scholarly journals The wheat germ agglutinin-fractionated proteome of subjects with Alzheimer's disease and mild cognitive impairment hippocampus and inferior parietal lobule: Implications for disease pathogenesis and progression

2010 ◽  
Vol 88 (16) ◽  
pp. 3566-3577 ◽  
Author(s):  
Fabio Di Domenico ◽  
Joshua B. Owen ◽  
Rukhsana Sultana ◽  
Rena A. Sowell ◽  
Marzia Perluigi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Wheat Germ Agglutinin ◽  
Wheat Germ ◽  
Inferior Parietal Lobule ◽  
Disease Pathogenesis ◽  
Parietal Lobule

Increase of EEG Alpha3/Alpha2 Power Ratio Detects Inferior Parietal Lobule Atrophy in Mild Cognitive Impairment

2018 ◽  
Vol 15 (5) ◽  
pp. 443-451
Author(s):  
Davide V. Moretti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Clinical Feature ◽  
Power Ratio ◽  
Inferior Parietal Lobule ◽  
Mri Scans ◽  
Parietal Lobule ◽  
Early Alzheimer’S Disease

Objective: The inferior parietal lobule (IPL) has been implicate in many higher cognitive processes, as visuo-motor transformations, tool use or tool making. In subjects with mild cognitive impairment (MCI) at major risk to develop Alzheimer' Disease (AD) an impairment of subtle visuomotor or praxic abilities is a well-known clinical feature. Enhance of the ratio of EEG alpha3/alpha2 frequency power was detected in subjects with MCI who will transform in Alzheimer's disease (AD). Methods: We explored of the association of alpha3/alpha2 power ratio with cortical size of IPL in patients with MCI. 74 subjects with MCI undergone EEG recording and MRI scans. Alpha3/alpha2 power ratio in addition to cortical size had been computed for each patient. Three MCI groups had been acquired in keeping with growing tertile values of alpha3/alpha2 ratio. Huge difference of cortical thickness among the groups was calculated. Higher alpha3/alpha2 power ratio group had broader cortical loss compared to other teams on the IPL, particularly in the Supramarginal Gyrus, and Precuneus on both hemispheres. Results: Our results unveil the possible part that the IPL could play in determining the classic alterations of early Alzheimer's disease (AD). Conclusion: Finally, the rise of alpha3/alpha2 power ratio detected a focused anatomo-functional association that could be a reliable marker of incipient AD.

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