 ◽  
Vol 16 (11) ◽  
pp. 1223-1226 ◽  
Author(s):  
Agostino Marrazzo ◽  
Filippo Caraci ◽  
Elisa Trovato Salinaro ◽  
Tsung-Ping Su ◽  
Agata Copani ◽  
...  
Keyword(s):  
Beta Amyloid ◽  
Neuroprotective Effects ◽  
Sigma 1 Receptor ◽  
Receptor Agonists ◽  
Sigma 1

scholarly journals Neuroprotective effects of high affinity sigma 1 receptor selective compounds

2012 ◽  
Vol 1441 ◽  
pp. 17-26 ◽  
Author(s):  
Robert R. Luedtke ◽  
Evelyn Perez ◽  
Shao-Hua Yang ◽  
Ran Liu ◽  
Suwanna Vangveravong ◽  
...  
Keyword(s):  
Neuroprotective Effects ◽  
Sigma 1 Receptor ◽  
High Affinity ◽  
Sigma 1

Neuroprotective effects of T-817MA against noise-induced hearing loss

2008 ◽  
Vol 61 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Daisuke Yamashita ◽  
Akihiro Shiotani ◽  
Sho Kanzaki ◽  
Masaya Nakagawa ◽  
Kaoru Ogawa
Keyword(s):  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
Neuroprotective Effects

Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice

2012 ◽  
Vol 237 (2) ◽  
pp. 388-395 ◽  
Author(s):  
E. Griesmaier ◽  
A. Posod ◽  
M. Gross ◽  
V. Neubauer ◽  
K. Wegleiter ◽  
...  
Keyword(s):  
Brain Injury ◽  
Perinatal Brain Injury ◽  
Neuroprotective Effects ◽  
Receptor Ligand ◽  
Newborn Mice ◽  
Sigma 1 Receptor ◽  
Sigma 1

scholarly journals Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice

2021 ◽  
Vol 22 (13) ◽  
pp. 6956
Author(s):  
Núria Gaja-Capdevila ◽  
Neus Hernández ◽  
Daniel Zamanillo ◽  
Jose Miguel Vela ◽  
Manuel Merlos ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Palliative Surgery ◽  
Lumbar Spinal Cord ◽  
Spinal Root ◽  
Post Injury ◽  
Neuroprotective Effects ◽  
Sigma 1 Receptor ◽  
Adult Mice ◽  
Root Injury ◽  
Sigma 1

Loss of motor neurons (MNs) after spinal root injury is a drawback limiting the recovery after palliative surgery by nerve or muscle transfers. Research based on preventing MN death is a hallmark to improve the perspectives of recovery following severe nerve injuries. Sigma-1 receptor (Sig-1R) is a protein highly expressed in MNs, proposed as neuroprotective target for ameliorating MN degenerative conditions. Here, we used a model of L4–L5 rhizotomy in adult mice to induce MN degeneration and to evaluate the neuroprotective role of Sig-1R ligands (PRE-084, SA4503 and BD1063). Lumbar spinal cord was collected at 7, 14, 28 and 42 days post-injury (dpi) for immunohistochemistry, immunofluorescence and Western blot analyses. This proximal axotomy at the immediate postganglionic level resulted in significant death, up to 40% of spinal MNs at 42 days after injury and showed markedly increased glial reactivity. Sig-1R ligands PRE-084, SA4503 and BD1063 reduced MN loss by about 20%, associated to modulation of endoplasmic reticulum stress markers IRE1α and XBP1. These pathways are Sig-1R specific since they were not produced in Sig-1R knockout mice. These findings suggest that Sig-1R is a promising target for the treatment of MN cell death after neural injuries.

scholarly journals Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

Cells ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 211 ◽  
Author(s):  
Maximilian Christ ◽  
Heike Huesmann ◽  
Heike Nagel ◽  
Andreas Kern ◽  
Christian Behl
Keyword(s):  
Clinical Investigation ◽  
Receptor Activation ◽  
Autophagic Flux ◽  
Neuroprotective Effects ◽  
Sigma 1 Receptor ◽  
C Elegans ◽  
Protein Clearance ◽  
Sigma 1

