Selective activation of group III metabotropic glutamate receptor subtypes produces different patterns of γ-aminobutyric acid immunoreactivity and glutamate release in the retina

2012 ◽  
Vol 90 (12) ◽  
pp. 2349-2361 ◽  
Author(s):  
E.M. Guimarães-Souza ◽  
K.C. Calaza
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Glutamate Release ◽  
Aminobutyric Acid ◽  
Receptor Subtypes ◽  
Selective Activation ◽  
Group Iii ◽  
Metabotropic Glutamate

scholarly journals Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor

Biomolecules ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 234 ◽  
Author(s):  
Kouji Fukuyama ◽  
Ryo Kato ◽  
Masahiko Murata ◽  
Takashi Shiroyama ◽  
Motohiro Okada
Keyword(s):  
Glutamate Receptor ◽  
Thalamic Nucleus ◽  
Metabotropic Glutamate Receptor ◽  
Glutamate Release ◽  
Local Administration ◽  
Group Iii ◽  
Metabotropic Glutamate ◽  
Cultured Astrocytes ◽  
Nmda Glutamate Receptors ◽  
Toxic Concentrations

Pharmacological mechanisms of gold-standard antipsychotics against treatment-refractory schizophrenia, such as clozapine (CLZ), remain unclear. We aimed to explore the mechanisms of CLZ by investigating the effects of MK801 and CLZ on tripartite synaptic transmission in the thalamocortical glutamatergic pathway using multi-probe microdialysis and primary cultured astrocytes. l-glutamate release in the medial prefrontal cortex (mPFC) was unaffected by local MK801 administration into mPFC but was enhanced in the mediodorsal thalamic nucleus (MDTN) and reticular thalamic nucleus (RTN) via GABAergic disinhibition in the RTN–MDTN pathway. The local administration of therapeutically relevant concentrations of CLZ into mPFC and MDTN increased and did not affect mPFC l-glutamate release. The local administration of the therapeutically relevant concentration of CLZ into mPFC reduced MK801-induced mPFC l-glutamate release via presynaptic group III metabotropic glutamate receptor (III-mGluR) activation. However, toxic concentrations of CLZ activated l-glutamate release associated with hemichannels. This study demonstrated that RTN is a candidate generator region in which impaired N-methyl-d-aspartate (NMDA)/glutamate receptors likely produce thalamocortical hyperglutamatergic transmission. Additionally, we identified several mechanisms of CLZ relating to its superiority in treatment-resistant schizophrenia and its severe adverse effects: (1) the prevention of thalamocortical hyperglutamatergic transmission via activation of mPFC presynaptic III-mGluR and (2) activation of astroglial l-glutamate release associated with hemichannels. These actions may contribute to the unique clinical profile of CLZ.

scholarly journals The C Terminus of the Metabotropic Glutamate Receptor Subtypes 2 and 7 Specifies the Receptor Signaling Pathways

2001 ◽  
Vol 276 (49) ◽  
pp. 45800-45805 ◽  
Author(s):  
Julie Perroy ◽  
Gustavo J. Gutierrez ◽  
Vincent Coulon ◽  
Joel Bockaert ◽  
Jean-Pilippe Pin ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Subtypes ◽  
Receptor Signaling ◽  
Metabotropic Glutamate ◽  
C Terminus

scholarly journals Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

1997 ◽  
Vol 17 (19) ◽  
pp. 7503-7522 ◽  
Author(s):  
Ryuichi Shigemoto ◽  
Ayae Kinoshita ◽  
Eiki Wada ◽  
Sakashi Nomura ◽  
Hitoshi Ohishi ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Rat Hippocampus ◽  
Receptor Subtypes ◽  
Metabotropic Glutamate

scholarly journals Agonist analysis of 2-(carboxy-cyclopropyl)glycines (CCGs) for cloned metabotropic glutamate receptor subtypes.

1993 ◽  
Vol 61 ◽  
pp. 244
Author(s):  
Yasunori Hayashi ◽  
Yasuto Tanabe ◽  
Ichiro Aramori ◽  
Masayuki Masuyuki ◽  
Shigetada Nakanishi
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Subtypes ◽  
Metabotropic Glutamate
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