Transgenic mice expressing yellow fluorescent protein under control of the human tyrosine hydroxylase promoter

2012 ◽  
Vol 90 (10) ◽  
pp. 1949-1959 ◽  
Author(s):  
Eun Yang Choi ◽  
Jae Won Yang ◽  
Myung Sun Park ◽  
Woong Sun ◽  
Hyun Kim ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Transgenic Mice ◽  
Fluorescent Protein ◽  
Yellow Fluorescent Protein ◽  
Tyrosine Hydroxylase Promoter

Analysis of the human tyrosine hydroxylase promoter-chloramphenicol acetyltransferase chimeric gene expression in transgenic mice

1992 ◽  
Vol 16 (3-4) ◽  
pp. 274-286 ◽  
Author(s):  
Toshikuni Sasaoka ◽  
Kazuto Kobayashi ◽  
Ikuko Nagatsu ◽  
Riichi Takahashi ◽  
Minoru Kimura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tyrosine Hydroxylase ◽  
Transgenic Mice ◽  
Chloramphenicol Acetyltransferase ◽  
Chimeric Gene ◽  
Tyrosine Hydroxylase Promoter

scholarly journals Regulation of Tyrosine Hydroxylase Promoter Activity by Chronic Morphine in TH9.0-LacZ Transgenic Mice

1998 ◽  
Vol 18 (23) ◽  
pp. 9989-9995 ◽  
Author(s):  
Virginia A. Boundy ◽  
Stephen J. Gold ◽  
Chad J. Messer ◽  
Jingshan Chen ◽  
Jin H. Son ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Transgenic Mice ◽  
Promoter Activity ◽  
Chronic Morphine ◽  
Tyrosine Hydroxylase Promoter

Lack of Nigral Pathology in Transgenic Mice Expressing Human α-Synuclein Driven by the Tyrosine Hydroxylase Promoter

2001 ◽  
Vol 8 (3) ◽  
pp. 535-539 ◽  
Author(s):  
Yasuji Matsuoka ◽  
Miquel Vila ◽  
Sarah Lincoln ◽  
Alison McCormack ◽  
Melanie Picciano ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Transgenic Mice ◽  
Tyrosine Hydroxylase Promoter

scholarly journals GFP transgenic animals in biomedical research: a review of potential disadvantages

2019 ◽  
pp. 525-530
Author(s):  
N. Lipták ◽  
Z. Bősze ◽  
L. Hiripi
Keyword(s):  
Transgenic Mice ◽  
Biomedical Research ◽  
Fluorescent Protein ◽  
Yellow Fluorescent Protein ◽  
Transgenic Animals ◽  
In Vivo Studies ◽  
Reporter Protein ◽  
Physiological Processes ◽  
Green Fluorescent

Green Fluorescent protein (GFP) transgenic animals are accepted tools for studying various physiological processes, including organ development and cell migration. However, several in vivo studies claimed that GFP may impair transgenic animals’ health. Glomerulosclerosis was observed in transgenic mice and rabbits with ubiquitous reporter protein expression. Heart-specific GFP expression evoked dilated cardiomyopathy and altered cardiac function in transgenic mouse and zebrafish lines, respectively. Moreover, growth retardation and increased axon swelling were observed in GFP and yellow fluorescent protein (YFP) transgenic mice, respectively. This review will focus on the potential drawbacks of the applications of GFP transgenic animals in biomedical research.

scholarly journals Transgenic mice expressing luciferase under a 4.5 kb tyrosine hydroxylase promoter

Cureus ◽  
2011 ◽  
Author(s):  
Kenneth W. Dodd ◽  
Terry C. Burns ◽  
Stephen M. Weisner ◽  
Elina Kudishevich ◽  
Dominic T. Schomberg ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Transgenic Mice ◽  
Tyrosine Hydroxylase Promoter

Transgenic mice expressing a pH and Cl-sensing yellow-fluorescent protein under the control of a potassium channel promoter

2002 ◽  
Vol 15 (1) ◽  
pp. 40-50 ◽  
Author(s):  
Friedrich Metzger ◽  
Vez Repunte-Canonigo ◽  
Shinichi Matsushita ◽  
Walther Akemann ◽  
Javier Diez-Garcia ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Potassium Channel ◽  
Fluorescent Protein ◽  
Yellow Fluorescent Protein

scholarly journals Induction of Cell Stress in Neurons from Transgenic Mice Expressing Yellow Fluorescent Protein: Implications for Neurodegeneration Research

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17639 ◽  
Author(s):  
Laura H. Comley ◽  
Thomas M. Wishart ◽  
Becki Baxter ◽  
Lyndsay M. Murray ◽  
Ailish Nimmo ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Fluorescent Protein ◽  
Yellow Fluorescent Protein ◽  
Cell Stress

Thick ascending limb-specific expression of Cre recombinase

2003 ◽  
Vol 285 (1) ◽  
pp. F33-F39 ◽  
Author(s):  
Peter K. Stricklett ◽  
Deborah Taylor ◽  
Raoul D. Nelson ◽  
Donald E. Kohan
Keyword(s):  
Transgenic Mice ◽  
Fluorescent Protein ◽  
Genomic Library ◽  
Yellow Fluorescent Protein ◽  
Cre Recombinase ◽  
Specific Gene ◽  
Thick Ascending Limb ◽  
Specific Expression ◽  
Enhanced Yellow Fluorescent Protein

Evaluation of thick ascending limb (TAL) function has been hindered by the limited ability to selectively examine the function of this nephron segment in vivo. To address this, a Cre/loxP strategy was employed whereby the Tamm-Horsfall (THP) promoter was used to drive Cre recombinase expression in transgenic mice. The THP gene was cloned from a mouse genomic library, and 3.7 kb of the mouse THP 5′-flanking region containing the first noncoding exon of the THP gene were inserted upstream of an epitope-tagged Cre recombinase (THP-CreTag). THP-CreTag transgenic mice were bred with ROSA26-enhanced yellow fluorescent protein (eYFP) mice (contain a loxP-flanked “STOP” sequence 5′ to eYFP), and doubly heterozygous offspring were analyzed. THP and eYFP were expressed in an identical pattern with predominant localization to the renal outer medulla without expression in nonrenal tissues. eYFP did not colocalize with thiazide-sensitive cotransporter (distal tubule) or neuronal nitric oxide synthase (macula densa) expression. THP mRNA expression was detected only in kidney, whereas CreTag mRNA was also present in testes. These data indicate that THP-CreTag transgenic mice can be used for TAL-specific gene recombination in the kidney.

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