Palmitic acid affects proliferation and differentiation of neural stem cells in vitro

2014 ◽  
Vol 92 (5) ◽  
pp. 574-586 ◽  
Author(s):  
Zhen Wang ◽  
Dexiang Liu ◽  
Qun Zhang ◽  
Jianmei Wang ◽  
Jingmin Zhan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Palmitic Acid ◽  
Proliferation And Differentiation

Combined use of NGF/BDNF/bFGF promotes proliferation and differentiation of neural stem cells in vitro

2014 ◽  
Vol 38 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Shuang‐Qing Chen ◽  
Qing Cai ◽  
Yu‐Ying Shen ◽  
Xiu‐Ying Cai ◽  
Hai‐Ying Lei
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Combined Use ◽  
Proliferation And Differentiation

scholarly journals Effects of Oxygen Concentration on the Proliferation and Differentiation of Mouse Neural Stem Cells In Vitro

2008 ◽  
Vol 28 (6) ◽  
pp. 833-845 ◽  
Author(s):  
Nobutaka Horie ◽  
Kenji So ◽  
Takahiro Moriya ◽  
Naoki Kitagawa ◽  
Keisuke Tsutsumi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Oxygen Concentration ◽  
Proliferation And Differentiation

Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice

2019 ◽  
Vol 29 (5) ◽  
pp. 727-735 ◽  
Author(s):  
Yuhang Cao ◽  
Yingliang Zhuang ◽  
Junchen Chen ◽  
Weize Xu ◽  
Yikai Shou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neuronal Development ◽  
Conditional Knockout ◽  
Biological Processes ◽  
Adult Neural Stem Cells ◽  
Proliferation And Differentiation

Abstract N 6-methyladenosine (m6A) modification of RNA is deposited by the methyltransferase complex consisting of Mettl3 and Mettl14 and erased by demethylase Fto and Alkbh5 and is involved in diverse biological processes. However, it remains largely unknown the specific function and mechanism of Fto in regulating adult neural stem cells (aNSCs). In the present study, utilizing a conditional knockout (cKO) mouse model, we show that the specific ablation of Fto in aNSCs transiently increases the proliferation of aNSCs and promotes neuronal differentiation both in vitro and in vivo, but in a long term, the specific ablation of Fto inhibits adult neurogenesis and neuronal development. Mechanistically, Fto deficiency results in a significant increase in m6A modification in Pdgfra and Socs5. The increased expression of Pdgfra and decreased expression of Socs5 synergistically promote the phosphorylation of Stat3. The modulation of Pdgfra and Socs5 can rescue the neurogenic deficits induced by Fto depletion. Our results together reveal an important function of Fto in regulating aNSCs through modulating Pdgfra/Socs5-Stat3 pathway.

Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro

2011 ◽  
Vol 51 (1) ◽  
pp. 104-112 ◽  
Author(s):  
Jie Fu ◽  
Shi-Dou Zhao ◽  
Hui-Juan Liu ◽  
Qiu-Huan Yuan ◽  
Shang-Ming Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Proliferation And Differentiation

Manipulation of proliferation and differentiation of human bone marrow-derived neural stem cells in vitro and in vivo

2007 ◽  
Vol 85 (2) ◽  
pp. 310-320 ◽  
Author(s):  
Zhaohui Zeng ◽  
Xiangpeng Yuan ◽  
Gentao Liu ◽  
Xianhao Zeng ◽  
Xiaorong Zeng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Neural Stem Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Proliferation And Differentiation
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