Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats

2009 ◽  
Vol 87 (16) ◽  
pp. 3687-3696 ◽  
Author(s):  
Jose A. Morales-Garcia ◽  
Rosario Luna-Medina ◽  
Ana Martinez ◽  
Angel Santos ◽  
Ana Perez-Castillo
Keyword(s):  
Calcium Antagonist ◽  
Kainic Acid ◽  
The Novel ◽  
Neuroprotective Effects

Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats

2005 ◽  
Vol 1057 (1-2) ◽  
pp. 168-176 ◽  
Author(s):  
Yutaka Kitano ◽  
Chika Komiyama ◽  
Mitsuhiro Makino ◽  
Kiyoshi Takasuna ◽  
Hiroshi Satoh ◽  
...  
Keyword(s):  
Kainic Acid ◽  
The Novel ◽  
Neuroprotective Effects ◽  
Nootropic Agent

Hemodynamic and humoral effects of the novel calcium antagonist Ro 40-5967 in patients with hypertension

1992 ◽  
Vol 52 (3) ◽  
pp. 314-323 ◽  
Author(s):  
Rita Schmitt ◽  
Cornells H Kleinbloesem ◽  
Gustav G Belz ◽  
Volkmar Schroeter ◽  
Ulrich Feifel ◽  
...  
Keyword(s):  
Calcium Antagonist ◽  
The Novel

scholarly journals Xenon Exerts Neuroprotective Effects on Kainic Acid-Induced Acute Generalized Seizures in Rats via Increased Autophagy

2020 ◽  
Vol 14 ◽  
Author(s):  
Wei Zhu ◽  
Jianguo Zhu ◽  
Shengfa Zhao ◽  
Jieqing Li ◽  
Dianjun Hou ◽  
...  
Keyword(s):  
Kainic Acid ◽  
Neuroprotective Effects ◽  
Generalized Seizures

Neuroprotective effects of the novel polyethylene glycol-hemoglobin conjugate SB1 on experimental cerebral thromboembolism in rats

2007 ◽  
Vol 566 (1-3) ◽  
pp. 83-87 ◽  
Author(s):  
Hyeong-Jin Ji ◽  
Hee-Youl Chai ◽  
Sang-Soep Nahm ◽  
Junhee Lee ◽  
Gun Won Bae ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
The Novel ◽  
Neuroprotective Effects

scholarly journals Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Ziying Wang ◽  
Zhuanli Zhou ◽  
Xinbing Wei ◽  
Mingwei Wang ◽  
Bi-Ou Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Responses ◽  
Ischemia Reperfusion Injury ◽  
Therapeutic Potential ◽  
Ischemia Reperfusion ◽  
The Novel ◽  
Neuroprotective Effects ◽  
Chemical Structures ◽  
Cerebral Ischemia Reperfusion Injury ◽  
Blood Brain Barrier Integrity

Although studies have seen dramatic advances in the understanding of the pathogenesis of stroke such as oxidative stress, inflammation, excitotoxicity, calcium overload and apoptosis, the delivery of stroke therapies is still a great challenge. In this study, we designed and synthesized a series of novel twin compounds containing tetramethylpyrazine and carnitine substructures and explored their therapeutic potential and mechanism in stroke-related neuronal injury. We first screened the neuroprotective effects of candidate compounds and found that among the tested compounds, LR134 and LR143 exhibited significant neuroprotection as evidenced by reducing cerebral infarct and edema, improving neurological function as well as blood-brain barrier integrity in rats after cerebral ischemia/reperfusion injury. We further demonstrated that the neuroprotective effects of compounds LR134 and LR143 were associated with the reduced inflammatory responses and NADPH oxidase- (NOX2-) mediated oxidative stress and the protection of mitochondria accompanied by the improvement of energy supply. In summary, this study provides direct evidence showing that the novel twin compounds containing tetramethylpyrazine and carnitine substructures have neuroprotective effects with multiple therapeutic targets, suggesting that modulation of these chemical structures may be an innovative therapeutic strategy for treating patients with stroke.

Neuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms

2017 ◽  
Author(s):  
Luisa de Lemos ◽  
Felix Junyent ◽  
Antoni Camins ◽  
Rubén Darío Castro-Torres ◽  
Jaume Folch ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Kainic Acid ◽  
Temporal Lobe ◽  
Neuroprotective Effects

scholarly journals Neuroprotective Effects of Ganoderma curtisii Polysaccharides After Kainic Acid-Seizure Induced

2019 ◽  
Vol 11 (5) ◽  
pp. 1046-1054
Author(s):  
Ismael Leon-Rivera ◽  
Juana Villeda-Hernandez ◽  
Elizur Montiel-Arcos ◽  
Isaac Tello ◽  
Maria Yolanda Rios ◽  
...  
Keyword(s):  
Kainic Acid ◽  
Neuroprotective Effects

Efficacy of the Novel Calcium Antagonist R(+)-Semotiadil in Limiting the Ventricular Rate During Atrial Flutter in Isolated Guinea Pig Hearts

2000 ◽  
Vol 35 (2) ◽  
pp. 309-314 ◽  
Author(s):  
Ingrid Schwarzl ◽  
Ulrike Stark ◽  
Marianne Brodmann ◽  
Ulrike Haiden ◽  
Helmut A. Tritthart ◽  
...  
Keyword(s):  
Calcium Antagonist ◽  
Guinea Pig ◽  
Atrial Flutter ◽  
Ventricular Rate ◽  
The Novel
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