Dysfunction of autophagy and disturbed protein homeostasis are linked to the pathogenesis of human neurodegenerative diseases and the modulation of autophagy as the protein clearance process has become one key pharmacological target. Due to the role of sigma-1 receptors (Sig-1R) in learning and memory, and the described pleiotropic neuroprotective effects in various experimental paradigms, Sig-1R activation is recognized as one potential approach for prevention and therapy of neurodegeneration and, interestingly, in amyotrophic lateral sclerosis associated with mutated Sig-1R, autophagy is disturbed. Here we analyzed the effects of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73), a muscarinic receptor ligand and Sig-1R agonist, on autophagy and proteostasis. We describe, at the molecular level, for the first time, that pharmacological Sig-1R activation a) enhances the autophagic flux in human cells and in Caenorhabditis elegans and b) increases proteostasis capacity, ultimately ameliorating paralysis caused by protein aggregation in C. elegans. ANAVEX2-73 is already in clinical investigation for the treatment of Alzheimer’s disease, and the novel activities of this compound on autophagy and proteostasis described here may have consequences for the use and further development of the Sig-1R as a drug target in the future. Moreover, our study defines the Sig-1R as an upstream modulator of canonical autophagy, which may have further implications for various conditions with dysfunctional autophagy, besides neurodegeneration.

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation

2014 ◽  
Vol 62 ◽  
pp. 218-232 ◽  
Author(s):  
Marco Peviani ◽  
Eleonora Salvaneschi ◽  
Leonardo Bontempi ◽  
Alessandro Petese ◽  
Antonio Manzo ◽  
...  
Keyword(s):  
Mouse Model ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Neuroprotective Effects ◽  
Sigma 1 Receptor ◽  
Sod1 Mutation ◽  
Sigma 1

Cleistocalyx nervosum var. paniala seed extracts exhibit sigma-1 antagonist sensitive neuroprotective effects in PC12 cells and protect C. elegans from stress via the SKN-1/NRF-2 pathway

2021 ◽  
pp. 1-16
Author(s):  
James Michael Brimson ◽  
Mani Iyer Prasanth ◽  
Ciro Isidoro ◽  
Monruedee Sukprasansap ◽  
Tewin Tencomnao
Keyword(s):  
Pc12 Cells ◽  
Amyloid Β ◽  
Wild Type ◽  
Health Food ◽  
Neuroprotective Effects ◽  
Sigma 1 Receptor ◽  
C Elegans ◽  
Aging Properties ◽  
Sigma 1 ◽  
Seed Extracts

BACKGROUND: Cleistocalyx nervosum var. paniala (C. nervosum) is a plant that produces berries that are popular as a health food in Thailand. In previous studies we have identified C. nervosum fruit extracts to have anti-aging and anti-stress properties in C.elegans OBJECTIVE: Evaluate the neuroprotective properties of C. nervosum seed extracts and investigate the mechanisms behind their neuroprotective properties. METHODS: PC-12 cells were differentiated using NGF and treated with amyloid-β (Aβ)  (25–35)  creating a model of neurodegeneration, in which C. nervosum seed extracts were tested for neuroprotective properties. Cell viability was measured after 24 hours of using the MTT assay. We also measured the lifespan and “health span” of various C.elegans mutants and the wild type. RESULTS: C. nervosum seed extract protects PC12 cells from Aβ  (25–35)  toxicity, as well as potentiating NGF induced neurite outgrowth in the same cell line potentially under the control of the sigma-1 receptor. C. nervosum seed extracts have anti-aging properties in C. elegans, causing a significant increase in lifespan of Aβ expressing C. elegans and wild type worms. This appears to be regulated by SKN-1/NRF-2, possibly via the sigma-1 receptor. The DAF-16 pathway is also involved in the lifespan extension of C. elegans. CONCLUSIONS: C. nervousum has been often used as a functional food. We have shown its neuroprotective properties which are sensitive to sigma-1 receptor antagonism in PC12 cells, and involve the SKN-1/NRF-2 and DAF-16 pathway in C.elegans. Further research into the active compounds may lead to future drugs for preventing or treating neurodegenerative disease.

For Those About to Rock

2012 ◽  
Vol 13 (1) ◽  
pp. 29-35
Author(s):  
Jennifer Tufts
Keyword(s):  
Hearing Loss ◽  
Cultural Landscape ◽  
Minimal Risk ◽  
Noise Induced Hearing Loss ◽  
Essential Information ◽  
Informed Decisions ◽  
Hearing Health ◽  
Loud Music ◽  
Protective Strategies

Loud music and noisy hobbies are part of our cultural landscape. These activities can be enjoyed with minimal risk to hearing if a few commonsense guidelines are followed. Educating clients about risks and protective strategies will empower them to make informed decisions about their hearing health that best reflect their values and priorities. In this article, the author covers essential information to avoiding noise-induced hearing loss, writing in easily accessible language to better help clinicians convey this information to their clients.

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