scholarly journals Persistence of psychosine in brain lipid rafts is a limiting factor in the therapeutic recovery of a mouse model for Krabbe disease

2010 ◽  
Vol 89 (3) ◽  
pp. 352-364 ◽  
Author(s):  
A.B. White ◽  
F. Galbiati ◽  
M.I. Givogri ◽  
A. Lopez Rosas ◽  
X. Qiu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Lipid Rafts ◽  
Krabbe Disease ◽  
Limiting Factor ◽  
Brain Lipid

scholarly journals Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice

2022 ◽  
Vol 8 (1) ◽  
Author(s):  
Ni An ◽  
Zhenjie Li ◽  
Xiaodi Yan ◽  
Hainan Zhao ◽  
Yajie Yang ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Lung Injury ◽  
Mouse Model ◽  
Tumor Cells ◽  
Nuclear Translocation ◽  
Lung Tumor ◽  
Lung Epithelial Cells ◽  
Normal Lung ◽  
Limiting Factor ◽  
Radiation Induced

AbstractThe lung is one of the most sensitive tissues to ionizing radiation, thus, radiation-induced lung injury (RILI) stays a key dose-limiting factor of thoracic radiotherapy. However, there is still little progress in the effective treatment of RILI. Ras-related C3 botulinum toxin substrate1, Rac1, is a small guanosine triphosphatases involved in oxidative stress and apoptosis. Thus, Rac1 may be an important molecule that mediates radiation damage, inhibition of which may produce a protective effect on RILI. By establishing a mouse model of radiation-induced lung injury and orthotopic lung tumor-bearing mouse model, we detected the role of Rac1 inhibition in the protection of RILI and suppression of lung tumor. The results showed that ionizing radiation induces the nuclear translocation of Rac1, the latter then promotes nuclear translocation of P53 and prolongs the residence time of p53 in the nucleus, thereby promoting the transcription of Trp53inp1 which mediates p53-dependent apoptosis. Inhibition of Rac1 significantly reduce the apoptosis of normal lung epithelial cells, thereby effectively alleviating RILI. On the other hand, inhibition of Rac1 could also significantly inhibit the growth of lung tumor, increase the radiation sensitivity of tumor cells. These differential effects of Rac1 inhibition were related to the mutation and overexpression of Rac1 in tumor cells.

18. Axonopathy in a mouse model of Krabbe disease

2010 ◽  
Vol 99 (2) ◽  
pp. S11-S12
Author(s):  
Ernesto Bongarzone ◽  
Ludovico Cantuti ◽  
Maria I. Givogri ◽  
Aurora Lopez-Rosas ◽  
Gustavo Pigino ◽  
...  
Keyword(s):  
Mouse Model ◽  
Krabbe Disease

scholarly journals Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Valentina Cappello ◽  
Laura Marchetti ◽  
Paola Parlanti ◽  
Silvia Landi ◽  
Ilaria Tonazzini ◽  
...  
Keyword(s):  
Mouse Model ◽  
Motor System ◽  
Krabbe Disease ◽  
Ultrastructural Characterization

Use of AAVrh10-GALC to Treat the Twitcher Mouse Model of Krabbe Disease

2012 ◽  
Vol 105 (2) ◽  
pp. S64
Author(s):  
David Wenger ◽  
Mohammad Rafi ◽  
Paola Luzi ◽  
Han Zhi Rao
Keyword(s):  
Mouse Model ◽  
Krabbe Disease ◽  
Twitcher Mouse

Amyloid β oligomerization is induced by brain lipid rafts

2006 ◽  
Vol 99 (3) ◽  
pp. 878-889 ◽  
Author(s):  
Sang-Il Kim ◽  
Jae-Sung Yi ◽  
Young-Gyu Ko
Keyword(s):  
Lipid Rafts ◽  
Amyloid Β ◽  
Brain Lipid

scholarly journals Reduction in miR‐219 expression underlies cellular pathogenesis of oligodendrocytes in a mouse model of Krabbe disease

2021 ◽  
Author(s):  
Naoko Inamura ◽  
Shinji Go ◽  
Takashi Watanabe ◽  
Hiroshi Takase ◽  
Nobuyuki Takakura ◽  
...  
Keyword(s):  
Mouse Model ◽  
Krabbe Disease ◽  
Cellular Pathogenesis

scholarly journals Lipid Rafts Control P2X3 Receptor Distribution and Function in Trigeminal Sensory Neurons of a Transgenic Migraine Mouse Model

2011 ◽  
Vol 7 ◽  
pp. 1744-8069-7-77 ◽  
Author(s):  
Aswini Gnanasekaran ◽  
Mayya Sundukova ◽  
Arn MJM van den Maagdenberg ◽  
Elsa Fabbretti ◽  
Andrea Nistri
Keyword(s):  
Mouse Model ◽  
Lipid Rafts ◽  
Sensory Neurons ◽  
P2x3 Receptor ◽  
And Function ◽  
Receptor Distribution
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