Effects of zona incerta lesions on striatal neurochemistry and behavioral asymmetry in 6-hydroxydopamine-lesioned rats

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Ruth H. Walker ◽  
Georgia Davies ◽  
Rick J. Koch ◽  
Andrew K. Haack ◽  
Cynthia Moore ◽  
...  
Keyword(s):  
Zona Incerta ◽  
6 Hydroxydopamine ◽  
Behavioral Asymmetry

Oral motor deficits following lesions of the central nervous system in the rat

1979 ◽  
Vol 237 (3) ◽  
pp. R126-R131 ◽  
Author(s):  
C. C. Brimley ◽  
G. J. Mogenson
Keyword(s):  
Central Nervous System ◽  
Amygdaloid Complex ◽  
Dopamine Neurons ◽  
Zona Incerta ◽  
Motor Deficits ◽  
Oral Motor ◽  
The Central Nervous System ◽  
Far Lateral ◽  
6 Hydroxydopamine ◽  
Reduced Water

The effects of lesions of the zona incerta (ZI), globus pallidus (GP), midlateral and far lateral hypothalamus (MLH and FLH), and the central amygdaloid complex (CAC) on oral motor deficits were investigated. Lesions of the ZI, GP, and CAC resulted in a significant reduction in tongue extension and lap volume. MLH lesions significantly reduced tongue extension whereas FLH lesions significantly reduced both tongue extension and lap volume. Injections of 6-hydroxydopamine into the GP, MLH, and CAC also significantly reduced tongue extension and lap volume. Water and/or food intakes were reduced in some of the lesioned groups but the oral motor deficits were observed both in the presence and in the absence of reduced water and food intakes. The possibility that oral motor deficits are associated with damage to striatal and non-striatal dopamine neurons needs further investigation.

Effect of 6-Hydroxydopamine on Neonate Spontaneously Hypertensive and Normotensive Rats

1976 ◽  
Vol 17 (3) ◽  
pp. 419-419 ◽  
Author(s):  
Masayori OZAKI ◽  
Kazunobu SUGAWARA ◽  
Naoko TAKAMI ◽  
Masashi OGAWA ◽  
Masami NIWA
Keyword(s):  
Spontaneously Hypertensive ◽  
6 Hydroxydopamine

Bibliometrics and Visualization of the Mechanisms of Parkinson's Diseases Based on Animal Models

2020 ◽  
Vol 20 (10) ◽  
pp. 1560-1568 ◽  
Author(s):  
Yan-Qiu Wang ◽  
Yi-Bing Chen ◽  
Dong Xu ◽  
Yuan-Lu Cui
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Mitochondrial Protein ◽  
Bibliometric Method ◽  
Metabolism Disorder ◽  
Parkinson’S Diseases ◽  
Model Drug ◽  
6 Hydroxydopamine ◽  
Rats And Mice ◽  
Energy Metabolism Disorder

Objective: Energy metabolism disorder is one of the causes of Parkinson's disease (PD). Rodents, such as rats and mice are often used to establish animal models of PD. This paper used a bibliometric method to analyze the studies of rat and mouse PD models published between 2009 and 2018 in the Web of Science (WOS) database using CiteSpace V software. In addition, we conducted a literature review on the development status and research hotspots in this field in the past ten years. Methods: The related articles on rat and mouse PD models were retrieved from the WOS database, and an analysis of the keywords in these articles was conducted using CiteSpace V. A timeline graph was developed by the software in order to show the focus of researchers in the PD field. Results : A total of 8,636 articles were obtained. Results of the cluster analysis in the PD field such as neuroinflammation, oxidative stress, and autophagy, contributed to the systematic review about the pathogenesis of PD. At the same time, based on the property of the model drug, this review has summarized and compared different administration techniques and mechanisms of 6-hydroxydopamine (6- OHDA), 1-methyl-4-phenyl-1, 2, 4, 5-tetrahydropyridine (MPTP), paraquat and rotenone. Conclusion: According to the bibliometric analysis, studies on PD were focused on the mechanisms of oxidative stress, neuroinflammation, and autophagy. Activated microglia releases inflammatory cytokines; mitochondrial dysfunction is caused by oxidative damage of mitochondrial protein; abnormal autophagy-lysosome pathway can lead to abnormal protein deposition in dopaminergic neurons. In addition, although many animal models of PD have been established, there are some limitations of such models. Therefore, it is necessary to develop models that accurately mimic human PD.

scholarly journals Thalamic Input to Orbitofrontal Cortex Drives Brain-wide, Frequency-Dependent Inhibition Mediated by GABA and Zona Incerta

Neuron ◽  
2019 ◽  
Vol 104 (6) ◽  
pp. 1153-1167.e4 ◽  
Author(s):  
Andrew J. Weitz ◽  
Hyun Joo Lee ◽  
ManKin Choy ◽  
Jin Hyung Lee
Keyword(s):  
Orbitofrontal Cortex ◽  
Zona Incerta ◽  
Frequency Dependent ◽  
Thalamic Input ◽  
Dependent Inhibition

Behavior and oxidative stress parameters in rats subjected to the animal's models induced by chronic mild stress and 6-hydroxydopamine

2021 ◽  
Vol 406 ◽  
pp. 113226
Author(s):  
Talita Tuon ◽  
Sandra S. Meirelles ◽  
Airam B. de Moura ◽  
Thayse Rosa ◽  
Laura A. Borba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Oxidative Stress Parameters ◽  
6 Hydroxydopamine ◽  
And Oxidative Stress ◽  
Stress Parameters
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